Current Pharmaceutical Biotechnology

Editor-in-Chief:

Davide Prosperi
Department of Biotechnology and Bioscience
University of Milan Bicocca
Milano
Italy

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Editor's Choice

Downregulation of TdT Expression through Splicing Modulation by Antisense Peptide Nucleic Acid (PNA)

Volume: 20   Issue: 2
Pp: 168-178
Soheila Montazersaheb, Masoumeh Kazemi, Elahe Nabat, Peter E. Nielsen* and Mohammad S. Hejazi*
DOI: 10.2174/1389201020666190206202650

In vivo Evaluation and Alzheimer’s Disease Treatment Outcome of siRNA Loaded Dual Targeting Drug Delivery System

Volume: 20   Issue: 1
Pp: 56-62
Chi Zhang, Zhichun Gu, Long Shen, Xianyan Liu and Houwen Lin*
DOI: 10.2174/1389201020666190204141046

The Role of Extracellular Nucleic Acids in Rheumatoid Arthritis

Volume: 19   Issue: 15
Pp: 1182-1188
Elena Neumann*, Rebecca Hasseli, Uwe Lange and Ulf Müller-Ladner
DOI: 10.2174/1389201020666190102150216

Clinical Trials of Novel Targeted Therapies in Ovarian Cancer: Moving Beyond Poly ADP Ribose Polymerase (PARP) Inhibitors

Volume: 19   Issue: 14
Pp: 1114-1121
Quan Guo*, Qing Yang, Jun Li, Guipeng Liu, Igor Nikoulin and Steve Jia
DOI: 10.2174/1389201020666181226123054

Effect of Vinca Alkaloids on the Expression Levels of microRNAs Targeting Apoptosis-related Genes in Breast Cancer Cell Lines

Volume: 19   Issue: 13
Pp: 1076-1086
Adamantios V. Mavrogiannis, Ioanna Kokkinopoulou, Christos K. Kontos and Diamantis C. Sideris*
DOI: 10.2174/1389201019666181112103204

Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems

Volume: 19   Issue: 10
Pp: 764-770
Hiroshi Fujiwara*, Hisanori Matsumoto, Yukiyasu Sato, Akihito Horie, Masanori Ono, Mitsuhiro Nakamura, Yasunari Mizumoto, Kyosuke Kagami, Tomoko Fujiwara, Akira Hattori, Yoshiko Maida, Takiko Daikoku, Kazuhiko Imakawa and Yoshihiko Araki
DOI: 10.2174/1389201019666181029164906

Therapeutic Potential of Small Activating RNAs (saRNAs) in Human Cancers open access plus

Volume: 19   Issue: 8
Pp: 604-610
Sorah Yoon* and John J. Rossi*
DOI: 10.2174/1389201019666180528084059

Perspectives of Nanoemulsion Strategies in The Improvement of Oral, Parenteral and Transdermal Chemotherapy

Volume: 19   Issue: 4
Pp: 276-292
Manisha Pandey*, Hira Choudhury, Ong C. Yeun, Hoh M. Yin, Tan W. Lynn, Celine L.Y. Tine, Ng S. Wi, Kelly C.C. Yen, Cheng S. Phing, Prashant Kesharwani, Subrat K. Bhattamisra and Bapi Gorain*
DOI: 10.2174/1389201019666180605125234

Establishment of Novel Reporter Cells Stably Maintaining Transcription Factor-driven Human Secreted Alkaline Phosphatase Expression

Volume: 19   Issue: 3
Pp: 224-231
Riho Kurata, Asuka Kumagai, Xiaofeng Cui, Masamitsu Harada, Jun Nagai, Yasuhiro Yoshida, Kei-ichi Ozaki, Yoshimasa Tanaka and Tomo Yonezawa*
DOI: 10.2174/1389201019666180418093334

CAR T-cell Therapy: A New Era in Cancer Immunotherapy promotion: free to download

Volume: 19   Issue: 1
Pp: 5-18
Androulla N. Miliotou and Lefkothea C. Papadopoulou*
DOI: 10.2174/1389201019666180418095526

Derivation of Continuum Models from An Agent-based Cancer Model: Optimization and Sensitivity Analysis

Volume: 18   Issue: 15
Pp: 1249-1263
Dimitrios Voulgarelis*, Ajoy Velayudhan and Frank Smith
DOI: 10.2174/1389201019666180329111909

New Developments in CRISPR Technology: Improvements in Specificity and Efficiency

Volume: 18   Issue: 13
Pp: 1038-1054
Fatemeh Safari, Safar Farajnia*, Younes Ghasemi and Nosratollah Zarghami
DOI: 10.2174/1389201019666180209120533

