Current Pharmaceutical Biotechnology

Editor-in-Chief:

Davide Prosperi
Department of Biotechnology and Bioscience
University of Milan Bicocca
Milano
Italy

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Open Access Articles

Development of MTL-CEBPA: Small Activating RNA Drug for Hepatocellular Carcinoma open Access plus

Volume: 19   Issue: 8
Pp: 611-621
Ryan L. Setten, Helen L. Lightfoot, Nagy A. Habib and John J. Rossi*
DOI:10.2174/1389201019666180611093428

Therapeutic Potential of Small Activating RNAs (saRNAs) in Human Cancers open Access plus

Volume: 19   Issue: 8
Pp: 604-610
Sorah Yoon* and John J. Rossi*
DOI:10.2174/1389201019666180528084059

Verification between Original and Biosimilar Therapeutic Antibody Infliximab Using nSMOL Coupled LC-MS Bioanalysis in Human Serum open Access plus

Volume: 19   Issue: 6
Pp: 495-505
Noriko Iwamoto, Kotoko Yokoyama, Megumi Takanashi, Atsushi Yonezawa, Kazuo Matsubara and Takashi Shimada*
DOI:10.2174/1389201019666180703093517

Glutamatergic Deficits in Schizophrenia – Biomarkers and Pharmacological Interventions within the Ketamine Model open Access plus

Volume: 19   Issue: 4
Pp: 293-307
Moritz Haaf, Gregor Leicht, Stjepan Curic and Christoph Mulert*
DOI:10.2174/1389201019666180620112528

Collaboration of the Joint Research Centre and European Customs Laboratories for the Identification of New Psychoactive Substances open Access plus

Volume: 19   Issue: 2
Pp: 91-98
Claude Guillou*, Fabiano Reniero, Joana Lobo Vicente, Margaret Holland, Kamil Kolar, Hubert Chassaigne, Salvatore Tirendi and Herve Schepers
DOI:10.2174/1389201019666180523122717

Personalized Medicine and Adverse Drug Reactions: The Experience of An Italian Teaching Hospital open Access plus

Volume: 18   Issue: 3
Pp: 274-281
Raffaele La Russa, Vittorio Fineschi, Mariantonia Di Sanzo, Vittorio Gatto, Alessandro Santurro*, Gabriella Martini, Matteo Scopetti and Paola Frati
DOI:10.2174/1389201018666170207124835

Personalized Medicine Applied to Forensic Sciences: New Advances and Perspectives for a Tailored Forensic Approach open Access plus

Volume: 18   Issue: 3
Pp: 263-273
Alessandro Santurro, Anna Maria Vullo, Marina Borro, Giovanna Gentile, Raffaele La Russa, Maurizio Simmaco, Paola Frati* and Vittorio Fineschi
DOI:10.2174/1389201018666170207141525

Personalized Medicine in the Paediatric Population: The Balance Between Pharmacogenetic Progress and Bioethics open Access plus

Volume: 18   Issue: 3
Pp: 253-262
Stefania Schiavone, Margherita Neri, Cristoforo Pomara, Irene Riezzo, Luigia Trabace and Emanuela Turillazzi*
DOI:10.2174/1389201018666170207130236

Effect of Thermal and Shear Stressors on the Physical Properties, Structural Integrity and Biological Activity of the Anti-TNF-alpha Monoclonal Antibody, Infliximab open Access plus

Volume: 17   Issue: 10
Pp: 905-914
Jihad A. Alsaddique, Ritesh M. Pabari and Zebunnissa Ramtoola
DOI:10.2174/1389201017666160519111815

Therapeutic Boosting of the Immune Response: Turning to CD14 for Help open Access plus

Volume: 17   Issue: 5
Pp: 414-418
Anne-Catherine Raby and Mario O. Labéta
DOI:10.2174/1389201017666160114095708

Beta Cell Formation in vivo Through Cellular Networking, Integration and Processing (CNIP) in Wild Type Adult Mice open Access plus

Volume: 17   Issue: 4
Pp: 376-388
Bruno Doiron, Wenchao Hu and Ralph A DeFronzo
DOI:10.2174/1389201017666151223124031

