Abstract
DRG neurones are a heterogeneous population of neurones that vary in sensory transduction mechanisms, myelination, axon diameter, cell soma size, neurotransmitter content, receptor and ion channel expression. The generation, conduction, integration and transmission of pain signals begin in DRG neurones and they remain an important target for therapeutic intervention in pain disorders. In this review we discuss the expression of cannabinoid receptors in DRG neurones. We will also discuss the actions and molecular mechanisms of cannabinoid receptor ligands in the context of modulating sensory neurone excitability. Evidence suggests that vanilloid and cytokine receptor functions, voltageactivated Ca2+ and K + channels and Ca2+-activated channels are all either direct or indirect sites that might be modulated by synthetic and endogenous cannabinoid ligands.
Keywords: Neurones, heterogeneous, myelination
Current Neuropharmacology
Title: Cannabinoids and Sensory Neurones
Volume: 2 Issue: 1
Author(s): Ruth A. Ross, Rhian M. Evans and Roderick H. Scott
Affiliation:
Keywords: Neurones, heterogeneous, myelination
Abstract: DRG neurones are a heterogeneous population of neurones that vary in sensory transduction mechanisms, myelination, axon diameter, cell soma size, neurotransmitter content, receptor and ion channel expression. The generation, conduction, integration and transmission of pain signals begin in DRG neurones and they remain an important target for therapeutic intervention in pain disorders. In this review we discuss the expression of cannabinoid receptors in DRG neurones. We will also discuss the actions and molecular mechanisms of cannabinoid receptor ligands in the context of modulating sensory neurone excitability. Evidence suggests that vanilloid and cytokine receptor functions, voltageactivated Ca2+ and K + channels and Ca2+-activated channels are all either direct or indirect sites that might be modulated by synthetic and endogenous cannabinoid ligands.
Export Options
About this article
Cite this article as:
Ross A. Ruth, Evans M. Rhian and Scott H. Roderick, Cannabinoids and Sensory Neurones, Current Neuropharmacology 2004; 2 (1) . https://dx.doi.org/10.2174/1570159043476882
DOI https://dx.doi.org/10.2174/1570159043476882 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Recent Advancements in Nanodiamond Mediated Brain Targeted Drug
Delivery and Bioimaging of Brain Ailments: A Holistic Review
Pharmaceutical Nanotechnology Involvement of β-arrestin-2 and Clathrin in Agonist-Mediated Internalization of the Human Cannabinoid CB2 Receptor
Current Molecular Pharmacology New Vessel Formation in the Central Nervous System During Tumor Growth, Vascular Malformations, and Moyamoya
Current Neurovascular Research Kinin Receptors in Vascular Biology and Pathology
Current Vascular Pharmacology Aptamers: Selection, Modification and Application to Nervous System Diseases
Current Medicinal Chemistry Synthesis and In Vitro Evaluation of Some Isatin-Thiazolidinone Hybrid Analogues as Anti-Proliferative Agents
Medicinal Chemistry Intravenous and Regional Paclitaxel Formulations
Current Medicinal Chemistry Topoisomerases and Tubulin Inhibitors: A Promising Combination for Cancer Treatment
Current Medicinal Chemistry - Anti-Cancer Agents Significance of High Levels of Endogenous Melatonin in Mammalian Cerebrospinal Fluid and in the Central Nervous System
Current Neuropharmacology Transferrin Coupled Liposomes for Enhanced Brain Delivery of Doxorubicin
Vascular Disease Prevention (Discontinued) Editorial
Current Radiopharmaceuticals Subject Index To Volume 6
Central Nervous System Agents in Medicinal Chemistry How Immune-inflammatory Processes Link CNS and Psychiatric Disorders: Classification and Treatment Implications
CNS & Neurological Disorders - Drug Targets Treatment of Diffuse-Type Gastric Cancer Cells Using 213Bi-Radioimmunoconjugates In Vitro and In Vivo Following Intraperitoneal Dissemination
Current Radiopharmaceuticals Editorial: Smart Drug Delivery Systems (Part 1)
Current Drug Targets Small Molecule Complementarity As A Source of Novel Pharmaceutical Agents and Combination Therapies
Current Pharmaceutical Design A Mini Review on Interactions Between Neural Stem Cells and Biomaterials
Recent Patents on Regenerative Medicine Novel Therapeutic Approaches Targeting Vascular Endothelial Growth Factor and its Receptors in Haematological Malignancies
Current Cancer Drug Targets Sanguinarine: A Double-Edged Sword of Anticancer and Carcinogenesis and Its Future Application Prospect
Anti-Cancer Agents in Medicinal Chemistry Anesthetic Cardioprotection in Relation to Mitochondria: Basic Science
Current Pharmaceutical Design