Abstract
Conduritols are 1,2,3,4-cyclohexenetetrol isomers and exist in ten possible isomeric forms (two mesofour DL-pairs) and have been labelled A, B, C, D, E and F. All of the possible conduritol isomers have already been synthesised starting from completely different materials and their biological importance studied. Transformation of the aromatic compounds into diols has opened up a new synthetic approach to the various conduritol isomers and their derivatives. Conduritols are useful precursors in the preparation of cyclitols such as myo-inositols phosphates and pseudo-sugars, some of which are important mediators in many cellular processes. Conduritol epoxides and aminoconduritols act as inhibitors of glycosidases, cyclophellitols have proven to be potent inhibitors of human immunodeficiency virus (HIV) and glycosidases and conduritol-A analogues modulate the release of insulin. This review is not intended to be exhaustive and is aimed at highlighting the progress in the synthesis of conduritols and their derivatives, as well as their synthetic applications and biological importance mainly in the last decade.
Keywords: cyclitols, conduritols, cyclohexenetetrol isomers, conduritol epoxides, aminoconduritols, glycosidases
Current Organic Chemistry
Title: Cyclitols: Conduritols and Related Compounds
Volume: 8 Issue: 13
Author(s): M. Serdar Gultekin, Murat Celik and Metin Balci
Affiliation:
Keywords: cyclitols, conduritols, cyclohexenetetrol isomers, conduritol epoxides, aminoconduritols, glycosidases
Abstract: Conduritols are 1,2,3,4-cyclohexenetetrol isomers and exist in ten possible isomeric forms (two mesofour DL-pairs) and have been labelled A, B, C, D, E and F. All of the possible conduritol isomers have already been synthesised starting from completely different materials and their biological importance studied. Transformation of the aromatic compounds into diols has opened up a new synthetic approach to the various conduritol isomers and their derivatives. Conduritols are useful precursors in the preparation of cyclitols such as myo-inositols phosphates and pseudo-sugars, some of which are important mediators in many cellular processes. Conduritol epoxides and aminoconduritols act as inhibitors of glycosidases, cyclophellitols have proven to be potent inhibitors of human immunodeficiency virus (HIV) and glycosidases and conduritol-A analogues modulate the release of insulin. This review is not intended to be exhaustive and is aimed at highlighting the progress in the synthesis of conduritols and their derivatives, as well as their synthetic applications and biological importance mainly in the last decade.
Export Options
About this article
Cite this article as:
Gultekin Serdar M., Celik Murat and Balci Metin, Cyclitols: Conduritols and Related Compounds, Current Organic Chemistry 2004; 8 (13) . https://dx.doi.org/10.2174/1385272043370069
DOI https://dx.doi.org/10.2174/1385272043370069 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Insulin Resistance, Small LDL Particles, and Risk for Atherosclerotic Disease
Current Vascular Pharmacology Arterial Stiffness, Pulse Wave Analyses: What Can’t Blood Pressure Tell you in Chronic Kidney Disease
Current Hypertension Reviews Tuberculosis Drug Targets
Current Drug Targets Renal Alterations Promoted By The Lectins From Canavalia Ensiformis (Cona) And Dioclea Guianensis (Dguil) Seeds
Protein & Peptide Letters Targeting STAT1 in Both Cancer and Insulin Resistance Diseases
Current Protein & Peptide Science The Crosstalk Between Insulin and Renin-Angiotensin-Aldosterone Signaling Systems and its Effect on Glucose Metabolism and Diabetes Prevention
Current Vascular Pharmacology Editorial [Hot Topic: New Ligands at 5-HT and DA Receptors for the Treatment of Neuropsychiatric Disorders (Guest Editor: Giuseppe Di Giovanni) ]
Current Topics in Medicinal Chemistry Comparison of Oxidative Stress and Inflammation Induced by Different Intravenous Iron Sucrose Similar Preparations in a Rat Model
Inflammation & Allergy - Drug Targets (Discontinued) Medicinal Plants and Bioactive Compounds for Diabetes Management: Important Advances in Drug Discovery
Current Pharmaceutical Design Editorial [ Recent Advances in the Biochemistry and Treatment of Cysticercosis Guest Editor: Marta C. Romano ]
Current Topics in Medicinal Chemistry Current Updates on Therapeutic Advances in the Management of Cardiovascular Diseases
Current Pharmaceutical Design α<sub>IIb</sub>β<sub>3</sub>-integrin Ligands: Abciximab and Eptifibatide as Proapoptotic Factors in MCF-7 Human Breast Cancer Cells
Current Drug Targets A Case-Control Study Investigating the Effect of MTHFR C677T Variant on Performance of Elite Athletes
Endocrine, Metabolic & Immune Disorders - Drug Targets The Adiponectin Signaling Pathway as a Novel Pharmacological Target
Mini-Reviews in Medicinal Chemistry Induction of Transplantation Tolerance via Regulatory T Cells
Inflammation & Allergy - Drug Targets (Discontinued) Insulin-Degrading Enzyme: A Link Between Alzheimer’s and Type 2 Diabetes Mellitus
CNS & Neurological Disorders - Drug Targets Noscapine-loaded PLA Nanoparticles: Systematic Study of Effect of Formulation and Process Variables on Particle Size, Drug Loading and Entrapment Efficiency
Pharmaceutical Nanotechnology An Update on Clinical and Pharmacological Aspects of Drug-Eluting Stents
Cardiovascular & Hematological Disorders-Drug Targets Concepts of Egr-1 Activation – A Hub for Signal Transduction Cascades
Current Signal Transduction Therapy Selective Molecularly Imprinted Polymer Obtained from a Combinatorial Library for the Extraction of Bisphenol A
Combinatorial Chemistry & High Throughput Screening