Small Amine Molecules: Solvent Design Toward Facile Improvement of Protein Stability Against Aggregation and Inactivation open Access plus

Volume: 17   Issue: 2
Pp: 116-125
Kentaro Shiraki, Shunsuke Tomita and Naoto Inoue
DOI:10.2174/1389201017666151029110229

Global Cell Proteome Profiling, Phospho-signaling and Quantitative Proteomics for Identification of New Biomarkers in Acute Myeloid Leukemia Patients open Access plus

Volume: 17   Issue: 1
Pp: 52-70
Elise Aasebø, Rakel B. Forthun, Frode Berven, Frode Selheim and Maria Hernandez-Valladares
DOI:10.2174/1389201016666150826115626

Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells open Access plus

Volume: 16   Issue: 9
Pp: 782-792
Pier M. Biava, Silvia Canaider, Federica Facchin, Eva Bianconi, Liza Ljungberg, Domenico Rotilio, Fabio Burigana and Carlo Ventura
DOI:10.2174/1389201016666150629102825

Scalable Downstream Strategies for Purification of Recombinant Adeno- Associated Virus Vectors in Light of the Properties open Access plus

Volume: 16   Issue: 8
Pp: 684-695
Weihong Qu, Mingxi Wang, Yaqing Wu and Ruian Xu
DOI:10.2174/1389201016666150505122228

Emulsomes Meet S-layer Proteins: An Emerging Targeted Drug Delivery System open Access plus

Volume: 16   Issue: 4
Pp: 392-405
Mehmet H. Ucisik, Uwe B. Sleytr and Bernhard Schuster
DOI:10.2174/138920101604150218112656

Effect of Six Insecticides on Three Populations of Bactrocera (Tetradacus) minax (Diptera: Tephritidae) open Access plus

Volume: 16   Issue: 1
Pp: 77-83
Haoqiang Liu, Gaofei Jiang, Yunfei Zhang, Fei Chen, Xiaojiao Li, Jiansu Yue, Chun Ran and Zhimo Zhao
DOI:10.2174/138920101601150105105751

TNF Binding Protein of Variola Virus Acts as a TNF Antagonist at Epicutaneous Application open Access plus

Volume: 16   Issue: 1
Pp: 72-76
Irina P. Gileva, Elena A. Viazovaia, Ludmila B. Toporkova, Dondok D. Tsyrendorzhiev, Sergei N. Shchelkunov and Irina A. Orlovskaya
DOI:10.2174/1389201015666141126114945

Isolation of Achyrobichalcone from Achyrocline satureioides by High- Speed Countercurrent Chromatography open Access plus

Volume: 16   Issue: 1
Pp: 66-71
Juliana P. Carini, Gilda G. Leitao, Paulo H. Schneider, Cristiane C. Santos, Fernanda N. Costa, Maribete H. Holzschuh, Fabio Klamt and Valquiria L. Bassani
DOI:10.2174/1389201015666141110143019

Vildagliptin Induces β-Cell Neogenesis and Improves the Lipid Profile in a Later Phase of Type 1 Diabetes open Access plus

Volume: 16   Issue: 1
Pp: 60-65
Pedro H. de Amorim Miranda, Otavio M. Monteiro, Joamyr V. Rossoni, Marcelo E. Silva, Wanderson G. de Lima and Daniela C. Costa
DOI:10.2174/1389201015666141113124341

Physical Activity Interferes with the Immunomodulatory Effect of the Antineoplastic Drug NSC631570 open Access plus

Volume: 16   Issue: 1
Pp: 49-59
Larysa M. Skivka, Olexander G. Fedorchuk, Yaroslav M. Susak, Mychailo Y. Susak, Oksana M. Malanchuk, Mariia P. Rudyk and Yaroslav. W. Nowicky
DOI:10.2174/1389201015666141113125358

Role of MicroRNA 21 in Mesenchymal Stem Cell (MSC) Differentiation: A Powerful Biomarker in MSCs Derived Cells open Access plus

