Abstract
Recently, the spectrum of molecular imaging devices such as positron emission tomography (PET) was further expanded by the now clinically available combined imaging modalities such as PET-CT and the preclinically used small animal PET scanners. These are powerful tools that can bridge the gap between preclinical and clinical evaluation studies of new radiotracers for molecular imaging of healthy and diseased states in vivo. The β-adrenoceptor (β-AR) radioligands discussed in this review represent a class of molecular probes for the non-invasive in vivo assessment of β-AR density eg. in the heart with PET. The β-AR radioligands (S)- [11C]CGP 12177 (1) or (S)-[11C]CGP 12388 (2) are currently investigated in clinical studies with PET. Additionally, subtype-selective b1-AR radioligands are used in preclinical research which show potential for the diagnostics of the "β1-AR organ" as such the heart can be defined. Non-invasive quantification of β-ARs could facilitate the accurate choice and control of therapeutic interventions. Here we summarize the state-ofthe- art of the radiochemistry of radioactive β-AR radioligands.
Keywords: molecular imaging, adrenoceptor radioligand, subtype-selective b-adrenoceptor radioligand, diagnostics in nuclear medicine, positron emission tomography pet, scintigraphy, receptor imaging in vivo
Current Medicinal Chemistry
Title: Non-Invasive Molecular Imaging of β-Adrenoceptors In Vivo: Perspectives for PET-Radioligands
Volume: 12 Issue: 18
Author(s): K. Kopka, M. P. Law, H.- J. Breyholz, A. Faust, C. Holtke, B. Riemann, O. Schober, M. Schafers and S. Wagner
Affiliation:
Keywords: molecular imaging, adrenoceptor radioligand, subtype-selective b-adrenoceptor radioligand, diagnostics in nuclear medicine, positron emission tomography pet, scintigraphy, receptor imaging in vivo
Abstract: Recently, the spectrum of molecular imaging devices such as positron emission tomography (PET) was further expanded by the now clinically available combined imaging modalities such as PET-CT and the preclinically used small animal PET scanners. These are powerful tools that can bridge the gap between preclinical and clinical evaluation studies of new radiotracers for molecular imaging of healthy and diseased states in vivo. The β-adrenoceptor (β-AR) radioligands discussed in this review represent a class of molecular probes for the non-invasive in vivo assessment of β-AR density eg. in the heart with PET. The β-AR radioligands (S)- [11C]CGP 12177 (1) or (S)-[11C]CGP 12388 (2) are currently investigated in clinical studies with PET. Additionally, subtype-selective b1-AR radioligands are used in preclinical research which show potential for the diagnostics of the "β1-AR organ" as such the heart can be defined. Non-invasive quantification of β-ARs could facilitate the accurate choice and control of therapeutic interventions. Here we summarize the state-ofthe- art of the radiochemistry of radioactive β-AR radioligands.
Export Options
About this article
Cite this article as:
Kopka K., Law P. M., Breyholz J. H.-, Faust A., Holtke C., Riemann B., Schober O., Schafers M. and Wagner S., Non-Invasive Molecular Imaging of β-Adrenoceptors In Vivo: Perspectives for PET-Radioligands, Current Medicinal Chemistry 2005; 12 (18) . https://dx.doi.org/10.2174/0929867054637608
DOI https://dx.doi.org/10.2174/0929867054637608 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements