ISSN (Print): 1389-2037
ISSN (Online): 1875-5550
Volume 19, 12 Issues, 2018
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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550
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Editor(s): Claudio Hetz
eISBN: 978-1-60805-013-0, 2009
Neurodegenerative disorders such as Amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD), Prion-related disorders (PrD) and Huntington’s disease (HD) share a common neuropathology, primarily featuring the presence of abnormal protein inclusions containing specific misfolded proteins. These groups of diseases are now classified as Protein Misfolding Disorders. This Ebook gives a comprehensive overview of the possible mechanisms involved in Protein Misfolding Disorders and possible therapeutic strategies to treat these diseases. The Ebook provides the most recent evidence addressing the role of cellular stress responses to neurological diseases, along with therapeutic strategies to alleviate ER stress in a disease context.
Author(s): Emilio Jirillo and Olga Brandonisio
eISBN: 978-1-60805-148-9, 2010
ISBN: 978-1-60805-678-1 ISSN: 2543-215X (Print) ISSN: 1879-744X (Online)
This Ebook provides an interesting and up-to-date overview of Parasite Immunology in terms of a survival battle between hosts and parasites, describing firstly how parasites interact with different B cell compartments and trigger a vigorous antibody response. An Interesting chapter deals with new insights into immune diagnosis in Trypanosoma cruzi infection, while another chapter on malaria vaccines critically reviews their development since the beginning, examining the basis for failures or successes encountered in clinical trials. Chapters on immunological aspects of amoebiasis, giardiasis, toxoplasmosis and leishmaniasis in humans are written by top researchers in the world working in this field. This Ebook should prove to be of interest to researchers and students wishing to familiarize themselves with the latest developments in this field. Therefore, this Ebook is considered essential for all researchers involved in Infectious Diseases, Parasitology, Microbiology, Immunology, and Vaccine design and discovery.
Editor(s): Emilio Jirillo, Thea Magrone and Giuseppe Miragliotta
eISBN: 978-1-60805-985-0, 2014
ISBN: 978-1-60805-989-8 ISSN: 2543-215X (Print) ISSN: 1879-744X (Online)
This volume covers research on the interaction of major helminth parasites with the immune system. The main focus of the e-book is the ability of helminths to subvert host immune responses, on the one hand. On the other hand, the immunological armamentarium of the host against invading parasites is described also in the light of new findings on innate and adaptive immunity. These include the discovery of a new category of lymphocytes, innate lymphoid cells, and the role of T helper cels such as Th1, Th2 and Th3 cells, T regulatory (Treg) and Th17 cells in helminth diseases and inflammation. The balance between these two T cell subsets during the various stages of helminth diseases is also discussed. The book concludes with a review of new therapeutic approaches to combat helminth parasites (biotherapy, vaccines and natural products).
Immunity to Helminths and Novel Therapeutic Approaches provides updated information for medical students, clinicians and researchers in the fields of parasitology, applied immunology and novel drug delivery.
Editor(s): Vaclav Vetvicka
Co-Editor(s): Miroslav Novak
eISBN: 978-1-60805-210-3, 2011
ISBN: 978-1-60805-706-1 ISSN: 2211-0526 (Print)
β-Glucan is generally considered to be a very safe immunomodulator. It is a well-known biological response modifier (BRM) that has been used as an adjuvant therapy for cancer since 1980, mostly in Japan. β-Glucan enhances the innate host defense against certain bacteria, yeast, and viral pathogens. I addition, glucans are also considered to be important in prophylaxis against irradiation. Various types of glucans are now routinely added both to human and animal food. At least 26 clinical trials are currently under way in several countries. The authors of this ebook have selected and brought together information on both theoretical and practical aspects of β-glucan use. The book is suitable for readers seeking timely and precise information on β-glucan history and various biological effects including possible use in the treatment of various diseases, without having any preliminary knowledge of natural immunomodulators. The book should not only provide an inspiration for carbohydrate and clinical chemists for further investigations in biomedicine, but it also presents a number of practical applicable results in immunology
Editor(s): Muhammad Tufail and Makio Takeda
eISBN: 978-1-60805-401-5, 2012
ISBN: 978-1-60805-402-2 ISSN: 2589-3084 (Print) ISSN: 2213-2694 (Online)
Recent molecular studies have revealed an overwhelming role of hemolymph proteins and functional peptides in invertebrate physiology. This is mainly due to the large assortment of biomolecular factors each with a different structure and function. In addition there is a multitude of genes encoding for hemolymph proteins and functional peptides. Hemolymph proteins and functional peptides: Recent Advances in Insects and other Arthropods elucidates the physiological role, both at biochemical and molecular levels, of hemolymph proteins and functional peptides in reproduction, development, homeostasis, hibernation, migration, immune system, and in abiotic stress tolerance of insects and other arthropods. Readers gain an opportunity to find out how insects or other arthropods benefit from these biomolecular instruments for physiological processes, and how they endure and respond to the environmental stress. Recent research developments from a wider range of recognized authors and laboratories actively pursuing research in the field have been gathered and presented in a single volume. This e-book is a unique compilation of research on the biological role of numerous and diversified hemolymph protein molecules and peptides. This e-book will be equally interesting to students and researchers working in universities and other research stations in fields of entomology, zoology and physiology.
