Current Topics in Medicinal Chemistry

Editor-in-Chief:

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

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Articles Ahead of Print

A Possible Modulation Mechanism of Intramolecular and Intermolecular Interactions for NCAM Polysialylation and Cell Migration

Volume:19
Bo Lu, Xue-Hui Liu, Si-Ming Lia, Zhi-Long Lu, Dong Chen, Frederic A. Troy II, Ri-Bo Huang and Guo-Ping Zhou*

Identifying Cancer Targets Based on Machine Learning Methods via Chou’s 5-steps Rule and General Pseudo Components

Volume:19
Ruirui Liang, Jiayang Xie, Chi Zhang, Mengying Zhang, Hai Huang, Haizhong Huo, Xin Cao and Bing Niu*

Developing Insulin and BDNF Mimetics for Diabetes Therapy

Volume:19
Chi Bun Chan*, Palak Ahuja and Keqiang Ye

STING Activation and its Application in Immuno-Oncology

Volume:19
Yiqian Liana*, Kevin J. Duffya and Jingsong Yang

Recent Advances in Developing K-Ras Plasma Membrane Localization Inhibitors

Volume:19
Na Ye, Qingfeng Xu, Wanwan Li, Pingyuan Wang and Jia Zhou

From Receptor Selectivity to Functional Selectivity: The Rise of Biased Agonism in 5-HT1A Receptor Drug Discovery

Volume:19
Joanna Sniecikowska, Adrian Newman-Tancredi and Marcin Kolaczkowski*

Overview of Current Immunotherapies Targeting Mutated KRAS Cancers

Volume:19
Winfrey Pui Yee Hoo, Pui Yan Siak and Lionel L.A. In*

Antitumoral Potential of Lansbermin-I, a Novel Disintegrin from Porthidium lansbergii lansbergii Venom on Breast Cancer Cells

Volume:19
Leonel Montealegre-Sánchez*, Sarah N. C. Gimenes, Daiana S. Lopes, Samuel C. Teixeira, Luis Solano-Redondo, Veridiana de M. Rodrigues and Eliécer Jiménez-Charris*

KRAS: A Promising Therapeutic Target for Cancer Treatment

Volume:19
Hai-Zhou Wu, Jia-Qi Xiao, Song-Shu Xiao and Yan Cheng*

Bothrops alternatus Snake Venom Induces Cytokine Expression and Oxidative Stress on Renal Function

Volume:19
Francisco Assis Nogueira Júnior, Antonio Rafael Coelho Jorge, Aline Diogo Marinho, João Alison de Moraes Silveira, Natacha Teresa Queiroz Alves, Pedro Henrique Sá Costa, Paula Letícia Braga e Silva, Adriano José Maia Chaves-Filho, Dânya Bandeira Lima, Tiago Lima Sampaio, Glayciane Bezerra de Morais, Janaina Serra Azul Monteiro Evangelista, Alice Maria Costa Martins, Rui Seabra Ferreira Jr., Danielle Silveira Macedo, Roberta Jeane Bezerra Jorge* and Helena Serra Azul Monteiro

Preliminary Biochemical and Venomic Characterization of the Venom of Phalotris lemniscatus (Serpentes, Colubridae)

Volume:19
Jeny Bastida, Alejandro Crampet, Melitta Meneghel and Victor Morais*

Renal Alterations Induced by the Venom of Colombian Scorpion Centruroides Margaritatus

Volume:19
Jessica Dayana Galíndez-Cerón, Roberta Jeane Bezerra Jorge*, Mario H. Chavez-Acosta, Antonio Rafael Coelho Jorge, Natacha Teresa Queiroz Alves, Mara de Moura Gondim Prata, Francisco Adelvane de Paulo Rodrigues, Alexandre Havt, Tiago Lima Sampaio, Alice Maria Costa Martins, Jimmy Alexander Guerrero-Vargas, Helena Serra Azul Monteiro and José T. Beltrán Vidal

Venoms and Isolated Toxins from Snakes of Medical Impact in the Northeast Argentina: State of the Art. Potential Pharmacological Applications

Volume:19
María Emilia Garcia Denegri, Soledad Bustillo, Claudia Carolina Gay, Andrea Van De Velde, Gabriela Gomez, Silvina Echeverría, María Del Carmen Gauna Pereira, Silvana Maruñak, Sandra Nuñez, Fabián Bogado, Matías Sanchez, Gladys Pamela Teibler, Luciano Fusco* and Laura Cristina Ana Leiva*