Biologics in Inflammatory and Immunomediated Arthritis

Volume: 18   Issue: 12
Pp: 989-1007
Michele M. Luchetti*, Devis Benfaremo and Armando Gabrielli
DOI: 10.2174/1389201019666171226151852

Immunomodulatory Effects of Bifidobacterium longum W11 Produced Exopolysaccharide on Cytokine Production

Volume: 18   Issue: 11
Pp: 883-889
Rosanna Inturri*, Katia Mangano, Maria Santagati, Mariano Intrieri, Roberto Di Marco and Giovanna Blandino
DOI: 10.2174/1389201019666171226151551

Novel Insights into the Molecular Interaction of a Panduratin A Derivative with the Non Structural Protein (NS3) of Dengue Serotypes: A Molecular Dynamics Study

Volume: 18   Issue: 9
Pp: 769-782
Pratap Parida*, Raj Narain Singh Yadav, Budheswar Dehury, Debosree Ghosh, Namita Mahapatra, Analava Mitra and Tapan Kumar Mohanta*
DOI: 10.2174/1389201018666171122122338

Pharmaceutical Production of Anti-tumor and Immune-potentiating Enterococcus faecalis-2001 β-glucans: Enhanced Activity of Macrophage and Lymphocytes in Tumor-implanted Mice

Volume: 18   Issue: 8
Pp: 653-661
Yeun-Hwa Gu*, Hyunju Choi, Takenori Yamashita, Ki-Mun Kang, Masahiro Iwasa, Moon-Jo Lee, Kyoung Hae Lee and Cheorl-Ho Kim*
DOI: 10.2174/1389201018666171002130428

Ubiquitous Pharmacogenomics (U-PGx): The Time for Implementation is Now. An Horizon2020 Program to Drive Pharmacogenomics into Clinical Practice

Volume: 18   Issue: 3
Pp: 204-209
Erika Cecchin*, Rossana Roncato, Hendrik J. Guchelaar, Giuseppe Toffoli and for the Ubiquitous Pharmacogenomics Consortium
DOI: 10.2174/1389201018666170103103619

Pharmacogenomic Challenges in Cardiovascular Diseases: Examples of Drugs and Considerations for Future Integration in Clinical Practice

Volume: 18   Issue: 3
Pp: 231-241
Jerome Chatelin, Maria G. Stathopoulou, Alex-Ander A. Arguinano, Ting Xie and Sophie Visvikis-Siest*
DOI: 10.2174/1389201018666170123153626

Bone microRNAs and Ageing

Volume: 18   Issue: 3
Pp: 210-220
Tilen Kranjc, Barbara Ostanek and Janja Marc*
DOI: 10.2174/1389201018666170203091828

Personalized Medicine and Adverse Drug Reactions: The Experience of An Italian Teaching Hospital

Volume: 18   Issue: 3
Pp: 274-281
Raffaele La Russa, Vittorio Fineschi, Mariantonia Di Sanzo, Vittorio Gatto, Alessandro Santurro*, Gabriella Martini, Matteo Scopetti and Paola Frati
DOI: 10.2174/1389201018666170207124835

Personalized Medicine in the Paediatric Population: The Balance Between Pharmacogenetic Progress and Bioethics

Volume: 18   Issue: 3
Pp: 253-262
Stefania Schiavone, Margherita Neri, Cristoforo Pomara, Irene Riezzo, Luigia Trabace and Emanuela Turillazzi*
DOI: 10.2174/1389201018666170207130236

Personalized Medicine Applied to Forensic Sciences: New Advances and Perspectives for a Tailored Forensic Approach

Volume: 18   Issue: 3
Pp: 263-273
Alessandro Santurro, Anna Maria Vullo, Marina Borro, Giovanna Gentile, Raffaele La Russa, Maurizio Simmaco, Paola Frati* and Vittorio Fineschi
DOI: 10.2174/1389201018666170207141525

Personalised Healthcare: The DiMA Clinical Model

Volume: 18   Issue: 3
Pp: 242-252
Marina Borro, Giovanna Gentile, Luigi Cipolloni, Zeno Foldes-Papp, Paola Frati, Alessandro Santurro, Luana Lionetto and Maurizio Simmaco*
DOI: 10.2174/1389201018666170208125131

Personalized Medicine of Alcohol Addiction: Pharmacogenomics and Beyond

Volume: 18   Issue: 3
Pp: 221-230
Georgia Ragia and Vangelis G. Manolopoulos*
DOI: 10.2174/1389201018666170224105025

Clinical Applications of Personalized Medicine: A New Paradigm and Challenge

Volume: 18   Issue: 3
Pp: 194-203
Mariantonia Di Sanzo, Luigi Cipolloni, Marina Borro, Raffaele La Russa, Alessandro Santurro, Matteo Scopetti, Maurizio Simmaco and Paola Frati
DOI: 10.2174/1389201018666170224105600

