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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Biology and Chemistry of Sphingosine-Related Metabolites

Author(s): Martin Brunner and Ari M. P. Koskinen

Volume 8, Issue 17, 2004

Page: [1629 - 1645] Pages: 17

DOI: 10.2174/1385272043369638

Price: $65

Abstract

Metabolites of the thermophilic fungi Myriococcum albomyces and Mycelia sterilia such as myriocin (1), the mycestericins (2-8) and the sphingofungins (13-18) structurally resemble the sphingosines, important components of cell membranes. All the compounds revealed in vitro remarkable immunosuppressive activity and their pharmaceutical potential has led to the development of promising novel immunosuppressants. This review article describes the abundance, biology and chemistry of these metabolites.

Keywords: homologues, sphingosines, myriocin, immunosuppressant, isolation, fermentation, diseases, total syntheses

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