Abstract
The recognition that asthma is an inflammatory disease opens a new field to find effective models for the evaluation and development of new drugs. In this scenario, many novel candidate molecules have been shown to work perfectly in animal models, but not in clinical studies. Ancillary models are reviewed in association with the findings obtained in either transgenic or knockout mice. In parallel, genetic studies in animal models and human populations have identified several genes that are asthma-related. Knowledge of these recent findings, in parallel with pharmacogenomic studies will be necessary to direct new strategies for the development of novel drugs to treat subgroups of patients with asthma.
Keywords: asthma, animal models, genetic studies
Current Pharmaceutical Design
Title: The Puzzle of Asthma Treatment: Animal Models to Genetic Studies
Volume: 11 Issue: 19
Author(s): T. S. Frode and Y. S. Medeiros
Affiliation:
Keywords: asthma, animal models, genetic studies
Abstract: The recognition that asthma is an inflammatory disease opens a new field to find effective models for the evaluation and development of new drugs. In this scenario, many novel candidate molecules have been shown to work perfectly in animal models, but not in clinical studies. Ancillary models are reviewed in association with the findings obtained in either transgenic or knockout mice. In parallel, genetic studies in animal models and human populations have identified several genes that are asthma-related. Knowledge of these recent findings, in parallel with pharmacogenomic studies will be necessary to direct new strategies for the development of novel drugs to treat subgroups of patients with asthma.
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Cite this article as:
Frode S. T. and Medeiros S. Y., The Puzzle of Asthma Treatment: Animal Models to Genetic Studies, Current Pharmaceutical Design 2005; 11 (19) . https://dx.doi.org/10.2174/1381612054367517
DOI https://dx.doi.org/10.2174/1381612054367517 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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