Current Topics in Medicinal Chemistry

Editor-in-Chief:

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

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Most Cited Article

Coumarin Compounds in Medicinal Chemistry: Some Important Examples from the Last Years

Volume:18   Issue:2
Pp: 124-148
Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*
DOI: 10.2174/1568026618666180329115523

Perspective in Medicinal Chemistry promotion: free to download

Volume:18   Issue:23
Pp: 2000-2001
Dorina Lauritano
DOI: 10.2174/156802661823190110112258

Bis-coumarin Derivatives and Their Biological Activities

Volume:18   Issue:2
Pp: 101-113
Qing-Cheng Ren, Chuan Gao, Zhi Xu, Lian-Shun Feng, Ming-Liang Liu*, Xiang Wu* and Feng Zhao*
DOI: 10.2174/1568026618666180221114515

Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer open access plus

Volume:18   Issue:6
Pp: 494-504
Nicholas S. Akins, Tanner C. Nielson and Hoang V. Le*
DOI: 10.2174/1568026618666180523111351

Recent Development of Small Molecule Glutaminase Inhibitors

Volume:18   Issue:6
Pp: 432-443
Minsoo Song*, Soong-Hyun Kim, Chun Young Im and Hee-Jong Hwang
DOI: 10.2174/1568026618666180525100830

Recent Development of Coumarin Derivatives as Potential Antiplasmodial and Antimalarial Agents

Volume:18   Issue:2
Pp: 114-123
Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng and Guang-De Zhang*
DOI: 10.2174/1568026618666171215101158

Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery open access plus

Volume:18   Issue:16
Pp: 1354-1356
Pingyuan Wang and Jia Zhou*
DOI: 10.2174/1568026618666181010101922

Structure-Based Virtual Screening for the Identification of High Affinity Compounds as Potent VEGFR2 Inhibitors for the Treatment of Renal Cell Carcinoma

Volume:18   Issue:25
Pp: 2174-2185
Khushboo Sharma, Khushboo Patidar, Meer Asif Ali, Pravin Patil, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*
DOI: 10.2174/1568026619666181130142237

New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation promotion: free to download

Volume:18   Issue:1
Pp: 75-87
Michelyne Haroun*, Christophe Tratrat, Katerina Kositzi, Evangelia Tsolaki, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Sree Harsha, Athina Geronikaki*, Katharigatta N. Venugopala, Heba S. Elsewedy, Marina Sokovic, Jasna Glamoclija and Ana Ciric
DOI: 10.2174/1568026618666180206101814

Applications of Machine Learning Methods in Drug Toxicity Prediction

Volume:18   Issue:12
Pp: 987-997
Li Zhang, Hui Zhang, Haixin Ai, Huan Hu, Shimeng Li, Jian Zhao and Hongsheng Liu*
DOI: 10.2174/1568026618666180727152557

Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

Volume:18   Issue:8
Pp: 714-746
Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*
DOI: 10.2174/1568026618666180604082610

Backbone-Cyclized Peptides: A Critical Review

Volume:18   Issue:7
Pp: 526-555
Samuel J.S. Rubin and Nir Qvit*
DOI: 10.2174/1568026618666180518092333

Ubiquitin Proteasome System as a Potential Drug Target for Malaria open access plus

Volume:18   Issue:5
Pp: 315-320
Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*
DOI: 10.2174/1568026618666180427145308

Learning from Nature: Bioinspired Strategies Towards Antimicrobial Nanostructured Systems promotion: free to download

Volume:18   Issue:1
Pp: 22-41
Giuseppe Vitiello, Brigida Silvestri and Giuseppina Luciani*
DOI: 10.2174/1568026618666180206101129

Target Enzyme in Alzheimer’s Disease: Acetylcholinesterase Inhibitors

Volume:19   Issue:4
Pp: 264-275
Mridula Saxena* and Ragini Dubey
DOI: 10.2174/1568026619666190128125912

Biological Activities of Artemisinin Derivatives Beyond Malaria

Volume:19   Issue:3
Pp: 205-222
Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen
DOI: 10.2174/1568026619666190122144217

Structure-based Virtual Screening for the Identification of High-affinity Small Molecule Towards STAT3 for the Clinical Treatment of Osteosarcoma

Volume:18   Issue:29
Pp: 2511-2526
Ravina Khandelwal, Aashish Pratap Singh Chauhan, Swarnima Bilawat, Aishwarya Gandhe, Tajamul Hussain, Elizabeth Anne Hood, Anuraj Nayarisseri* and Sanjeev Kumar Singh*
DOI: 10.2174/1568026618666181115092001

Epigenetic Targets and their Inhibitors in Cancer Therapy

Volume:18   Issue:28
Pp: 2395-2419
Le Zhao, Yong-Tao Duan, Ping Lu, Zhi-Juan Zhang, Xiao-Ke Zheng, Jun-Lei Wang* and Wei-Sheng Feng*
DOI: 10.2174/1568026619666181224095449

Tetramethoxyluteolin for the Treatment of Neurodegenerative Diseases

Volume:18   Issue:21
Pp: 1872-1882
Theoharis C. Theoharides* and Irene Tsilioni
DOI: 10.2174/1568026617666181119154247

Advancements in Docking and Molecular Dynamics Simulations Towards Ligand-receptor Interactions and Structure-function Relationships

Volume:18   Issue:20
Pp: 1755-1768
Ahmad Abu Turab Naqvi, Taj Mohammad, Gulam Mustafa Hasan and Md. Imtaiyaz Hassan*
DOI: 10.2174/1568026618666181025114157

Covalent Inhibition in Drug Discovery: Filling the Void in Literature

Volume:18   Issue:13
Pp: 1135-1145
Imane Bjij, Fisayo A. Olotu, Clement Agoni, Emmanuel Adeniji, Shama Khan, Ahmed El Rashedy, Driss Cherqaoui and Mahmoud E.S. Soliman*
DOI: 10.2174/1568026618666180731161438

An Update on MDMX and Dual MDM2/X Inhibitors

Volume:18   Issue:8
Pp: 647-660
Margarida Espadinha, Valentina Barcherini, Elizabeth A. Lopes and Maria M.M. Santos*
DOI: 10.2174/1568026618666180604080119