Abstract
Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human immunodeficiency virus (HIV), antibacterial, antimalarial, antiinflammatory, anthelmintic and antioxidant properties. This article reports a survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990s to the beginning of 2003. A broad range of medical and pharmaceutical disciplines are covered, including a brief introduction about discovery, phytochemical aspects, organic synthesis, anti-HIV and cytotoxic mechanisms of action. Various structural modifications carried out and their biological and pharmacokinetic profiles are also incorporated.
Keywords: betulinic acid, anti-hiv derivatives, anti-hiv mechanism, anticancer derivatives, anticancer mechanism, antiinflammatory, antimalarial, biotransformation
Current Medicinal Chemistry
Title: Betulinic Acid and Its Derivatives: A Review on their Biological Properties
Volume: 12 Issue: 6
Author(s): Perumal Yogeeswari and Dharmarajan Sriram
Affiliation:
Keywords: betulinic acid, anti-hiv derivatives, anti-hiv mechanism, anticancer derivatives, anticancer mechanism, antiinflammatory, antimalarial, biotransformation
Abstract: Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human immunodeficiency virus (HIV), antibacterial, antimalarial, antiinflammatory, anthelmintic and antioxidant properties. This article reports a survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990s to the beginning of 2003. A broad range of medical and pharmaceutical disciplines are covered, including a brief introduction about discovery, phytochemical aspects, organic synthesis, anti-HIV and cytotoxic mechanisms of action. Various structural modifications carried out and their biological and pharmacokinetic profiles are also incorporated.
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Cite this article as:
Yogeeswari Perumal and Sriram Dharmarajan, Betulinic Acid and Its Derivatives: A Review on their Biological Properties, Current Medicinal Chemistry 2005; 12 (6) . https://dx.doi.org/10.2174/0929867053202214
DOI https://dx.doi.org/10.2174/0929867053202214 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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