Abstract
Tuberculosis vaccine research began with the search for a vaccine that might be better than, and thus could replace, the current Bacillus Calmette Guérin (BCG) vaccine. Over the last fifteen years or so, intense research effort has led to the identification of a number of novel tuberculosis (TB) vaccines which can be divided into 4 categories: genetically modified mycobacteria, protein, plasmid DNA and viral. However, it is increasingly believed that the current BCG vaccine will continue to be used as a childhood vaccine and that more effort should be directed to developing appropriate boosting vaccines. Mounting evidence suggests that recombinant genetic vaccines, particularly recombinant viral vaccines, are effective in boosting immune activation and protection by BCG vaccination. Since modified vaccinia virus Ankara (MVA)- and adenovirus-vectored TB vaccines have been most extensively studied, this review will focus on recent advances in the development and applications of these two viral TB vaccines.
Keywords: modified vaccinia virus Ankara, cmv promoters, gag gene, bcg vaccination, bovine models, genetically modified dendritic cell, immunopathology
Current Gene Therapy
Title: Recent Advances in the Development of Adenovirus- and Poxvirus- Vectored Tuberculosis Vaccines
Volume: 5 Issue: 5
Author(s): Zhou Xing, Michael Santosuosso, Sarah McCormick, Teng-Chih Yang, James Millar, Mary Hitt, Yonghong Wan, Jonathan Bramson and H. M. Vordermeier
Affiliation:
Keywords: modified vaccinia virus Ankara, cmv promoters, gag gene, bcg vaccination, bovine models, genetically modified dendritic cell, immunopathology
Abstract: Tuberculosis vaccine research began with the search for a vaccine that might be better than, and thus could replace, the current Bacillus Calmette Guérin (BCG) vaccine. Over the last fifteen years or so, intense research effort has led to the identification of a number of novel tuberculosis (TB) vaccines which can be divided into 4 categories: genetically modified mycobacteria, protein, plasmid DNA and viral. However, it is increasingly believed that the current BCG vaccine will continue to be used as a childhood vaccine and that more effort should be directed to developing appropriate boosting vaccines. Mounting evidence suggests that recombinant genetic vaccines, particularly recombinant viral vaccines, are effective in boosting immune activation and protection by BCG vaccination. Since modified vaccinia virus Ankara (MVA)- and adenovirus-vectored TB vaccines have been most extensively studied, this review will focus on recent advances in the development and applications of these two viral TB vaccines.
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Xing Zhou, Santosuosso Michael, McCormick Sarah, Yang Teng-Chih, Millar James, Hitt Mary, Wan Yonghong, Bramson Jonathan and Vordermeier M. H., Recent Advances in the Development of Adenovirus- and Poxvirus- Vectored Tuberculosis Vaccines, Current Gene Therapy 2005; 5 (5) . https://dx.doi.org/10.2174/156652305774329230
DOI https://dx.doi.org/10.2174/156652305774329230 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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