Abstract
The progress in both peptide and polymer chemistry has led to the preparation of “hybrids” to yield compounds with properties not achievable with the separate components. In this review we aim at describing the current synthetic methodologies for the preparation of peptide containing block copolymers, either being completely peptidic or as hybrids with synthetic polymer blocks. The different techniques to prepare these polymers are ordered by level of control over peptide sequence and hence their molecular structure. First, recent developments in NCA polymerization will be discussed, which enable the construction of well-defined high molecular weight peptide based block copolymers, albeit with no absolute control over amino acid composition. Solution phase peptide synthesis allows the preparation of small peptide sequences, which can be incorporated into the side chain or the main chain of hybrid polymer architectures. Application of solid phase peptide synthesis and the newly developed peptide ligation methods has resulted in an extension of the length of the peptide fragments that can be conveniently incorporated into hybrid polymer structures. Finally absolute control over amino acid sequence, combined with the ability to create high molecular weight species is accomplished with the application of protein engineering to the field of polymer science.
Keywords: polymer chemistry, homopolypeptide, atom transfer radical polymerization (atrp), peptide transduction domain (ptd), chromatography, maldi-tof, epitopes
Current Organic Chemistry
Title: Peptide-Containing Block Copolymers: Synthesis and Potential Applications of Bio-Mimetic Materials
Volume: 9 Issue: 12
Author(s): J. M. Smeenk, D. W.P.M. Lowik and J. C.M. van Hest
Affiliation:
Keywords: polymer chemistry, homopolypeptide, atom transfer radical polymerization (atrp), peptide transduction domain (ptd), chromatography, maldi-tof, epitopes
Abstract: The progress in both peptide and polymer chemistry has led to the preparation of “hybrids” to yield compounds with properties not achievable with the separate components. In this review we aim at describing the current synthetic methodologies for the preparation of peptide containing block copolymers, either being completely peptidic or as hybrids with synthetic polymer blocks. The different techniques to prepare these polymers are ordered by level of control over peptide sequence and hence their molecular structure. First, recent developments in NCA polymerization will be discussed, which enable the construction of well-defined high molecular weight peptide based block copolymers, albeit with no absolute control over amino acid composition. Solution phase peptide synthesis allows the preparation of small peptide sequences, which can be incorporated into the side chain or the main chain of hybrid polymer architectures. Application of solid phase peptide synthesis and the newly developed peptide ligation methods has resulted in an extension of the length of the peptide fragments that can be conveniently incorporated into hybrid polymer structures. Finally absolute control over amino acid sequence, combined with the ability to create high molecular weight species is accomplished with the application of protein engineering to the field of polymer science.
Export Options
About this article
Cite this article as:
Smeenk M. J., Lowik W.P.M. D. and van Hest C.M. J., Peptide-Containing Block Copolymers: Synthesis and Potential Applications of Bio-Mimetic Materials, Current Organic Chemistry 2005; 9 (12) . https://dx.doi.org/10.2174/1385272054553622
DOI https://dx.doi.org/10.2174/1385272054553622 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Restoring the Dysfunctional Endothelium
Current Pharmaceutical Design Recent Contributions of Elastin-Like Recombinamers to Biomedicine and Nanotechnology
Current Topics in Medicinal Chemistry Extrahepatic Targets and Cellular Reactivity of Drug Metabolites
Current Medicinal Chemistry Atopic Dermatitis and Cytokines: Recent Patents in Immunoregulatory and Therapeutic Implications of Cytokines in Atopic Dermatitis - Part I: Cytokines in Atopic Dermatitis
Recent Patents on Inflammation & Allergy Drug Discovery Beta-arrestin Biased Agonism/Antagonism at Cardiovascular Seven Transmembrane-spanning Receptors
Current Pharmaceutical Design Manipulating the Ability of Substituted Titanocene Derivatives to Induce Apoptosis in Castrate-Resistant Prostate Cancer Cells
Letters in Drug Design & Discovery Anti-Angiogenic Agents in Pancreatic Cancer: A Review
Anti-Cancer Agents in Medicinal Chemistry Wnt Signaling in Angiogenesis
Current Drug Targets Magnetic Nanoparticles for MRI of Brain Tumors
Current Pharmaceutical Biotechnology Exploring the Potential of NO-Independent Stimulators and Activators of Soluble Guanylate Cyclase for the Medical Treatment of Erectile Dysfunction
Current Pharmaceutical Design Antiglycation Activity of Triazole Schiff’s Bases Against Fructosemediated Glycation: In Vitro and In Silico Study
Medicinal Chemistry CGRP Receptor Antagonists: Toward a Novel Migraine Therapy
Current Pharmaceutical Biotechnology Algae Biotechnology – Green Cell-Factories on the Rise
Current Biotechnology Neurocysticercosis: The Enigmatic Disease
Central Nervous System Agents in Medicinal Chemistry Concerns and Hopes for Stem Cell Therapy in Cardiology: Focus on Endothelial Progenitor Cells
Cardiovascular & Hematological Disorders-Drug Targets Novel Targets for Antiinflammatory and Antiarthritic Agents
Current Pharmaceutical Design State of the Art Clinical Efficacy and Safety Evaluation of N-Acetylcarnosine Dipeptide Ophthalmic Prodrug. Principles for the Delivery, Self-Bioactivation, Molecular Targets and Interaction with a Highly Evolved Histidyl-Hydrazide Structure in the Treatment and Therapeutic Management of a Group of Sight-Threatening Eye Diseases
Current Clinical Pharmacology Neuroprotective Effects of Tetracyclines: Molecular Targets, Animal Models and Human Disease
CNS & Neurological Disorders - Drug Targets Under the Microscope: Focus on Chlamydia pneumoniae Infection and Multiple Sclerosis
Current Neurovascular Research Vacuolar H+-ATPase Signaling Pathway in Cancer
Current Protein & Peptide Science