Abstract
The spread of cancer cells from the primary tumor to a distant site involves many of the invasive processes normally required for wound healing, including migration through the local connective tissue, invasion of the vasculature, extravasation, invasion of the connective tissue at a distant site, and angiogenesis. Thus, the abilities of tumor cells to invade the host, and to induce endothelial cell invasion and neovascularization, are central to malignant progression. The plasminogen activator system, which plays a direct role in stimulating α5β1 integrin fibronectin receptor-mediated invasion during wound healing, is also very important in tumor cell invasion and metastasis, as well as in angiogenesis. Therefore, the α5β1 receptor and the plasminogen activator system may be promising targets for directed anticancer therapies.
Keywords: fibronectin, invasion, integrins, urokinase, metastasis
Current Cancer Drug Targets
Title: Targeting Invasion Induction as a Therapeutic Strategy for the Treatment of Cancer
Volume: 5 Issue: 7
Author(s): Donna L. Livant
Affiliation:
Keywords: fibronectin, invasion, integrins, urokinase, metastasis
Abstract: The spread of cancer cells from the primary tumor to a distant site involves many of the invasive processes normally required for wound healing, including migration through the local connective tissue, invasion of the vasculature, extravasation, invasion of the connective tissue at a distant site, and angiogenesis. Thus, the abilities of tumor cells to invade the host, and to induce endothelial cell invasion and neovascularization, are central to malignant progression. The plasminogen activator system, which plays a direct role in stimulating α5β1 integrin fibronectin receptor-mediated invasion during wound healing, is also very important in tumor cell invasion and metastasis, as well as in angiogenesis. Therefore, the α5β1 receptor and the plasminogen activator system may be promising targets for directed anticancer therapies.
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Cite this article as:
Livant L. Donna, Targeting Invasion Induction as a Therapeutic Strategy for the Treatment of Cancer, Current Cancer Drug Targets 2005; 5 (7) . https://dx.doi.org/10.2174/156800905774574002
DOI https://dx.doi.org/10.2174/156800905774574002 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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