Abstract
Chemotactic cytokines (chemokines) are a family of small proteins inducing directed cell migration (chemotaxis), via specific G-protein coupled receptors. Initially described as molecules regulating leukocyte recruitment at sites of inflammation, in the last decade, it has become increasingly clear that chemokines mediate several other functions and therefore are more than simple traffick controllers. Chemokines are produced by many different cell types, including tumor cells. Indeed, tumors are major producer of chemokines and have represented an invaluable source for their identification and characterization. In the tumor microenvironment chemokines are crucial regulators of the levels of tumorinfiltrating leukocytes. In addition, these mediators control a variety of biological activities, such as production and deposition of collagen, activation of matrix-digesting enzymes, stimulation of cell growth, inhibition of apoptosis and promotion of neo-angiogenesis. The expression of chemokines, therefore, is of potential advantage for tumor cells and may endow them with enhanced ability to proliferate and disseminate. The complex network of chemokines and their receptors in the tumor microenvironment is currently the object of an intense investigation aimed at targeting these molecules for therapeutic interventions.
Keywords: chemokines, chemokine receptors, chemotaxis, tumor-associated macrophages, tumor-infiltrating leukocytes, tumor stroma, angiogenesis, matrix-metalloproteases, tumor survival, metastasis
Current Cancer Therapy Reviews
Title: The Role of Chemokines and their Receptors in Tumor Progression and Invasion: Potential New Targets of Biological Therapy
Volume: 1 Issue: 1
Author(s): Paola Allavena, Federica Marchesi and Alberto Mantovani
Affiliation:
Keywords: chemokines, chemokine receptors, chemotaxis, tumor-associated macrophages, tumor-infiltrating leukocytes, tumor stroma, angiogenesis, matrix-metalloproteases, tumor survival, metastasis
Abstract: Chemotactic cytokines (chemokines) are a family of small proteins inducing directed cell migration (chemotaxis), via specific G-protein coupled receptors. Initially described as molecules regulating leukocyte recruitment at sites of inflammation, in the last decade, it has become increasingly clear that chemokines mediate several other functions and therefore are more than simple traffick controllers. Chemokines are produced by many different cell types, including tumor cells. Indeed, tumors are major producer of chemokines and have represented an invaluable source for their identification and characterization. In the tumor microenvironment chemokines are crucial regulators of the levels of tumorinfiltrating leukocytes. In addition, these mediators control a variety of biological activities, such as production and deposition of collagen, activation of matrix-digesting enzymes, stimulation of cell growth, inhibition of apoptosis and promotion of neo-angiogenesis. The expression of chemokines, therefore, is of potential advantage for tumor cells and may endow them with enhanced ability to proliferate and disseminate. The complex network of chemokines and their receptors in the tumor microenvironment is currently the object of an intense investigation aimed at targeting these molecules for therapeutic interventions.
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Allavena Paola, Marchesi Federica and Mantovani Alberto, The Role of Chemokines and their Receptors in Tumor Progression and Invasion: Potential New Targets of Biological Therapy, Current Cancer Therapy Reviews 2005; 1 (1) . https://dx.doi.org/10.2174/1573394052952483
DOI https://dx.doi.org/10.2174/1573394052952483 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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