Abstract
Prostaglandins (PGs) are a very important class of naturally occurring physiologically active substances, which have been the subject of continuous attention by biologists, pharmacists and chemists since their discovery in the 1930s. Pharmacological studies have shown that prostaglandins exhibit an extremely broad spectrum of activity such as on the smooth muscles of various organs, their mediating role in the central and peripheral nervous systems, in inflammatory processes, and their hormone-like and antihormonal activities. Due to the diversified biological activity and rapid metabolism of the natural prostaglandins, a lot of effort has been done to synthesize prostaglandin analogs. Particularly interesting are the prostaglandin analogs containing heteroatoms in the cyclopentane ring which have received a great deal of attention in relation to their potential biological properties and diversified biological activity. This article is dedicated to Prof. Sune K. Bergstrom (in memoriam) for his milestone contributions to prostaglandin research.
Keywords: cyclooxygenase, cyclopentanoic system, prostacyclin, thromboxane, prostanoids, corticosteroids
Current Organic Chemistry
Title: Synthesis and Biological Activity of Prostaglandin Analogs Containing Heteroatoms in the Cyclopentane Ring
Volume: 9 Issue: 5
Author(s): Francisco C. Biaggio, Alessandra R. Rufino, Marcio H. Zaim, Cristiane Y. H. Zaim, Mauro A. Bueno and Alessandro Rodrigues
Affiliation:
Keywords: cyclooxygenase, cyclopentanoic system, prostacyclin, thromboxane, prostanoids, corticosteroids
Abstract: Prostaglandins (PGs) are a very important class of naturally occurring physiologically active substances, which have been the subject of continuous attention by biologists, pharmacists and chemists since their discovery in the 1930s. Pharmacological studies have shown that prostaglandins exhibit an extremely broad spectrum of activity such as on the smooth muscles of various organs, their mediating role in the central and peripheral nervous systems, in inflammatory processes, and their hormone-like and antihormonal activities. Due to the diversified biological activity and rapid metabolism of the natural prostaglandins, a lot of effort has been done to synthesize prostaglandin analogs. Particularly interesting are the prostaglandin analogs containing heteroatoms in the cyclopentane ring which have received a great deal of attention in relation to their potential biological properties and diversified biological activity. This article is dedicated to Prof. Sune K. Bergstrom (in memoriam) for his milestone contributions to prostaglandin research.
Export Options
About this article
Cite this article as:
Biaggio C. Francisco, Rufino R. Alessandra, Zaim H. Marcio, Zaim Y. H. Cristiane, Bueno A. Mauro and Rodrigues Alessandro, Synthesis and Biological Activity of Prostaglandin Analogs Containing Heteroatoms in the Cyclopentane Ring, Current Organic Chemistry 2005; 9 (5) . https://dx.doi.org/10.2174/1385272053174912
DOI https://dx.doi.org/10.2174/1385272053174912 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cardiovascular Therapeutics Targets on the NO–sGC–cGMP Signaling Pathway: A Critical Overview
Current Drug Targets New Challenges and Strategies for Cardiac Disease: Autophagy, mTOR, and AMP-activated Protein Kinase
Current Neurovascular Research Antioxidative Peptides: Trends and Perspectives for Future Research
Current Medicinal Chemistry Targeting Kinin Receptors for the Treatment of Neurological Diseases
Current Pharmaceutical Design Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Therapeutics: Rationales, Controversies, Clinical Experience
Current Drug Targets Mechanisms Involved in Neuroprotective Effects of Transcranial Magnetic Stimulation
CNS & Neurological Disorders - Drug Targets Directions for Enhancement of the Therapeutic Efficacy of Mesenchymal Stem Cells in Different Neurodegenerative and Cardiovascular Diseases: Current Status and Future Perspectives
Current Stem Cell Research & Therapy Editorial (Thematic Issue: Measuring Myocyte Oxidative Stress and Targeting Cytokines to Evaluate Inflammatory Response and Cardiac Repair after Myocardial Infarction)
Current Vascular Pharmacology Mechanisms of the Penetration of Blood-Borne Substances into the Brain
Current Neuropharmacology Thiazolidinediones and Cardiovascular Risk — A Question of Balance
Current Cardiology Reviews Cross-Talk Between NO Synthase Isoforms in Neuro-Inflammation: Possible Implications in HIV-Associated Neurocognitive Disorders
Current Medicinal Chemistry Platelet in Progression of Atherosclerosis: A Potential Target in Diabetic Patients
Current Diabetes Reviews An Insight Into Mitochondrial Dysfunction and its Implications in Neurological Diseases
Current Drug Targets Exploring New CGRP Family Peptides and their Receptors in Vertebrates
Current Protein & Peptide Science Phosphodiesterase Inhibitors as Therapeutics for Traumatic Brain Injury
Current Pharmaceutical Design Neoangiogenesis Induced by Progenitor Endothelial Cells: Effect of Fucoidan from Marine Algae
Cardiovascular & Hematological Agents in Medicinal Chemistry Epoxyeicosatrienoic Acid Analogs and Vascular Function
Current Medicinal Chemistry Subject Index to Volume 4
Current Drug Targets Antagonists of the Vasopressin V1 Receptor and of the β<sub>1</sub>-Adrenoceptor Inhibit Cytotoxic Brain Edema in Stroke by Effects on Astrocytes-but the Mechanisms Differ
Current Neuropharmacology Proteasome Inhibition in Transplantation-Focusing on the Experience with Bortezomib
Current Pharmaceutical Design