Current Pharmaceutical Biotechnology

Editor-in-Chief:

Davide Prosperi
Department of Biotechnology and Bioscience
University of Milan Bicocca
Milano
Italy

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Open Access Articles

Development of MTL-CEBPA: Small Activating RNA Drug for Hepatocellular Carcinoma open Access plus

Volume: 19  
Pp: 1-11
Ryan L. Setten, Helen L. Lightfoot, Nagy A. Habib and John J. Rossi*
DOI:10.2174/1389201019666180611093428

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Effect of Thermal and Shear Stressors on the Physical Properties, Structural Integrity and Biological Activity of the Anti-TNF-alpha Monoclonal Antibody, Infliximab open Access plus

Volume: 17   Issue: 10
Pp: 905-914
Jihad A. Alsaddique, Ritesh M. Pabari and Zebunnissa Ramtoola
DOI:10.2174/1389201017666160519111815

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Therapeutic Boosting of the Immune Response: Turning to CD14 for Help open Access plus

Volume: 17   Issue: 5
Pp: 414-418
Anne-Catherine Raby and Mario O. Labéta
DOI:10.2174/1389201017666160114095708

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Beta Cell Formation in vivo Through Cellular Networking, Integration and Processing (CNIP) in Wild Type Adult Mice open Access plus

Volume: 17   Issue: 4
Pp: 376-388
Bruno Doiron, Wenchao Hu and Ralph A DeFronzo
DOI:10.2174/1389201017666151223124031

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Small Amine Molecules: Solvent Design Toward Facile Improvement of Protein Stability Against Aggregation and Inactivation open Access plus

Volume: 17   Issue: 2
Pp: 116-125
Kentaro Shiraki, Shunsuke Tomita and Naoto Inoue
DOI:10.2174/1389201017666151029110229

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Global Cell Proteome Profiling, Phospho-signaling and Quantitative Proteomics for Identification of New Biomarkers in Acute Myeloid Leukemia Patients open Access plus

Volume: 17   Issue: 1
Pp: 52-70
Elise Aasebø, Rakel B. Forthun, Frode Berven, Frode Selheim and Maria Hernandez-Valladares
DOI:10.2174/1389201016666150826115626

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Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells open Access plus

Volume: 16   Issue: 9
Pp: 782-792
Pier M. Biava, Silvia Canaider, Federica Facchin, Eva Bianconi, Liza Ljungberg, Domenico Rotilio, Fabio Burigana and Carlo Ventura
DOI:10.2174/1389201016666150629102825

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Scalable Downstream Strategies for Purification of Recombinant Adeno- Associated Virus Vectors in Light of the Properties open Access plus

Volume: 16   Issue: 8
Pp: 684-695
Weihong Qu, Mingxi Wang, Yaqing Wu and Ruian Xu
DOI:10.2174/1389201016666150505122228

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Emulsomes Meet S-layer Proteins: An Emerging Targeted Drug Delivery System open Access plus

Volume: 16   Issue: 4
Pp: 392-405
Mehmet H. Ucisik, Uwe B. Sleytr and Bernhard Schuster
DOI:10.2174/138920101604150218112656

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Effect of Six Insecticides on Three Populations of Bactrocera (Tetradacus) minax (Diptera: Tephritidae) open Access plus

Volume: 16   Issue: 1
Pp: 77-83
Haoqiang Liu, Gaofei Jiang, Yunfei Zhang, Fei Chen, Xiaojiao Li, Jiansu Yue, Chun Ran and Zhimo Zhao
DOI:10.2174/138920101601150105105751

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TNF Binding Protein of Variola Virus Acts as a TNF Antagonist at Epicutaneous Application open Access plus

Volume: 16   Issue: 1
Pp: 72-76
Irina P. Gileva, Elena A. Viazovaia, Ludmila B. Toporkova, Dondok D. Tsyrendorzhiev, Sergei N. Shchelkunov and Irina A. Orlovskaya
DOI:10.2174/1389201015666141126114945

