Abstract
Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.
Keywords: cellular signaling, diseases, ptps, sar, inhibitors, therapeutics/drugs
Current Medicinal Chemistry
Title: Protein Tyrosine Phosphatases and their Inhibitors
Volume: 12 Issue: 1
Author(s): Purushottam M. Dewang, Nai-Mu Hsu, Shao-Zheng Peng and Wen-Ren Li
Affiliation:
Keywords: cellular signaling, diseases, ptps, sar, inhibitors, therapeutics/drugs
Abstract: Protein tyrosine phosphatase (PTP) is the family of enzymes that are key players in cellular signal transduction system and perturbation in their functioning is implicated in many disease-states. Diverse chemical compounds are being synthesized and evaluated as PTP inhibitors. This review presents a brief account of various enzymes of the PTP family and their inhibitors. Peculiar features of these enzymes and their roles in various diseases are summarized along with important inhibitors developed in recent years.
Export Options
About this article
Cite this article as:
Dewang M. Purushottam, Hsu Nai-Mu, Peng Shao-Zheng and Li Wen-Ren, Protein Tyrosine Phosphatases and their Inhibitors, Current Medicinal Chemistry 2005; 12 (1) . https://dx.doi.org/10.2174/0929867053363504
DOI https://dx.doi.org/10.2174/0929867053363504 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Current Drug Nano-targeting Strategies for Improvement in the Diagnosis and Treatment of Prevalent Pathologies such as Cardiovascular and Renal Diseases
Current Drug Targets Antioxidant Effects of Chalcones during the Inflammatory Response: An Overall Review
Current Medicinal Chemistry Engineering Novel Anticoagulant Proteins by Motif Grafting
Protein & Peptide Letters Pharmacology of CCKRs and SAR Studies of Peptidic Analog Ligands
Current Topics in Medicinal Chemistry Novel Benzo[d]imidazole-based Heterocycles as Broad Spectrum Anti-viral Agents: Design, Synthesis and Exploration of Molecular Basis of Action
Mini-Reviews in Medicinal Chemistry Editorial (Thematic Issue: New Developments in Medicinal Chemistry Highlighting Diverse Heterocyclic Ring Systems : Part II - Six Membered Ring Systems)
Current Topics in Medicinal Chemistry COVID-19 and Clinical Trials: Current Challenges and Future Directions
Reviews on Recent Clinical Trials An “Enigmatic” L-Carnosine (β-Alanyl-L-Histidine)? Cell Proliferative Activity as a Fundamental Property of a Natural Dipeptide Inherent to Traditional Antioxidant, Anti-Aging Biological Activities: Balancing and a Hormonally Correct Agent, Novel Patented Oral Therapy Dosage Formulation for Mobility, Skeletal Muscle Power and Functional Performance, Hypothalamic-Pituitary- Brain Relationship in Health, Aging and Stress Studies
Recent Patents on Drug Delivery & Formulation Discovery and Development of GSK3 Inhibitors for the Treatment of Type 2 Diabetes
Current Pharmaceutical Design Microwave Assisted Green Synthesis of Benzimidazole Derivatives and Evaluation of Their Anticonvulsant Activity
Current Microwave Chemistry Influenza and Stroke Risk: A Key Target Not to be Missed?
Infectious Disorders - Drug Targets Chemical Intuition in Drug Design and Discovery
Current Topics in Medicinal Chemistry B Cells: Programmers of CD4 T Cell Responses
Infectious Disorders - Drug Targets Patent Selections
Recent Patents on Anti-Infective Drug Discovery COVID-19: An Update
Recent Advances in Anti-Infective Drug Discovery A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators
Current Organic Chemistry Structure-Activity Relationships of Neuroactive Steroids Acting on the GABAA Receptor
Current Medicinal Chemistry Structural Insights Into Bioactive Thiazolidin-4-one: Experimental and Theoretical Data
Letters in Organic Chemistry A State-of-the-Art Review on Opioids Induced Constipation and its Management
Current Indian Science Herd Immunity Against Coronavirus: A Review
Recent Patents on Biotechnology