Volume: 16   Issue: 1
Pp: 43-48
Durairaj Sekar, Subramanian Saravanan, Kulandaivelu Karikalan, Krishnaraj Thirugnanasambantham, Perumal Lalitha and Villianur I.H. Islam
DOI:10.2174/138920101601150105100851

By Passing Microbial Resistance: Xylitol Controls Microorganisms Growth by Means of Its Anti-Adherence Property open Access plus

Volume: 16   Issue: 1
Pp: 35-42
Aline S. Ferreira, Annelisa F. Silva-Paes-Leme, Nádia R.B. Raposo and Sílvio S. da Silva
DOI:10.2174/1389201015666141202104347

Nicotinic Acid Regulates Glucose and Lipid Metabolism Through Lipidindependent Pathways open Access plus

Volume: 16   Issue: 1
Pp: 3-10
Dongwu Liu, Xiaoqian Wang, Ling Kong and Zhiwei Chen
DOI:10.2174/1389201015666141126123401

A Review on Response of Immune System in Spinal Cord Injury and Therapeutic Agents useful in Treatment open Access plus

Volume: 16   Issue: 1
Pp: 26-34
Narayanan Kasinathan, Meenashi B. Vanathi, Volety M. Subrahmanyam and Josyula V. Rao
DOI:10.2174/1389201015666141031121338

Fragment-Based Drug Discovery and Molecular Docking in Drug Design open Access plus

Volume: 16   Issue: 1
Pp: 11-25
Tao Wang, Mian-Bin Wu, Zheng-Jie Chen, Hua Chen, Jian-Ping Lin and Li-Rong Yang
DOI:10.2174/1389201015666141122204532

Individual Macromolecule Motion in a Crowded Living Cell open Access plus

Volume: 16   Issue: 1
Pp: 1-2
Zeno Foldes-Papp
DOI:10.2174/1389201016666141229103953

Editorial (Thematic Issue: Molecular Image-Guided Cancer Treatment: Moving Towards Personalized Medicine-Part II) open Access plus

Volume: 14   Issue: 8
Pp: 713-713
Zhaofei Liu
DOI:10.2174/138920101408140122151945

Measurements of Single Molecules in Solution and Live Cells Over Longer Observation Times Than Those Currently Possible: The Meaningful Time open Access plus

Volume: 14   Issue: 4
Pp: 441-444
Zeno Foldes-Papp
DOI:10.2174/1389201011314040009

CNTO 530 Increases Expression of HbA and HbF in Murine Models of β-Thalassemia and Sickle Cell Anemia open Access plus

Volume: 14   Issue: 2
Pp: 242-248
Dorie A. Makropoulos, Ram Achuthanandam, Justin Avery, Krista Wilson, Kerry Brosnan, Andrew Miller, Thomas Nesspor, Denise Chroscinski, Mindi Walker, Devon Egenolf, ChiChi Huang and Peter J. Bugelski
DOI:10.2174/1389201011314020015

Legalon® SIL: The Antidote of Choice in Patients with Acute Hepatotoxicity from Amatoxin Poisoning open Access plus

Volume: 13   Issue: 10
Pp: 1964-1970
Ulrich Mengs, Ralf - Torsten Pohl and Todd Mitchell
DOI:10.2174/138920112802273353

Treatment of MDR1 Mutant Dogs with Macrocyclic Lactones open Access plus

Volume: 13   Issue: 6
Pp: 969-986
Joachim Geyer and Christina Janko
DOI:10.2174/138920112800399301

A Review on the Toxicity and Non-Target Effects of Macrocyclic Lactones in Terrestrial and Aquatic Environments open Access plus

Volume: 13   Issue: 6
Pp: 1004-1060
Jean-Pierre Lumaret, Faiek Errouissi, Kevin Floate, Jorg Rombke and Keith Wardhaugh
DOI:10.2174/138920112800399257

Antibody Targeting of TGF-β in Cancer Patients open Access plus

Volume: 12   Issue: 12
Pp: 2176-2189
Scott Lonning, Joan Mannick and John M. McPherson
DOI:10.2174/138920111798808392

