Abstract
O-linked β-N-acetylglucosmaine (O-GlcNAc) is an essential, ubiquitous, dynamic modification of metazoan nucleocytoplasmic proteins. Unlike prototypical glycosylation, O-GlcNAc is not elongated into more complex structures and it is localized almost exclusively to nuclear and cytoplasmic proteins. O-GlcNAc modifies Ser / Thr residues in peptide motifs either identical or similar to those used by kinases. In some instances, O-GlcNAc and phosphorylation occur at the same site, suggesting that a complex interplay exists between these post-translational modifications. Deletion of the gene that adds O-GlcNAc to the protein backbone, the UDP-GlcNAc: polypeptide O-β-Nacetylglucosaminyltransferase, is lethal at the single cell level underlying the importance of O-GlcNAc. O-GlcNAc is rapidly emerging as a key nutrient sensor regulating signaling, transcription and cellular responses to stress.
Keywords: glycosylation, UDP-GlcNAc, phosphorylation, O-b-Nacetylglucosaminyltransferase
Current Organic Chemistry
Title: Nucleocytoplasmic Glycosylation, O-linked β-N-Acetylglucosamine
Volume: 8 Issue: 5
Author(s): N. E. Zachara, W. D. Cheung and G. W. Hart
Affiliation:
Keywords: glycosylation, UDP-GlcNAc, phosphorylation, O-b-Nacetylglucosaminyltransferase
Abstract: O-linked β-N-acetylglucosmaine (O-GlcNAc) is an essential, ubiquitous, dynamic modification of metazoan nucleocytoplasmic proteins. Unlike prototypical glycosylation, O-GlcNAc is not elongated into more complex structures and it is localized almost exclusively to nuclear and cytoplasmic proteins. O-GlcNAc modifies Ser / Thr residues in peptide motifs either identical or similar to those used by kinases. In some instances, O-GlcNAc and phosphorylation occur at the same site, suggesting that a complex interplay exists between these post-translational modifications. Deletion of the gene that adds O-GlcNAc to the protein backbone, the UDP-GlcNAc: polypeptide O-β-Nacetylglucosaminyltransferase, is lethal at the single cell level underlying the importance of O-GlcNAc. O-GlcNAc is rapidly emerging as a key nutrient sensor regulating signaling, transcription and cellular responses to stress.
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Cite this article as:
Zachara E. N., Cheung D. W. and Hart W. G., Nucleocytoplasmic Glycosylation, O-linked β-N-Acetylglucosamine, Current Organic Chemistry 2004; 8 (5) . https://dx.doi.org/10.2174/1385272043485873
DOI https://dx.doi.org/10.2174/1385272043485873 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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