Isolation, Biochemical Characterization and Antiparasitic Activity of BmatTX-IV, A Basic Lys49-Phospholipase A2 from the Venom of Bothrops mattogrossensis from Paraguay

Volume:19
Jorge Javier Alfonso, Anderson M. Kayanoa, Ana Fidelina Gómez Garay, Rodrigo Simões-Silva, Juliana C. Sobrinho, Santiago Vourliotis, Andreimar M. Soares, Leonardo A. Calderon and Maria Celeste Vega Gómez*

Plants and Phytocompounds Active Against Bothrops Venoms

Volume:19
Roberta Jeane Bezerra Jorge, René Duarte Martins, Renata Mendonça Araújo, Meykson Alexandre da Silva, Helena Serra Azul Monteiro and Rafael Matos Ximenes*

Utilization of the Plant Clusia Fluminensis Planch & Triana Against Some Toxic Activities of the Venom of Bothrops jararaca and B. jararacussu Snake Venom Toxic Activities

Volume:19
Aldo Rodrigues da Silva, Maria Carolina Anholeti, Marcia Pietroluongo, Eladio Flores Sanchez, Alessandra Leda Valverde, Selma Ribeiro de Paiva, Maria Raquel Figueiredo, Maria Auxiliadora Coelho Kaplan and André Lopes Fuly*

Targeting Mutant KRAS for Anticancer Therapy

Volume:19
Fengqian Chen, Martin P. Alphonse, Yan Liu and Qi Liu*

The Application of the RNA Interference Technologies for KRAS: Current Status, Future Perspective and Associated Challenges

Volume:19
Yu-Ting Shao, Li Ma, Tie-Hui Zhang, Tian-Rui Xu, Yuan-Chao Ye* and Ying Liu*

Drug Combinatorial Therapies for the Treatment of KRAS Mutated Lung Cancers

Volume:19
Hao He*, Chang Xu, Zhao Cheng, Xiaoying Qian and Lei Zheng*

microRNAs in Cardiovascular Disease: Small Molecules but Big Roles

Volume:19
Bingqian Yan, Huijing Wang, Yao Tan and Wei Fu*

Antimyotoxic Activity of Synthetic Peptides Derived from Bothrops atrox Snake Gamma Phospholipase A2 Inhibitor Selected by Virtual Screening

Volume:19
J.C. Sobrinho, A.F. Francisco, R. Simões-Silva, A.M. Kayano, J.J. Alfonso, A.F. Gomez, A. Arruda, A.S. Ferreira, A.P.A. Santos, M.B. Luiz, C. B. G. Teles, S. S. Pereira, F.B. Zanchi, L.A. Calderon, J.P. Zuliani and A.M. Soares*

The Anthelmintic Effect on Strongyloides venezuelensis Induced by BnSP- 6, a Lys49-phospholipase A2 Homologue from Bothrops pauloensis Venom

Volume:19
Jéssica Peixoto Rodrigues, Fernanda Van Petten Vasconcelos Azevedo, Mariana Alves Pereira Zoia, Larissa Prado Maia, Lucas Ian Veloso Correia, Julia Maria Costa-Cruz, Veridiana de Melo Rodrigues and Luiz Ricardo Goulart*

Therapeutic Progress and Knowledge Basis on the Natriuretic Peptide System in Heart Failure

Volume:19
Shihui Fu, Zhenyu Chang, Leiming Luo* and Juelin Deng*

Pharmacology of Ivabradine and the Effect on Chronic Heart Failure

Volume:19
Yue Zhou, Jian Wang, Zhuo Meng, Shuang Zhou, Jiayu Peng, Sun Chen, Qingjie Wang* and Kun Sun*

A Review of PCSK9 Inhibitors and their Effects on Cardiovascular Diseases

Volume:19
Bo Chen, Pengjun Zhao*, Xin Shi, Yanping Cui and Aiping Hou

Unfolded Protein Response as a Therapeutic Target in Cardiovascular Disease

Volume:19
Guangyu Zhang, Xiaoding Wang, Thomas G. Gillette, Yingfeng Deng and Zhao V. Wang*