Metastasis: Recent Discoveries and Novel Perioperative Treatment Strategies with Particular Interest in the Hemostatic Compound Desmopressin open Access plus

Volume: 12   Issue: 11
Pp: 1974-1980
D. F. Alonso, G. V. Ripoll, J. Garona, N. B. Iannucci and D. E. Gomez
DOI:10.2174/138920111798377076

Fluorescence Molecule Counting for Single-Molecule Studies in Crowded Environment of Living Cells without and with Broken Ergodicity open Access plus

Volume: 12   Issue: 5
Pp: 824-833
Zeno Foldes-Papp and Gerd Baumann
DOI:10.2174/138920111795470949

Engineering of Therapeutic Proteins Production in Escherichia coli open Access plus

Volume: 12   Issue: 2
Pp: 268-274
Mariusz Kamionka
DOI:10.2174/138920111794295693

Confocal Fluctuation Spectroscopy and Imaging open Access plus

Volume: 11   Issue: 6
Pp: 639-653
Zeno Foldes-Papp, Shih-Chu Jeff Liao, Tiefeng You, Ewald Terpetschnig and Beniamino Barbieri
DOI:10.2174/138920110792246618

Meaningful Interpretation of Subdiffusive Measurements in Living Cells (Crowded Environment) by Fluorescence Fluctuation Microscopy open Access plus

Volume: 11   Issue: 5
Pp: 527-543
Gerd Baumann, Robert F. Place and Zeno Foldes-Papp
DOI:10.2174/138920110791591454

Defining Features and Exploring Chemical Modifications to Manipulate RNAa Activity open Access plus

Volume: 11   Issue: 5
Pp: 518-526
Robert F. Place, Emily J. Noonan, Zeno Foldes-Papp and Long-Cheng Li
DOI:10.2174/138920110791591463

Single-Molecule Fluorescence Studies of Nucleosome Dynamics open Access plus

Volume: 10   Issue: 5
Pp: 558-567
K. Gurunathan and M. Levitus
DOI:10.2174/138920109788922074

Single-Quantum Dot Imaging with a Photon Counting Camera open Access plus

Volume: 10   Issue: 5
Pp: 543-557
X. Michalet, R. A. Colyer, J. Antelman, O. H.W. Siegmund, A. Tremsin, J. V. Vallerga and S. Weiss
DOI:10.2174/138920109788922100

Reducing Background Contributions in Fluorescence Fluctuation Time- Traces for Single-Molecule Measurements in Solution open Access plus

Volume: 10   Issue: 5
Pp: 532-542
Zeno Foldes-Papp, Shih-Chu Jeff Liao, Tiefeng You and Beniamino Barbieri
DOI:10.2174/138920109788922137

Single-Molecule Protein Interaction Conformational Dynamics open Access plus

Volume: 10   Issue: 5
Pp: 522-531
H. Peter Lu
DOI:10.2174/138920109788922119

Design Considerations for Micro- and Nanopositioning: Leveraging the Latest for Biophysical Applications open Access plus

Volume: 10   Issue: 5
Pp: 515-521
S. C. Jordan and P. C. Anthony
DOI:10.2174/138920109788922173

Membrane Deformation at Integrin Adhesions open Access plus

Volume: 10   Issue: 5
Pp: 508-514
Erdinc Atilgan and Ben Ovryn
DOI:10.2174/138920109788922146

IOFF Generally Extends Fluorophore Longevity in the Presence of an Optical Trap open Access plus

Volume: 10   Issue: 5
Pp: 502-507
J. M. Ferrer, D. Fangyuan, R. R. Brau, P. B. Tarsa and M. J. Lang
DOI:10.2174/138920109788922182

AFM Studies of λ Repressor Oligomers Securing DNA Loops open Access plus

Volume: 10   Issue: 5
Pp: 494-501
Haowei Wang, Laura Finzi, Dale E. A. Lewis and David Dunlap
DOI:10.2174/138920109788922155

Effect of Antibiotics and Antimicrobial Peptides on Single Protein Motility open Access plus