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Isolation of Achyrobichalcone from Achyrocline satureioides by High- Speed Countercurrent Chromatography open Access plus

Volume: 16   Issue: 1
Pp: 66-71
Juliana P. Carini, Gilda G. Leitao, Paulo H. Schneider, Cristiane C. Santos, Fernanda N. Costa, Maribete H. Holzschuh, Fabio Klamt and Valquiria L. Bassani
DOI:10.2174/1389201015666141110143019

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Vildagliptin Induces β-Cell Neogenesis and Improves the Lipid Profile in a Later Phase of Type 1 Diabetes open Access plus

Volume: 16   Issue: 1
Pp: 60-65
Pedro H. de Amorim Miranda, Otavio M. Monteiro, Joamyr V. Rossoni, Marcelo E. Silva, Wanderson G. de Lima and Daniela C. Costa
DOI:10.2174/1389201015666141113124341

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Physical Activity Interferes with the Immunomodulatory Effect of the Antineoplastic Drug NSC631570 open Access plus

Volume: 16   Issue: 1
Pp: 49-59
Larysa M. Skivka, Olexander G. Fedorchuk, Yaroslav M. Susak, Mychailo Y. Susak, Oksana M. Malanchuk, Mariia P. Rudyk and Yaroslav. W. Nowicky
DOI:10.2174/1389201015666141113125358

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Role of MicroRNA 21 in Mesenchymal Stem Cell (MSC) Differentiation: A Powerful Biomarker in MSCs Derived Cells open Access plus

Volume: 16   Issue: 1
Pp: 43-48
Durairaj Sekar, Subramanian Saravanan, Kulandaivelu Karikalan, Krishnaraj Thirugnanasambantham, Perumal Lalitha and Villianur I.H. Islam
DOI:10.2174/138920101601150105100851

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By Passing Microbial Resistance: Xylitol Controls Microorganisms Growth by Means of Its Anti-Adherence Property open Access plus

Volume: 16   Issue: 1
Pp: 35-42
Aline S. Ferreira, Annelisa F. Silva-Paes-Leme, Nádia R.B. Raposo and Sílvio S. da Silva
DOI:10.2174/1389201015666141202104347

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Nicotinic Acid Regulates Glucose and Lipid Metabolism Through Lipidindependent Pathways open Access plus

Volume: 16   Issue: 1
Pp: 3-10
Dongwu Liu, Xiaoqian Wang, Ling Kong and Zhiwei Chen
DOI:10.2174/1389201015666141126123401

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A Review on Response of Immune System in Spinal Cord Injury and Therapeutic Agents useful in Treatment open Access plus

Volume: 16   Issue: 1
Pp: 26-34
Narayanan Kasinathan, Meenashi B. Vanathi, Volety M. Subrahmanyam and Josyula V. Rao
DOI:10.2174/1389201015666141031121338

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Fragment-Based Drug Discovery and Molecular Docking in Drug Design open Access plus

Volume: 16   Issue: 1
Pp: 11-25
Tao Wang, Mian-Bin Wu, Zheng-Jie Chen, Hua Chen, Jian-Ping Lin and Li-Rong Yang
DOI:10.2174/1389201015666141122204532

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Individual Macromolecule Motion in a Crowded Living Cell open Access plus

Volume: 16   Issue: 1
Pp: 1-2
Zeno Foldes-Papp
DOI:10.2174/1389201016666141229103953

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Editorial (Thematic Issue: Molecular Image-Guided Cancer Treatment: Moving Towards Personalized Medicine-Part II) open Access plus

Volume: 14   Issue: 8
Pp: 713-713
Zhaofei Liu
DOI:10.2174/138920101408140122151945

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Measurements of Single Molecules in Solution and Live Cells Over Longer Observation Times Than Those Currently Possible: The Meaningful Time open Access plus

Volume: 14   Issue: 4
Pp: 441-444
Zeno Foldes-Papp
DOI:10.2174/1389201011314040009

