From the Editors Perspective: Aquaporins to Apoptosis

Kenneth      Maiese

Abstract

Our objective for Current Neurovascular Research is to consistently provide a broad platform for leading scientific inquiry of both neuronal and vascular origins in neuroscience. To this end, our current issue is no exception to this rule and offers the opinions and hypotheses of scientific leaders from a broad spectrum of investigative fields. In this issue, the initial article by Lehmann et al. outlines the function of cellular water-selective channels in the central nervous system, termed aquaporins, and the unique role that these channels play in water transport during disorders such as cerebral ischemia, trauma, and neoplasms. Subsequently, the next series of articles in this issue highlight novel therapeutic strategies for a variety of nervous system disorders. Sakamaki presents the molecular mechanisms that can determine vascular endothelial cell injury in conjunction with the cellular and environmental factors that can repair damaged vascular cells and foster new endothelial cell growth during angiogenesis. In another article by Panchal et al., cellular mediators of abnormal

Keywords: Aquaporins, apoptosis, neuropathies