Abstract
The completion of the human genome project and the increasing availability of cDNAs to most genes made accessible the possibility of identifying the function of every gene. In contrast to most previous studies which typically examined one or a few human genes at a time for their biological effects, activity, or expression levels, new reagent sets and technological advances now allow large subsets or potentially even all human genes to be studied in a single experiment. Such high throughput approaches not only evaluate expression patterns of known genes, they may also be useful for assigning new activities to genes, placing them in signaling networks not previously known. Functional genomic studies that systematically manipulate either gene overexpression or gene knockdown via RNA interference are particularly useful for gaining global insights into gene function. Expansion of current genomic approaches to phenotypic and functional assays will likely provide new insights into the normal and pathological activities of many genes, undoubtedly accelerating the development of new therapeutic approaches for diagnosing, treating, and preventing disease.
Keywords: bioinformatics, functional genomics, high throughput assays, genome-wide screen
Current Genomics
Title: Global Genomic Approaches to the Study of Human Gene Function
Volume: 5 Issue: 7
Author(s): Peter D. Burbelo, Dana M. Pirone and Kathryn H. Ching
Affiliation:
Keywords: bioinformatics, functional genomics, high throughput assays, genome-wide screen
Abstract: The completion of the human genome project and the increasing availability of cDNAs to most genes made accessible the possibility of identifying the function of every gene. In contrast to most previous studies which typically examined one or a few human genes at a time for their biological effects, activity, or expression levels, new reagent sets and technological advances now allow large subsets or potentially even all human genes to be studied in a single experiment. Such high throughput approaches not only evaluate expression patterns of known genes, they may also be useful for assigning new activities to genes, placing them in signaling networks not previously known. Functional genomic studies that systematically manipulate either gene overexpression or gene knockdown via RNA interference are particularly useful for gaining global insights into gene function. Expansion of current genomic approaches to phenotypic and functional assays will likely provide new insights into the normal and pathological activities of many genes, undoubtedly accelerating the development of new therapeutic approaches for diagnosing, treating, and preventing disease.
Export Options
About this article
Cite this article as:
Burbelo D. Peter, Pirone M. Dana and Ching H. Kathryn, Global Genomic Approaches to the Study of Human Gene Function, Current Genomics 2004; 5 (7) . https://dx.doi.org/10.2174/1389202043348779
DOI https://dx.doi.org/10.2174/1389202043348779 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Natural Sesquiterpene Lactones in the Prevention and Treatment of Inflammatory Disorders and cancer: A Systematic Study of this Emerging Therapeutic Approach based on Chemical and Pharmacological Aspect
Letters in Drug Design & Discovery Natural Carriers for siRNA Delivery
Current Pharmaceutical Design Review of the Applications of Deep Learning in Bioinformatics
Current Bioinformatics Monoclonal Antibodies as Innovative Therapeutics
Current Pharmaceutical Biotechnology Role of Liprins in the Regulation of Tumor Cell Motility and Invasion
Current Cancer Drug Targets Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications
Current Pharmaceutical Design Computational Analysis of Amino Acid Mutation: A Proteome Wide Perspective
Current Proteomics Molecular Pathways of Interferon-Stimulated Gene 15: Implications in Cancer
Current Protein & Peptide Science Clinical Strategies for the Blockade of IL-18 in Inflammatory Bowel Diseases
Current Drug Targets Glycolysis Inhibitors for Anticancer Therapy: A Review of Recent Patents
Recent Patents on Anti-Cancer Drug Discovery Positron Emitting Tracers in Pre-Clinical Drug Development
Current Radiopharmaceuticals Bisphosphonate Therapy for Patients with Breast Cancer
Current Cancer Therapy Reviews Anticoagulant and Fibrinolytic Drugs – Possible Agents in Treatment of Lung Cancer?
Anti-Cancer Agents in Medicinal Chemistry Selective Inhibitors of Inducible Nitric Oxide Synthase: Potential Agents for the Treatment of Inflammatory Diseases?
Current Topics in Medicinal Chemistry Protein Kinases as Drug Targets in Cancer
Current Cancer Drug Targets Insulin-like Growth Factor: Current Concepts and New Developments in Cancer Therapy
Recent Patents on Anti-Cancer Drug Discovery Drug Interactions with Normal and TEN Epidermal Keratinocytes
Current Drug Safety Targeted Therapies in Lung Cancers: Current Landscape and Future Prospects
Recent Patents on Anti-Cancer Drug Discovery EEG Source Localization Using a Genetic Algorithm-Based Artificial Neural Network
Recent Patents on Biomedical Engineering (Discontinued) Tobacco, Inflammation, and Respiratory Tract Cancer
Current Pharmaceutical Design