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CNTO 530 Increases Expression of HbA and HbF in Murine Models of β-Thalassemia and Sickle Cell Anemia open Access plus

Volume: 14   Issue: 2
Pp: 242-248
Dorie A. Makropoulos, Ram Achuthanandam, Justin Avery, Krista Wilson, Kerry Brosnan, Andrew Miller, Thomas Nesspor, Denise Chroscinski, Mindi Walker, Devon Egenolf, ChiChi Huang and Peter J. Bugelski
DOI:10.2174/1389201011314020015

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Legalon® SIL: The Antidote of Choice in Patients with Acute Hepatotoxicity from Amatoxin Poisoning open Access plus

Volume: 13   Issue: 10
Pp: 1964-1970
Ulrich Mengs, Ralf - Torsten Pohl and Todd Mitchell
DOI:10.2174/138920112802273353

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Treatment of MDR1 Mutant Dogs with Macrocyclic Lactones open Access plus

Volume: 13   Issue: 6
Pp: 969-986
Joachim Geyer and Christina Janko
DOI:10.2174/138920112800399301

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A Review on the Toxicity and Non-Target Effects of Macrocyclic Lactones in Terrestrial and Aquatic Environments open Access plus

Volume: 13   Issue: 6
Pp: 1004-1060
Jean-Pierre Lumaret, Faiek Errouissi, Kevin Floate, Jorg Rombke and Keith Wardhaugh
DOI:10.2174/138920112800399257

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Antibody Targeting of TGF-β in Cancer Patients open Access plus

Volume: 12   Issue: 12
Pp: 2176-2189
Scott Lonning, Joan Mannick and John M. McPherson
DOI:10.2174/138920111798808392

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Metastasis: Recent Discoveries and Novel Perioperative Treatment Strategies with Particular Interest in the Hemostatic Compound Desmopressin open Access plus

Volume: 12   Issue: 11
Pp: 1974-1980
D. F. Alonso, G. V. Ripoll, J. Garona, N. B. Iannucci and D. E. Gomez
DOI:10.2174/138920111798377076

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Fluorescence Molecule Counting for Single-Molecule Studies in Crowded Environment of Living Cells without and with Broken Ergodicity open Access plus

Volume: 12   Issue: 5
Pp: 824-833
Zeno Foldes-Papp and Gerd Baumann
DOI:10.2174/138920111795470949

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Engineering of Therapeutic Proteins Production in Escherichia coli open Access plus

Volume: 12   Issue: 2
Pp: 268-274
Mariusz Kamionka
DOI:10.2174/138920111794295693

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Confocal Fluctuation Spectroscopy and Imaging open Access plus

Volume: 11   Issue: 6
Pp: 639-653
Zeno Foldes-Papp, Shih-Chu Jeff Liao, Tiefeng You, Ewald Terpetschnig and Beniamino Barbieri
DOI:10.2174/138920110792246618

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Meaningful Interpretation of Subdiffusive Measurements in Living Cells (Crowded Environment) by Fluorescence Fluctuation Microscopy open Access plus

Volume: 11   Issue: 5
Pp: 527-543
Gerd Baumann, Robert F. Place and Zeno Foldes-Papp
DOI:10.2174/138920110791591454

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Defining Features and Exploring Chemical Modifications to Manipulate RNAa Activity open Access plus

Volume: 11   Issue: 5
Pp: 518-526
Robert F. Place, Emily J. Noonan, Zeno Foldes-Papp and Long-Cheng Li
DOI:10.2174/138920110791591463

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Single-Molecule Fluorescence Studies of Nucleosome Dynamics open Access plus

Volume: 10   Issue: 5
Pp: 558-567
K. Gurunathan and M. Levitus
DOI:10.2174/138920109788922074

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Single-Quantum Dot Imaging with a Photon Counting Camera open Access plus

