Abstract
The potential of 4-thiazolidones (2,4-thiazolidinediones, 2-thioxo(imino)-4-thiazolidones) as drugs is under consideration by the pharmaceutical science since the beginning of the XX century. During recent years a new phase has been seen in this field. Centerarian history of synthetic research possibilities of these heterocycles lead to diversity in modelling biologically active compounds using 4-thiazolidone scaffolds. Modification of the 4- thiazolidone cycle on 2-, 3-, 4- or 5-position is successful to achieve synthetic products with a wide spectrum of pharmacological activity and has received considerable attention in this review. Currently 4-thiazolidones are considered as a new class of antidiabetic (insulin-sensitising) drugs and potent aldose reductase inhibitors, which possess potential for the treatment of diabetes complications (cataract, nephropathy, neuropathy). Novel 4- thiazolidones are undergoing different stages of clinical trials as potential thyromimetic, antimicrobial, antiviral, anti-ischaermic, cardiovascular, anticancer drugs.
Keywords: heterocyclic systems, cycleconstruction, hydrolysis, ring transformation
Current Organic Chemistry
Title: 4-Thiazolidones: Centenarian History, Current Status and Perspectives for Modern Organic and Medicinal Chemistry
Volume: 8 Issue: 16
Author(s): R. B. Lesyk and B. S. Zimenkovsky
Affiliation:
Keywords: heterocyclic systems, cycleconstruction, hydrolysis, ring transformation
Abstract: The potential of 4-thiazolidones (2,4-thiazolidinediones, 2-thioxo(imino)-4-thiazolidones) as drugs is under consideration by the pharmaceutical science since the beginning of the XX century. During recent years a new phase has been seen in this field. Centerarian history of synthetic research possibilities of these heterocycles lead to diversity in modelling biologically active compounds using 4-thiazolidone scaffolds. Modification of the 4- thiazolidone cycle on 2-, 3-, 4- or 5-position is successful to achieve synthetic products with a wide spectrum of pharmacological activity and has received considerable attention in this review. Currently 4-thiazolidones are considered as a new class of antidiabetic (insulin-sensitising) drugs and potent aldose reductase inhibitors, which possess potential for the treatment of diabetes complications (cataract, nephropathy, neuropathy). Novel 4- thiazolidones are undergoing different stages of clinical trials as potential thyromimetic, antimicrobial, antiviral, anti-ischaermic, cardiovascular, anticancer drugs.
Export Options
About this article
Cite this article as:
Lesyk B. R. and Zimenkovsky S. B., 4-Thiazolidones: Centenarian History, Current Status and Perspectives for Modern Organic and Medicinal Chemistry, Current Organic Chemistry 2004; 8 (16) . https://dx.doi.org/10.2174/1385272043369773
DOI https://dx.doi.org/10.2174/1385272043369773 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Recent Development of Peptide Drugs and Advance on Theory and Methodology of Peptide Inhibitor Design
Medicinal Chemistry Induced Adaptive Resistance to Nitrooxidative Stress in the CNS: Therapeutic Implications
Central Nervous System Agents in Medicinal Chemistry The Unbiased Search of Biomarkers in Neurodegenerative Diseases
Current Pharmaceutical Biotechnology Definitions of Metabolic Syndrome: Where are We Now?
Current Vascular Pharmacology Physio-Pathological Consequences of Marginal or Severe Thiamin Deficiencies in Western Countries and the Potential of Cereal Products in Their Prevention
Current Nutrition & Food Science Preventing Atherosclerosis with Angiotensin-Converting Enzyme Inhibitors: Emphasis on Diabetic Atherosclerosis
Current Drug Targets - Cardiovascular & Hematological Disorders The Role of IRE1 Signaling in the Central Nervous System Diseases
Current Neuropharmacology RNA Therapeutics Directed to the Non Coding Regions of APP mRNA, In Vivo Anti-Amyloid Efficacy of Paroxetine, Erythromycin, and N-acetyl cysteine
Current Alzheimer Research Neurobiology of Depression and Novel Antidepressant Drug Targets
Current Pharmaceutical Design Current Issues in the Use of fMRI-Based Neurofeedback to Relieve Psychiatric Symptoms
Current Pharmaceutical Design Screening of Early and Late Onset Alzheimer’s Disease Genetic Risk Factors in a Cohort of Dementia Patients from Liguria, Italy
Current Alzheimer Research Impact of Nutrition Transition and Resulting Morbidities on Economic and Human Development
Current Diabetes Reviews Neurological Aspects of Medical Use of Cannabidiol
CNS & Neurological Disorders - Drug Targets Chemistry and Biochemistry of Oxidative Stress in Neurodegenerative Disease
Current Medicinal Chemistry Neuroprotective Strategies for Neurological Disorders by Natural Products: An update
Current Neuropharmacology New Trends and Advances in Oral and Maxillofacial Imaging
Current Medical Imaging Sirtuins: Common Targets in Aging and in Neurodegeneration
Current Drug Targets Cell-based Treatment of Cerebral Palsy: Still a Long Way Ahead
Current Stem Cell Research & Therapy The Role of Ketamine in Treatment-Resistant Depression: A Systematic Review
Current Neuropharmacology Targeting ENaC as a Molecular Suspect in Cystic Fibrosis
Current Drug Targets