Editor(s): Carosena Meola
eISBN: 978-1-60805-143-4, 2012
Infrared thermography (IRT) is a non-contact, non-invasive methodology which allows for detection of thermal energy that is radiated from objects in the infrared band of the electromagnetic spectrum, for conversion of such energy into a visible image (such as a surface temperature map). This feature represents a great potential to be exploited in a vast variety of fields from aerospace to civil engineering, to medicine, to agriculture, etc. However, IRT is still not adequately enclosed in industrial instrumentation and there are still potential users who might benefit from the use of such a technique and who are not aware of their existence.
This e-book conveys information about basic IRT theory, infrared detectors, signal digitalization and applications of infrared thermography in many fields such as medicine, foodstuff conservation, fluid-dynamics, architecture, anthropology, condition monitoring, non destructive testing and evaluation of materials and structures. The volume promotes an exchange of information between the academic world and industry, and shares methodologies which were independently developed and applied in specific disciplines.
Editor(s): Vassilis J. Inglezakis and Antonis A. Zorpas
eISBN: 978-1-60805-261-5, 2012
Handbook of Natural Zeolites provides a comprehensive and updated summary of all important aspects of natural zeolites science and technology. The e-book contains four sections covering the relevant scientific background, established technologies, recent discoveries and future perspectives. All 28 chapters in this handbook are presented by highly respected scientists and leaders in natural zeolites science and include extensive references. The text in this e-book is supported by excellent figures and tables. As a result, novices and established scientists alike will find this comprehensive volume a great resource for years to come.
Editor(s): Rochdi Merzouki
eISBN: 978-1-60805-441-1, 2012
Present day mechatronic systems are designed with synergistic integration of mechanics, electronics and computer technology to produce intelligent devices for the purpose of solving real-world problems. Crucial requirements for a mechatronic system are robustness and fault tolerance, i.e. it should have the ability to process incomplete, imprecise or uncertain information. Such systems often have to work in collaborative environments while being subjected to adverse conditions yet adhering to strict safety standards. This e-book explains the fundamentals of designing such systems from the first principles and how to embed intelligence into them. Examples in this volume are not restricted to production lines, but extend to extreme safety based systems such as space and underwater robotics, autonomous transportation systems, aviation systems and medical robots. Moreover, this e-book also presents recent developments in the design of innovative and intelligent mechatronic systems, applied to robotics and transportation systems, thereby providing an authoritative support for researchers and professionals having basic knowledge in mechatronics.
Author(s): Rita S. Mano
eISBN: 978-1-60805-451-0, 2012
Publications on non profit management reflect three main trends. Some books describe the nonprofit experience in different countries focusing on how these experiences reflect the case of a particular organization in its specific cultural context. These case studies provide an interesting, but not representative, documentation of the issues to be discussed. On the opposite end, other books introduce theoretical approaches and conceptual models that investigate the emergence of the nonprofit phenomenon in a comparative way. Finally, some other books focus on developing the understanding and provide the guidelines on specific themes e.g. accountability, change, marketing etc. Learning Why and How, in contrast to the above, accounts for a comprehensive view of the organizational complexity of management in the nonprofit sector.