Volume: 10   Issue: 5
Pp: 543-557
X. Michalet, R. A. Colyer, J. Antelman, O. H.W. Siegmund, A. Tremsin, J. V. Vallerga and S. Weiss
DOI:10.2174/138920109788922100

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Reducing Background Contributions in Fluorescence Fluctuation Time- Traces for Single-Molecule Measurements in Solution open Access plus

Volume: 10   Issue: 5
Pp: 532-542
Zeno Foldes-Papp, Shih-Chu Jeff Liao, Tiefeng You and Beniamino Barbieri
DOI:10.2174/138920109788922137

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Single-Molecule Protein Interaction Conformational Dynamics open Access plus

Volume: 10   Issue: 5
Pp: 522-531
H. Peter Lu
DOI:10.2174/138920109788922119

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Design Considerations for Micro- and Nanopositioning: Leveraging the Latest for Biophysical Applications open Access plus

Volume: 10   Issue: 5
Pp: 515-521
S. C. Jordan and P. C. Anthony
DOI:10.2174/138920109788922173

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Membrane Deformation at Integrin Adhesions open Access plus

Volume: 10   Issue: 5
Pp: 508-514
Erdinc Atilgan and Ben Ovryn
DOI:10.2174/138920109788922146

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IOFF Generally Extends Fluorophore Longevity in the Presence of an Optical Trap open Access plus

Volume: 10   Issue: 5
Pp: 502-507
J. M. Ferrer, D. Fangyuan, R. R. Brau, P. B. Tarsa and M. J. Lang
DOI:10.2174/138920109788922182

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AFM Studies of λ Repressor Oligomers Securing DNA Loops open Access plus

Volume: 10   Issue: 5
Pp: 494-501
Haowei Wang, Laura Finzi, Dale E. A. Lewis and David Dunlap
DOI:10.2174/138920109788922155

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Effect of Antibiotics and Antimicrobial Peptides on Single Protein Motility open Access plus

Volume: 10   Issue: 5
Pp: 486-493
Tabita Winther and Lene B. Oddershede
DOI:10.2174/138920109788922083

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10 Years of Tension on Chromatin: Results from Single Molecule Force Spectroscopy open Access plus

Volume: 10   Issue: 5
Pp: 474-485
Fan-Tso Chien and John van Noort
DOI:10.2174/138920109788922128

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Single-Molecule Force Spectroscopy Using the NanoTracker Optical Tweezers Platform: from Design to Application open Access plus

Volume: 10   Issue: 5
Pp: 467-473
A. Wozniak, J. van Mameren and S. Ragona
DOI:10.2174/138920109788922164

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The Database dbEST Correctly Predicts Gene Expression in Colon Cancer Patients open Access plus

Volume: 9   Issue: 6
Pp: 510-515
M. Radeva, T. Hofmann, B. Altenberg, H. Mothes, K. K. Richter, B. Pool-Zobel and K. O. Greulich
DOI:10.2174/138920108786786330

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Monoclonal Antibodies as Innovative Therapeutics open Access plus

Volume: 9   Issue: 6
Pp: 423-430
Janice M. Reichert
DOI:10.2174/138920108786786358

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Ultra-Sensitive Fluorescence Reader for Bioanalysis open Access plus

Volume: 5   Issue: 3
Pp: 309-319
Jan Hesse, Max Sonnleitner and Gerhard J. Schutz
DOI:10.2174/1389201043376850

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Time-Resolved Confocal Fluorescence Imaging and Spectrocopy System with Single Molecule Sensitivity and Sub-Micrometer Resolution open Access plus

Volume: 5   Issue: 3
Pp: 299-308
M. Wahl, F. Koberling, M. Patting and Erdmann H. Rahn
DOI:10.2174/1389201043376841

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Using Photoinduced Charge Transfer Reactions to Study Conformational Dynamics of Biopolymers at the Single-Molecule Level open Access plus

Volume: 5   Issue: 3
Pp: 285-298
H. Neuweiler and M. Sauer
DOI:10.2174/1389201043376896

