Abstract
Spinal cord trauma activates the immune system and elicits leukocyte recruitment to the site of injury. This increase in immunological activity contributes to acute lesion expansion over a period of days to weeks following the initial trauma. At the same time, inflammatory cells and mediators facilitate endogenous repair processes such as axonal sprouting and remyelination. Thus, to be effective, therapies that target the immune system must limit the destructive effects of neutrophil, macrophage and lymphocyte activation, while simultaneously preserving their reparative functions.
Keywords: inflammation, spinal cord injury, neuroprotection, immunology, pathology
Current Pharmaceutical Design
Title: Inflammatory-Mediated Injury and Repair in the Traumatically Injured Spinal Cord
Volume: 11 Issue: 10
Author(s): T. B. Jones, E. E. McDaniel and P. G. Popovich
Affiliation:
Keywords: inflammation, spinal cord injury, neuroprotection, immunology, pathology
Abstract: Spinal cord trauma activates the immune system and elicits leukocyte recruitment to the site of injury. This increase in immunological activity contributes to acute lesion expansion over a period of days to weeks following the initial trauma. At the same time, inflammatory cells and mediators facilitate endogenous repair processes such as axonal sprouting and remyelination. Thus, to be effective, therapies that target the immune system must limit the destructive effects of neutrophil, macrophage and lymphocyte activation, while simultaneously preserving their reparative functions.
Export Options
About this article
Cite this article as:
Jones B. T., McDaniel E. E. and Popovich G. P., Inflammatory-Mediated Injury and Repair in the Traumatically Injured Spinal Cord, Current Pharmaceutical Design 2005; 11 (10) . https://dx.doi.org/10.2174/1381612053507468
DOI https://dx.doi.org/10.2174/1381612053507468 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Gene Therapy Approaches to Ataxias
Current Gene Therapy Gut-brain Axis: Role of Lipids in the Regulation of Inflammation, Pain and CNS Diseases
Current Medicinal Chemistry Sexual Dimorphism in Autoimmune Disease
Current Molecular Medicine Human Model Neurons in Studies of Brain Cell Damage and Neural Repair
Current Molecular Medicine The Role of Neurotrophins in Axonal Growth, Guidance, and Regeneration
Current Neurovascular Research Overview and Findings from the Religious Orders Study
Current Alzheimer Research Quantitative Imaging Biomarkers and their Emerging Role
Current Medical Imaging Role of Cannabinoids and Endocannabinoids in Cerebral Ischemia
Current Pharmaceutical Design Neuronal Death in Amyotrophic Lateral Sclerosis (ALS): What Can We Learn from Genetics?
CNS & Neurological Disorders - Drug Targets Release of Adenosine and ATP During Ischemia and Epilepsy
Current Neuropharmacology [General Articles] Cannabinoids: Mechanisms and Therapeutic Applications in the CNS
Current Medicinal Chemistry Metabotropic Glutamate Receptors: A Review on Prospectives and Therapeutic Aspects
Mini-Reviews in Medicinal Chemistry Stem Cell Based Therapy for Skeletal Muscle Diseases
Current Stem Cell Research & Therapy Mannitol Reduces Spinal Cord Edema in Rats with Acute Traumatic Spinal Cord Injury
Letters in Drug Design & Discovery Motor Recovery after Chronic Spinal Cord Transection in Rats: A Proof-of-Concept Study Evaluating a Combined Strategy
CNS & Neurological Disorders - Drug Targets Insight into Drug Design and Development of Anti-inflammatory Agents
Clinical Anti-Inflammatory & Anti-Allergy Drugs (Discontinued) The ERK 1 and 2 Pathway in the Nervous System: From Basic Aspects to Possible Clinical Applications in Pain and Visceral Dysfunction
Current Neuropharmacology Stem Cell Patents: An Innovative Approach to Anti-Cancer Drug Discovery
Recent Patents on Anti-Cancer Drug Discovery Adeno-Associated Virus (AAV) Vectors in the CNS
Current Gene Therapy PDZ Domain-mediated Protein Interactions: Therapeutic Targets in Neurological Disorders
Current Medicinal Chemistry