This e-book provides a systemic view of nonprofit organizations linking micro and macro level aspects of management. It combines sociological, organizational and psychological elements of organization studies and provides an in-depth understanding of various issues and dilemmas among readers, students and executives of nonprofit organizations and civil society.
Author(s): Joseph Knoll
eISBN: 978-1-60805-470-1, 2012
This e-book is a reference on Selegiline/(-)-Deprenyl effects on the brain.
Selegiline, described in thousands of research papers, is registered in over 60 countries. At present, more than one hundred preparations containing selegiline circulate in the global market under different brand names. They are widely used in the treatment of Parkinson’s disease, Alzheimer’s disease, major depression and as a geroptotective / anti-aging drug.
(-)-Deprenyl/selegiline, the first selective inhibitor of B-type MAO which, in contrast to the known MAO inhibitors, did not potentiate the effect of tyramine but inhibited it. The compound could be combined with levodopa in Parkinson’s disease without signs of hypertensive reactions. The DATATOP study in the USA revealed that (-)-deprenyl delayed the onset of disability associated with early, otherwise untreated Parkinson’s disease. The age-related decay of the supply of the brain with phenylethylamine ( PEA), due to the progressive increase of MAO-B activity in the aging brain, and dopamine, due to the better than average decline of the dopaminergic neuronal activity during the postdevelopmental phase of life, are irresistible biochemical lesions of aging. The speed of deterioration of behavioral performances with the passing of time and longevity depends significantly on the pace of the worsening of these leasions. (-)-Deprenyl, Increasing the supply of the brain with PEA and dopamine, counteracts this aging process. Maintenance of male rats from sexual maturity until death on (-)-deprenyl delays the age-related loss of the capacity to ejaculate, slows the age-related decline of learning ability and prolongs life. In humans, maintenance from sexual maturity on (-)-deprenyl (1 mg daily) is, for the time being, the most promising prophylactic treatment to fight against the age-related decay of behavioral performances, prolonging life, and preventing or delaying the onset of age-related neurodegenerative diseases such as Parkinson’s and Alzheimer’s.
This e-book is a useful reference for graduate medical students, academic researchers in the field of neuropsychopharmacology, neurophysiology and gerontology and professional research groups in commercial organizations manufacturing selegiline preparations.
Editor(s): Shunji Wakamiya
Co-Editor(s): Kazunobu Yamauchi and Hiroyuki Yoshihara
eISBN: 978-1-60805-216-5, 2012
Organizational computing has been critical to the development of medical informatics. Many end user applications (EUAs), such as FileMaker Pro, have been applied to support medical staff work at hospitals in Japan recently.
This e-book describes how to use FileMaker Pro with hospital information systems (HISs). EUAs are described with relation to tools used for development, their functions, coordination methods with HIS, how to use them, their effectiveness, and their problems. While not all of the applications fulfill complete requirements for RASIS, and are not established, they give us new perspectives regarding HISs. This e-book also provides readers with various suggestions on how to use HISs more effectively, how to coordinate EUAs with HIS, how to manage end user applications, and how to achieve clinical effectiveness with EUAs.
This volume is specialized in the use of FileMaker Pro at hospitals and all of the developers of FileMaker Pro systems. The respective authors are medical doctors at various departments of hospitals in contrast to conventional developers who are usually unfamiliar with medical information requirements. These two features make this e-book more clinically significant and facilitate end users to handle HISs more easily.
Editor(s): Raymond J. Waller
eISBN: 978-1-60805-466-4, 2012
ISBN: 978-1-60805-568-5 ISSN: 2468-5828 (Print) ISSN: 2213-5189 (Online)
Behavior problems are approaching epidemic levels in many schools and mental health issues in school-aged children is an international concern. Similarly, parents, caregivers, and other concerned adults report behavioral disturbances in homes and in other settings despite the ongoing effort to ease access to mental health services.
Student mental health has also been demonstrated to have a direct impact on student behavior and performance. This book discusses methods by which educators can promote student mental health, similar to the ways in which schools already promote physical health.
Promoting student mental health may mean doing things differently than are currently being done, but does not involve doing more than what is already is being done. Professional educators, counselors and readers interested in public mental health matters will greatly benefit from this book.