Protective Antibodies and Endemic Dimorphic Fungi

J.   D.   Nosanchuk

Abstract

The host response to infection is the outcome of a complex interaction between a microbe and a hosts innate and adaptive immune system. In this context, the role of antibody in the endemic mycoses is relatively poorly understood. Recently, a monoclonal antibody to a cell surface protein has been shown to be protective in a murine histoplasmosis model. The findings with Histoplasma capsulatum may provide a paradigm for antibody protection against endemic fungi. This paper reviews the recent data on protective antibody in histoplasmosis and previous data supporting a role for antibody in protective responses in other dimorphic fungi.

Keywords: histoplasma capsulatum, antibody, pathogenesis

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