Volume: 10   Issue: 5
Pp: 486-493
Tabita Winther and Lene B. Oddershede
DOI:10.2174/138920109788922083

10 Years of Tension on Chromatin: Results from Single Molecule Force Spectroscopy open Access plus

Volume: 10   Issue: 5
Pp: 474-485
Fan-Tso Chien and John van Noort
DOI:10.2174/138920109788922128

Single-Molecule Force Spectroscopy Using the NanoTracker Optical Tweezers Platform: from Design to Application open Access plus

Volume: 10   Issue: 5
Pp: 467-473
A. Wozniak, J. van Mameren and S. Ragona
DOI:10.2174/138920109788922164

The Database dbEST Correctly Predicts Gene Expression in Colon Cancer Patients open Access plus

Volume: 9   Issue: 6
Pp: 510-515
M. Radeva, T. Hofmann, B. Altenberg, H. Mothes, K. K. Richter, B. Pool-Zobel and K. O. Greulich
DOI:10.2174/138920108786786330

Monoclonal Antibodies as Innovative Therapeutics open Access plus

Volume: 9   Issue: 6
Pp: 423-430
Janice M. Reichert
DOI:10.2174/138920108786786358

How the Molecule Number Is Correctly Quantified in Two-Color Fluorescence Cross-Correlation Spectroscopy: Corrections for Cross-Talk and Quenching in Experiments open Access plus

Volume: 6   Issue: 6
Pp: 437-444
Zeno Foldes-Papp
DOI:10.2174/138920105775159296

Ultra-Sensitive Fluorescence Reader for Bioanalysis open Access plus

Volume: 5   Issue: 3
Pp: 309-319
Jan Hesse, Max Sonnleitner and Gerhard J. Schutz
DOI:10.2174/1389201043376850

Time-Resolved Confocal Fluorescence Imaging and Spectrocopy System with Single Molecule Sensitivity and Sub-Micrometer Resolution open Access plus

Volume: 5   Issue: 3
Pp: 299-308
M. Wahl, F. Koberling, M. Patting and Erdmann H. Rahn
DOI:10.2174/1389201043376841

Using Photoinduced Charge Transfer Reactions to Study Conformational Dynamics of Biopolymers at the Single-Molecule Level open Access plus

Volume: 5   Issue: 3
Pp: 285-298
H. Neuweiler and M. Sauer
DOI:10.2174/1389201043376896

Applications of Single-Molecule Detection to the Analysis of Pathogenic DNA open Access plus

Volume: 5   Issue: 3
Pp: 279-284
Oana Marina and Alonso Castro
DOI:10.2174/1389201043376823

Single-Molecule Spectroscopy for Nucleic Acid Analysis: A New Approach for Disease Detection and Genomic Analysis open Access plus

Volume: 5   Issue: 3
Pp: 271-278
Peter M. Goodwin, Rhiannon L. Nolan and Hong Cai
DOI:10.2174/1389201043376814

Single-Molecule Spectroscopy Studies of Conformational Change Dynamics in Enzymatic Reactions open Access plus

Volume: 5   Issue: 3
Pp: 261-269
H. Peter Lu
DOI:10.2174/1389201043376887

Single Molecule Techniques for Biomedicine and Pharmacology open Access plus

Volume: 5   Issue: 3
Pp: 243-257
K. O. Greulic
DOI:10.2174/1389201043376878

Parallel Confocal Detection of Single Biomolecules Using Diffractive Optics and Integrated Detector Units open Access plus

Volume: 5   Issue: 2
Pp: 231-241
H. Blom and M. Gosch
DOI:10.2174/1389201043377011

Enzyme Assays for Confocal Single Molecule Spectroscopy open Access plus

Volume: 5   Issue: 2
Pp: 221-229
M. Jahnz and P. Schwille
DOI:10.2174/1389201043376922

Analyzing for Co-Localization of Proteins at a Cell Membrane open Access plus

Volume: 5   Issue: 2
Pp: 213-220
Anja Nohe and Nils O. Petersen
DOI:10.2174/1389201043376931

Ligand-Receptor Interactions in Live Cells by Fluorescence Correlation Spectroscopy open Access plus

