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Current Genomics

Editor-in-Chief

ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Genes Involved in Apoptosis Regulation: Implications for Cancer Therapy

Author(s): Simone Fulda and Klaus-Michael Debatin

Volume 6, Issue 8, 2005

Page: [609 - 611] Pages: 3

DOI: 10.2174/138920205775811407

Price: $65

Abstract

Apoptosis, the cells intrinsic death program, plays an important role in the regulation of tissue homeostasis. Also, killing of cancer cells by various cytotoxic approaches such as anticancer drugs, γ-irradiation, suicide genes or immunotherapy, is predominantly mediated through induction of apoptosis in target cells. Understanding the molecular events that regulate apoptosis and how tumor cells evade apoptotic deletion have provided a paradigm to link cancer genetics and response to cancer therapy. Thus, insights into the mechanisms regulating drug-induced apoptosis provide rational targets for novel therapeutic interventions.

Keywords: Apoptosis, cancer, IAP, Bcl-2


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