Abstract
It is well documented that sensory transmission, including pain, is subject to endogenous inhibitory modulatory influences at dorsal horn of the spinal cord. Recent results, from behavioral to molecular studies, demonstrate that endogenous modulatory systems are bi-phasic, including inhibitory as well as new facilitatory systems. In this review, we propose the existence of endogenous facilitatory systems in the brain, and review evidence supporting the hypothesis. We believe that understanding molecular and cellular mechanisms of endogenous facilitatory systems hold the hope for better future treatment of patients with chronic pain.
Keywords: endogenous modulatory
Current Neurovascular Research
Title: Endogenous Facilitation: From Molecular Mechanisms to Persistent Pain
Volume: 1 Issue: 1
Author(s): Daphne A. Robinson, Amelita A. Calejesan, Feng Wei, Gerald F. Gebhart and Min Zhuo
Affiliation:
Keywords: endogenous modulatory
Abstract: It is well documented that sensory transmission, including pain, is subject to endogenous inhibitory modulatory influences at dorsal horn of the spinal cord. Recent results, from behavioral to molecular studies, demonstrate that endogenous modulatory systems are bi-phasic, including inhibitory as well as new facilitatory systems. In this review, we propose the existence of endogenous facilitatory systems in the brain, and review evidence supporting the hypothesis. We believe that understanding molecular and cellular mechanisms of endogenous facilitatory systems hold the hope for better future treatment of patients with chronic pain.
Export Options
About this article
Cite this article as:
Robinson A. Daphne, Calejesan A. Amelita, Wei Feng, Gebhart F. Gerald and Zhuo Min, Endogenous Facilitation: From Molecular Mechanisms to Persistent Pain, Current Neurovascular Research 2004; 1 (1) . https://dx.doi.org/10.2174/1567202043480189
DOI https://dx.doi.org/10.2174/1567202043480189 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Telomere Shortening Is a Sole Mechanism of Aging in Mammals
Current Aging Science 5'-Nucleotidases, Nucleosides and their Distribution in the Brain: Pathological and Therapeutic Implications
Current Medicinal Chemistry Inflammatory Mediators as Potential Therapeutic Targets in the Spine
Current Drug Targets - Inflammation & Allergy Targeting DNA G-Quadruplex Structures with Peptide Nucleic Acids
Current Pharmaceutical Design Aligned Expression of IFI16 and STING Genes in RRMS Patients’ Blood
Endocrine, Metabolic & Immune Disorders - Drug Targets Telomeric Repeat Containing RNA (TERRA): Aging and Cancer
CNS & Neurological Disorders - Drug Targets Programmed Cell Death Mechanisms in Neurological Disease
Current Molecular Medicine Summary of Research Progress on Bearing Eccentric Loading
Recent Patents on Mechanical Engineering Research on the Pathological Mechanism and Drug Treatment Mechanism of Depression
Current Neuropharmacology CGRP, a Vasodilator Neuropeptide that Stimulates Neuromuscular Transmission and EC Coupling
Current Vascular Pharmacology Turning Tumor-Promoting Copper into an Anti-Cancer Weapon via High-Throughput Chemistry
Current Medicinal Chemistry Editorial [ Medicines Da Vinci Code: Deciphering the Intricate Origins of Clinical Neurovascular Pathology K. Maiese ]
Current Neurovascular Research The Endocannabinoid System and the Treatment of Mood and Anxiety Disorders
CNS & Neurological Disorders - Drug Targets Clinical and Pathophysiological Relations Between Migraine and Mood Disorders
Current Psychiatry Reviews Meet Our Editorial Board Member
Current Alzheimer Research Nanotechnologies: A Strategy to Overcome Blood-Brain Barrier
Current Drug Metabolism Late Effects in Survivors of Childhood CNS Tumors: Review of Results From the Two Largest Survivorship Cooperative Groups
Current Cancer Therapy Reviews A Friend in Need May Not be a Friend Indeed: Role of Microglia in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Intestinal MicrobiOMICS to Define Health and Disease in Human and Mice
Current Pharmaceutical Biotechnology Oxidative Stress in Post-Acute Ischemic Stroke Patients after Intensive Neurorehabilitation
Current Neurovascular Research