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Applications of Single-Molecule Detection to the Analysis of Pathogenic DNA open Access plus

Volume: 5   Issue: 3
Pp: 279-284
Oana Marina and Alonso Castro
DOI:10.2174/1389201043376823

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Single-Molecule Spectroscopy for Nucleic Acid Analysis: A New Approach for Disease Detection and Genomic Analysis open Access plus

Volume: 5   Issue: 3
Pp: 271-278
Peter M. Goodwin, Rhiannon L. Nolan and Hong Cai
DOI:10.2174/1389201043376814

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Single-Molecule Spectroscopy Studies of Conformational Change Dynamics in Enzymatic Reactions open Access plus

Volume: 5   Issue: 3
Pp: 261-269
H. Peter Lu
DOI:10.2174/1389201043376887

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Single Molecule Techniques for Biomedicine and Pharmacology open Access plus

Volume: 5   Issue: 3
Pp: 243-257
K. O. Greulic
DOI:10.2174/1389201043376878

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Parallel Confocal Detection of Single Biomolecules Using Diffractive Optics and Integrated Detector Units open Access plus

Volume: 5   Issue: 2
Pp: 231-241
H. Blom and M. Gosch
DOI:10.2174/1389201043377011

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Enzyme Assays for Confocal Single Molecule Spectroscopy open Access plus

Volume: 5   Issue: 2
Pp: 221-229
M. Jahnz and P. Schwille
DOI:10.2174/1389201043376922

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Analyzing for Co-Localization of Proteins at a Cell Membrane open Access plus

Volume: 5   Issue: 2
Pp: 213-220
Anja Nohe and Nils O. Petersen
DOI:10.2174/1389201043376931

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Ligand-Receptor Interactions in Live Cells by Fluorescence Correlation Spectroscopy open Access plus

Volume: 5   Issue: 2
Pp: 205-212
Aladdin Pramanik
DOI:10.2174/1389201043377002

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DNA Measurements by Using Fluorescence Correlation Spectroscopy and Two-Color Fluorescence Cross Correlation Spectroscopy open Access plus

Volume: 5   Issue: 2
Pp: 199-204
Takuya Takagi, Hiroaki Kii and Masataka Kinjo
DOI:10.2174/1389201043376904

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Direct Gene Expression Analysis open Access plus

Volume: 5   Issue: 2
Pp: 191-197
Holger Winter, Kerstin Korn and Rudolf Rigler
DOI:10.2174/1389201043376995

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Phenotypic Screening for Pharmaceuticals Using Tissue Constructs open Access plus

Volume: 5   Issue: 2
Pp: 181-189
T. Wakatsuki, J. A. Fee and E. L. Elson
DOI:10.2174/1389201043376940

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Towards Sorting of Biolibraries Using Single-Molecule Fluorescence Detection Techniques open Access plus

Volume: 5   Issue: 2
Pp: 173-179
Antonie J.W.G. Visser, Beno H. Kunst, Hans Keller and Arjen Schots
DOI:10.2174/1389201043376977

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Counting and Behavior of an Individual Fluorescent Molecule without Hydrodynamic Flow, Immobilization, or Photon Count Statistics open Access plus

Volume: 5   Issue: 2
Pp: 163-172
Zeno Foldes-Papp, Gerd Baumann, Ulrike Demel and Gernot P. Tilz
DOI:10.2174/1389201043376986

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Art and Artefacts of Fluorescence Correlation Spectroscopy open Access plus

Volume: 5   Issue: 2
Pp: 155-161
Jorg Enderlein, Ingo Gregor, Digambara Patra and Jorg Fitter
DOI:10.2174/1389201043377020

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The LSM 510 META - ConfoCor 2 System: An Integrated Imaging and Spectroscopic Platform for Single-Molecule Detection open Access plus

Volume: 5   Issue: 2
Pp: 135-154
Klaus Weisshart, Volker Jungel and Stephen J. Briddon
DOI:10.2174/1389201043376913

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Antibodies in Diagnostic Applications open Access plus

