Current Topics in Medicinal Chemistry


Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA


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Editorial (Thematic Issue: The Medicinal Chemistry of the Cytochrome P450s) promotion: free to download

Volume:13   Issue: 18
Pp: 2217-2217
Matthew Sykes
DOI: 10.2174/15680266113136660154

Overview on Theoretical Studies Discriminating the Two-Oxidant Versus Two-State-Reactivity Models for Substrate Monoxygenation by Cytochrome P450 Enzymes open access plus

Volume:13   Issue: 18
Pp: 2218-2232
Sam P. de Visser, Cristina S. Porro, Matthew G. Quesne, Mala A. Sainna and Andrew W. Munro
DOI: 10.2174/15680266113136660155

Generation, Validation, and Application of a P450 Homology Model

Volume:13   Issue: 18
Pp: 2233-2240
Benjamin C. Lewis and John O. Miners
DOI: 10.2174/15680266113136660156

Cytochrome P450 2C8 and Drug Metabolism

Volume:13   Issue: 18
Pp: 2241-2253
Xiaoping Lv, Fangfang Zhong and Xiangshi Tan
DOI: 10.2174/15680266113136660157

The Evolution of Cytochrome P450 Enzymes as Biocatalysts in Drug Discovery and Development

Volume:13   Issue: 18
Pp: 2254-2280
Elizabeth M.J. Gillam and Martin A. Hayes
DOI: 10.2174/15680266113136660158

Editorial (Thematic Issue: New Therapeutic Bearings for Repositioned Drugs) promotion: free to download

Volume:13   Issue: 18
Pp: 2281-2282
Kevin B. Clark
DOI: 10.2174/15680266113136660159

Minocycline Repurposing in Critical Illness: Focus on Stroke

Volume:13   Issue: 18
Pp: 2283-2290
T. Vivian Liao, Christy C. Forehand, David C. Hess and Susan C. Fagan
DOI: 10.2174/15680266113136660160

Calcium Antagonists: A Ready Prescription for Treating Infectious Diseases?

Volume:13   Issue: 18
Pp: 2291-2305
Kevin B. Clark, Edward M. Eisenstein and Scott E. Krahl
DOI: 10.2174/15680266113136660161

Discovering New Treatments for Alzheimer's Disease by Repurposing Approved Medications

Volume:13   Issue: 18
Pp: 2306-2327
Brian S. Appleby and Jeffrey L. Cummings
DOI: 10.2174/15680266113136660162

Drug Repurposing: Translational Pharmacology, Chemistry, Computers and the Clinic open access plus

Volume:13   Issue: 18
Pp: 2328-2336
Naiem T. Issa, Stephen W. Byers and Sivanesan Dakshanamurthy
DOI: 10.2174/15680266113136660163

Drug Repositioning for Treatment of Movement Disorders: From Serendipity to Rational Discovery Strategies

Volume:13   Issue: 18
Pp: 2337-2363
Bence Bolgár, Ádám Arany, Gergely Temesi, Balázs Balogh, Péter Antal and Péter Mátyus
DOI: 10.2174/15680266113136660164

Repurposed Drugs for the Treatment of Schizophrenia and Bipolar Disorders

Volume:13   Issue: 18
Pp: 2364-2385
J. M. Bumb, F. Enning and F. M. Leweke
DOI: 10.2174/15680266113136660165

Repurposed Drugs in Metabolic Disorders

Volume:13   Issue: 18
Pp: 2386-2394
Josef Finsterer and Marlies Frank
DOI: 10.2174/15680266113136660166