ISSN (Print): 1389-2037
ISSN (Online): 1875-5550
Volume 19, 12 Issues, 2018
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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550
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Ben M. Dunn Department of Biochemistry and Molecular Biology University of Florida College of Medicine, P.O. Box 100245, Gainesville Florida, FL 32610-0245 USA
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Special Issue Submission
Its my pleasure that I got to publish in your journal. Thank you for your supportive mail.
16 Abstract Ahead of Print are available electronically
26 Articles Ahead of Print are available electronically
Protein and peptide based therapy of various human diseases has been the backbone of healthy society. Over the years, this approach has
yielded rich dividends in terms of scientific achievements and medical accomplishments. This hot topic issue covers new emerging trends in
protein and peptide based therapeutic approaches.
The part-I of this issue has incorporated the review articles covering latest updates on the therapeutic role of proteins and peptides in various
human diseases like breast cancer, neurodegenerative disorders like Autism Spectrum Disorders and Alzheimer’s disease, systemic lupus
erythematosus, leprosy, and obesity. One review article explores urotensin based pathophysiological regulation of various disorders. These
articles effectively update the latest findings on the role of protein and peptide based therapeutic approaches for these major human diseases.
Rizvi et al. contributed an article describing therapeutic targeting of amyloid precursor protein and its processing enzymes for breast cancer
Alexiou et al. contributed an article describing several pieces of evidence associated with the correlations of misfolding proteins and neurodegenerative
diseases, and presented computational analysis of the various essential proteins.
Fatima et al. contributed an article describing emerging targets and latest proteomics based therapeutic approaches in neurodegenerative
Alexiou et al. contributed an article describing significant correlations between proteins linked to Autism Spectrum Disorders and Alzheimer’s
Khan et al. contributed an article describing the impact of hydroxyl radical modified-human serum albumin autoantigens in Systemic
Tarique et al. contributed an article describing the role of various subtypes of T-cell and their cytokines in the pathogenesis of leprosy.
Guilherme et al. contributed an article focusing on the genes that confer susceptibility with a perspective on vaccine development to prevent
the rheumatic heart disease.
Queen et al. contributed an article describing the role and mechanism of carbonic anhydrase V in obesity and its therapeutic implications.
Svistunov et al. contributed an article describing the targets at Urotensin system for pharmacological intervention of a number of pathological
statuses and diseases.
These review articles would expectedly make a wonderful read for the researchers and clinicians working for the quest of protein and
peptide based therapeutics.
I, as Guest Editor, would like to express my heartfelt gratitude to the many authors who contributed to this special issue, reporting investigations
on various aspects concerning New Emerging Trends in Protein and Peptide Based Therapeutic Approaches– Part I.
Sarcopenia, the age-related loss of muscle mass and strength/function, is increasingly recognized as a major issue in geriatric
medicine. It is noteworthy that the study of this condition has recently extended beyond the boundaries of geriatrics, highlighting
the relevance of muscle physiology to the overall health status. Indeed, the assessment of sarcopenia is increasingly
invoked as an important tool for the risk stratification of patients suffering from a variety of medical conditions, such as liver
disease, cancer, cardiovascular disease, chronic kidney failure, among others. The wide range of negative health-related events
to which sarcopenia contributes has instigated intensive research efforts in the attempt to decipher its complex pathophysiology
and develop effective treatments. This mini thematic issue has been conceived as a fairly comprehensive overview of the state
of art on sarcopenia, including operational definition, pathogenic processes, candidate biomarkers, and potential therapeutic
interventions [1-6]. The contribution by Ponziani & Gasbarrini  on the relevance of sarcopenia in advanced liver disease has
been included to acknowledge the growing interest in muscle decline outside the original field of geriatric medicine.
The opening article by Landi et al.  provides an overview on current definitions, diagnosis, and treatment of sarcopenia.
Special emphasis is placed on the ongoing debate regarding the need of adopting an univocal definition of sarcopenia as an essential
requisite to promote its clinical implementation and the development of new treatments. As pointed out by Calvani et al.
, the lack of a unique definition of sarcopenia impacts the identification of meaningful biomarkers for the condition. Such a
task is also challenged by the multifaceted and only partly understood pathophysiology of sarcopenia. The complexity of muscle
aging is epitomized by the controversial role played by oxidative stress in this process, as discussed by Fougère et al. .
While the free radical theory of aging provides a strong rationale for the use of antioxidants as a countermeasure for sarcopenia,
the evidence of benefits is still inconclusive. On the other hand, the review by Anton et al.  reports on the efficacy of multimodal
interventions combining exercise and specific nutritional supplementation regimens at improving muscle mass and
strength in old age. β-hydroxy-β-methylbutyrate, a metabolite of leucine, and taurine, a pleiotropic amino acid, are two promising
nutritional agents against age-related muscle loss, as reviewed by Cruz-Jentoft  and Scicchitano & Sica , respectively.
The last contribution discusses the importance of the assessment of sarcopenia in the clinical management of patients with advanced
liver disease . The authors also illustrate similarities and differences in the pathogenesis of sarcopenia of aging and
liver disease-associated muscle wasting.
As the guest editors, we wish that the collection of articles chosen for this mini thematic issue will stimulate the interest not
only of those working in the field, but also of scientists from other biomedical disciplines. Finally, we would like to sincerely
thank all of the authors and referees who have contributed to this issue.
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