Volume: 5   Issue: 1
Pp: 9-16
Sergey Y. Tetin and Stephen D. Stroupe
DOI:10.2174/1389201043489602

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Clinical Applicability of Mass Spectrometry for Inhaled Carbon Compounds and the Characterization of Trace Element Patterns in Body Fluids open Access plus

Volume: 5   Issue: 1
Pp: 89-106
Wolfgang Domej, Zeno Foldes-Papp, Ulrike Demel and Gernot Peter Tilz
DOI:10.2174/1389201043489576

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Bioinformatics in Proteomics open Access plus

Volume: 5   Issue: 1
Pp: 79-88
Martin Blueggel, Daniel Chamrad and Helmut E. Meyer
DOI:10.2174/1389201043489648

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Tracking Cell Signaling Protein Expression and Phosphorylation by Innovative Proteomic Solutions open Access plus

Volume: 5   Issue: 1
Pp: 69-77
Steven Pelech
DOI:10.2174/1389201043489666

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Detection of Tumor Markers with ProteinChip® Technology open Access plus

Volume: 5   Issue: 1
Pp: 45-67
Andreas Wiesner
DOI:10.2174/1389201043489675

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From Production of Peptides in Milligram Amounts for Research to Multi-Tons Quantities for Drugs of the Future open Access plus

Volume: 5   Issue: 1
Pp: 29-43
Thomas Bruckdorfer, Oleg Marder and Fernando Albericio
DOI:10.2174/1389201043489620

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Combinatorial Protein Biochemistry for Therapeutics and Proteomics open Access plus

Volume: 5   Issue: 1
Pp: 17-27
David Lowe and Lutz Jermutus
DOI:10.2174/1389201043489585

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Optimal Enzymes for Single-Molecule Sequencing open Access plus

Volume: 5   Issue: 1
Pp: 119-126
Susanne Brakmann
DOI:10.2174/1389201043489611

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Moderate Hyperhomocysteinemia and Immune Activation open Access plus

Volume: 5   Issue: 1
Pp: 107-118
K. Schroecksnadel, B. Frick, B. Wirleitner, C. Winkler, H. Schennach and D. Fuchs
DOI:10.2174/1389201043489657

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Targeted Gene Silencing by Small Interfering RNA-Based Knock-Down Technology open Access plus

Volume: 5   Issue: 1
Pp: 1-7
Zhang J. and Hua Z.C.
DOI:10.2174/1389201043489558

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Foreword open Access plus

Volume: 4   Issue: 6
Pp: i-i
Jorg Enderlein, Jerker Widengren, Masataka Kinjo and Zeno Foldes-Papp
DOI:10.2174/1389201033377409

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High Fidelity SNP Genotyping Using Sequence-Specific Primer Elongation and Fluorescence Correlation Spectroscopy open Access plus

Volume: 4   Issue: 6
Pp: 477-484
K. Hori, W. S. Shin, C. Hemmi, T. Toyo-oka and T. Makino
DOI:10.2174/1389201033377391

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New Fluorescence Techniques for High-Throughput Drug Discovery open Access plus

Volume: 4   Issue: 6
Pp: 463-476
S. Jager, L. Brand and C. Eggeling
DOI:10.2174/1389201033377382

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Data Reduction Methods for Application of Fluorescence Correlation Spectroscopy to Pharmaceutical Drug Discovery open Access plus

Volume: 4   Issue: 6
Pp: 451-462
Lloyd M. Davis, Peter E. Williams, David A. Ball, Kerry M. Swift and Edmund D. Matayoshi
DOI:10.2174/1389201033377337

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Advances in Encoding of Colloids for Combinatorial Libraries: Applications in Genomics, Proteomics and Drug Discovery open Access plus

Volume: 4   Issue: 6
Pp: 439-449
Gwendolyn A. Lawrie, Bronwyn J. Battersby, Lisbeth Grondahl and Matt Trau
DOI:10.2174/1389201033377256