Current Topics in Medicinal Chemistry

Editor-in-Chief:

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

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Foreword: open Access plus

Volume:14   Issue: 1
Pp: 1-1
Allen B. Reitz
DOI: 10.2174/156802661401131226130252

Editorial (Thematic Issue: Nosocomial Infections: An Increasing Challenge to Medicinal Chemistry) open Access plus

Volume:14   Issue: 1
Pp: 2-3
Marcus Tullius Scotti, M. N. D. S. Cordeiro and Alejandro Speck-Planche
DOI: 10.2174/1568026613666131111101521

Structure Guided Design of Biotin Protein Ligase Inhibitors for Antibiotic Discovery open Access plus

Volume:14   Issue: 1
Pp: 4-20
Ashleigh S. Paparella, Tatiana P. Soares da Costa, Min Y. Yap, William Tieu, Matthew C. J. Wilce, Grant W. Booker, Andrew D. Abell and Steven W. Polyak
DOI: 10.2174/1568026613666131111103149

New Synthetic Antibiotics for the Treatment of Enterococcus and Campylobacter Infection open Access plus

Volume:14   Issue: 1
Pp: 21-39
Hai-Wei Xu, Shang-Shang Qin and Hong-Min Liu
DOI: 10.2174/1568026613666131113145544

Designing Type II Topoisomerase Inhibitors: A Molecular Modeling Approach open Access plus

Volume:14   Issue: 1
Pp: 40-50
Juan J. Perez, Cecylia S. Lupala and Patricia Gomez-Gutierrez
DOI: 10.2174/1568026613666131113150046

Structure-and-Mechanism-Based Design and Discovery of Type II Mycobacterium Tuberculosis Dehydroquinate Dehydratase Inhibitors open Access plus

Volume:14   Issue: 1
Pp: 51-63
Yuan Yao and Li Ze-Sheng
DOI: 10.2174/1568026613666131113150257

Docking and PLS Studies on a Set of Thiophenes RNA Polymerase Inhibitors Against Staphylococcus aureus open Access plus

Volume:14   Issue: 1
Pp: 64-80
Luciana Scotti, Edeltrudes de Oliveira Lima, Marcelo Sobral da Silva, Hamilton Ishiki, Igara de Oliveira Lima, Fillipe de Oliveira Pereira, Francisco Jaime Bezerra Mendonça Junior and Marcus Tullius Scotti
DOI: 10.2174/1568026613666131113151347

Next Generation Biofilm Inhibitors for Pseudomonas aeruginosa: Synthesis and Rational Design Approaches open Access plus

Volume:14   Issue: 1
Pp: 81-109
Mahesh S. Majik and Prakash T. Parvatkar
DOI: 10.2174/1568026613666131113152257

Filling the Pipeline - New Drugs for an Old Disease open Access plus

Volume:14   Issue: 1
Pp: 110-129
Matthias Stehr, Ayssar A. Elamin and Mahavir Singh
DOI: 10.2174/1568026613666131113152908

Prospects for Developing New Antibacterials Targeting Bacterial Type IIA Topoisomerases open Access plus

Volume:14   Issue: 1
Pp: 130-151
Tihomir Tomašić and Lucija Peterlin Mašič
DOI: 10.2174/1568026613666131113153251

Progress in the Discovery of Treatments for C. difficile Infection: A Clinical and Medicinal Chemistry Review open Access plus

Volume:14   Issue: 1
Pp: 152-175
Lissa S. Tsutsumi, Yaw B. Owusu, Julian G. Hurdle and Dianqing Sun
DOI: 10.2174/1568026613666131113154753

Computational Medicinal Chemistry for Rational Drug Design: Identification of Novel Chemical Structures with Potential Anti-Tuberculosis Activity open Access plus

Volume:14   Issue: 1
Pp: 176-188
Yuji Koseki and Shunsuke Aoki
DOI: 10.2174/1568026613666131113155042