Volume: 5   Issue: 2
Pp: 205-212
Aladdin Pramanik
DOI:10.2174/1389201043377002

DNA Measurements by Using Fluorescence Correlation Spectroscopy and Two-Color Fluorescence Cross Correlation Spectroscopy open Access plus

Volume: 5   Issue: 2
Pp: 199-204
Takuya Takagi, Hiroaki Kii and Masataka Kinjo
DOI:10.2174/1389201043376904

Direct Gene Expression Analysis open Access plus

Volume: 5   Issue: 2
Pp: 191-197
Holger Winter, Kerstin Korn and Rudolf Rigler
DOI:10.2174/1389201043376995

Phenotypic Screening for Pharmaceuticals Using Tissue Constructs open Access plus

Volume: 5   Issue: 2
Pp: 181-189
T. Wakatsuki, J. A. Fee and E. L. Elson
DOI:10.2174/1389201043376940

Towards Sorting of Biolibraries Using Single-Molecule Fluorescence Detection Techniques open Access plus

Volume: 5   Issue: 2
Pp: 173-179
Antonie J.W.G. Visser, Beno H. Kunst, Hans Keller and Arjen Schots
DOI:10.2174/1389201043376977

Counting and Behavior of an Individual Fluorescent Molecule without Hydrodynamic Flow, Immobilization, or Photon Count Statistics open Access plus

Volume: 5   Issue: 2
Pp: 163-172
Zeno Foldes-Papp, Gerd Baumann, Ulrike Demel and Gernot P. Tilz
DOI:10.2174/1389201043376986

Art and Artefacts of Fluorescence Correlation Spectroscopy open Access plus

Volume: 5   Issue: 2
Pp: 155-161
Jorg Enderlein, Ingo Gregor, Digambara Patra and Jorg Fitter
DOI:10.2174/1389201043377020

The LSM 510 META - ConfoCor 2 System: An Integrated Imaging and Spectroscopic Platform for Single-Molecule Detection open Access plus

Volume: 5   Issue: 2
Pp: 135-154
Klaus Weisshart, Volker Jungel and Stephen J. Briddon
DOI:10.2174/1389201043376913

Antibodies in Diagnostic Applications open Access plus

Volume: 5   Issue: 1
Pp: 9-16
Sergey Y. Tetin and Stephen D. Stroupe
DOI:10.2174/1389201043489602

Clinical Applicability of Mass Spectrometry for Inhaled Carbon Compounds and the Characterization of Trace Element Patterns in Body Fluids open Access plus

Volume: 5   Issue: 1
Pp: 89-106
Wolfgang Domej, Zeno Foldes-Papp, Ulrike Demel and Gernot Peter Tilz
DOI:10.2174/1389201043489576

Bioinformatics in Proteomics open Access plus

Volume: 5   Issue: 1
Pp: 79-88
Martin Blueggel, Daniel Chamrad and Helmut E. Meyer
DOI:10.2174/1389201043489648

Tracking Cell Signaling Protein Expression and Phosphorylation by Innovative Proteomic Solutions open Access plus

Volume: 5   Issue: 1
Pp: 69-77
Steven Pelech
DOI:10.2174/1389201043489666

Detection of Tumor Markers with ProteinChip® Technology open Access plus

Volume: 5   Issue: 1
Pp: 45-67
Andreas Wiesner
DOI:10.2174/1389201043489675

From Production of Peptides in Milligram Amounts for Research to Multi-Tons Quantities for Drugs of the Future open Access plus

Volume: 5   Issue: 1
Pp: 29-43
Thomas Bruckdorfer, Oleg Marder and Fernando Albericio
DOI:10.2174/1389201043489620

Combinatorial Protein Biochemistry for Therapeutics and Proteomics open Access plus

Volume: 5   Issue: 1
Pp: 17-27
David Lowe and Lutz Jermutus
DOI:10.2174/1389201043489585

Optimal Enzymes for Single-Molecule Sequencing open Access plus

Volume: 5   Issue: 1
Pp: 119-126
Susanne Brakmann
DOI:10.2174/1389201043489611