Lipid-based siRNA Delivery Systems: Challenges, Promises and Solutions Along the Long Journey

Volume: 17   Issue: 8
Pp: 728-740
Can Sarisozen, Giuseppina Salzano and Vladimir P. Torchilin
DOI: 10.2174/1389201017666160401145319

Individual Macromolecule Motion in a Crowded Living Cell open access plus

Volume: 16   Issue: 1
Pp: 1-2
Zeno Foldes-Papp
DOI: 10.2174/1389201016666141229103953

Measurements of Single Molecules in Solution and Live Cells Over Longer Observation Times Than Those Currently Possible: The Meaningful Time open access plus

Volume: 14   Issue: 4
Pp: 441-444
Zeno Foldes-Papp
DOI: 10.2174/1389201011314040009

Fluorescence Molecule Counting for Single-Molecule Studies in Crowded Environment of Living Cells without and with Broken Ergodicity open access plus

Volume: 12   Issue: 5
Pp: 824-833
Zeno Foldes-Papp and Gerd Baumann
DOI: 10.2174/138920111795470949

Confocal Fluctuation Spectroscopy and Imaging open access plus

Volume: 11   Issue: 6
Pp: 639-653
Zeno Foldes-Papp, Shih-Chu Jeff Liao, Tiefeng You, Ewald Terpetschnig and Beniamino Barbieri
DOI: 10.2174/138920110792246618

Meaningful Interpretation of Subdiffusive Measurements in Living Cells (Crowded Environment) by Fluorescence Fluctuation Microscopy open access plus

Volume: 11   Issue: 5
Pp: 527-543
Gerd Baumann, Robert F. Place and Zeno Foldes-Papp
DOI: 10.2174/138920110791591454

Editorial [Hot Topic: Getting High on Single Molecule Biophysics (Guest Editor: Steven M. Block )] promotion: free to download

Volume: 10   Issue: 5
Pp: 464-466
Steven M. Block
DOI: 10.2174/138920109788922092

Single-Molecule Force Spectroscopy Using the NanoTracker Optical Tweezers Platform: from Design to Application open access plus

Volume: 10   Issue: 5
Pp: 467-473
A. Wozniak, J. van Mameren and S. Ragona
DOI: 10.2174/138920109788922164

10 Years of Tension on Chromatin: Results from Single Molecule Force Spectroscopy open access plus

Volume: 10   Issue: 5
Pp: 474-485
Fan-Tso Chien and John van Noort
DOI: 10.2174/138920109788922128

Effect of Antibiotics and Antimicrobial Peptides on Single Protein Motility open access plus

Volume: 10   Issue: 5
Pp: 486-493
Tabita Winther and Lene B. Oddershede
DOI: 10.2174/138920109788922083

AFM Studies of λ Repressor Oligomers Securing DNA Loops open access plus

Volume: 10   Issue: 5
Pp: 494-501
Haowei Wang, Laura Finzi, Dale E. A. Lewis and David Dunlap
DOI: 10.2174/138920109788922155

IOFF Generally Extends Fluorophore Longevity in the Presence of an Optical Trap open access plus

Volume: 10   Issue: 5
Pp: 502-507
J. M. Ferrer, D. Fangyuan, R. R. Brau, P. B. Tarsa and M. J. Lang
DOI: 10.2174/138920109788922182

Membrane Deformation at Integrin Adhesions open access plus

Volume: 10   Issue: 5
Pp: 508-514
Erdinc Atilgan and Ben Ovryn
DOI: 10.2174/138920109788922146

Design Considerations for Micro- and Nanopositioning: Leveraging the Latest for Biophysical Applications open access plus

Volume: 10   Issue: 5
Pp: 515-521
S. C. Jordan and P. C. Anthony
DOI: 10.2174/138920109788922173

Single-Molecule Protein Interaction Conformational Dynamics open access plus

Volume: 10   Issue: 5
Pp: 522-531
H. Peter Lu
DOI: 10.2174/138920109788922119

Reducing Background Contributions in Fluorescence Fluctuation Time- Traces for Single-Molecule Measurements in Solution open access plus

Volume: 10   Issue: 5
Pp: 532-542
Zeno Foldes-Papp, Shih-Chu Jeff Liao, Tiefeng You and Beniamino Barbieri
DOI: 10.2174/138920109788922137

Single-Quantum Dot Imaging with a Photon Counting Camera open access plus

Volume: 10   Issue: 5
Pp: 543-557
X. Michalet, R. A. Colyer, J. Antelman, O. H.W. Siegmund, A. Tremsin, J. V. Vallerga and S. Weiss
DOI: 10.2174/138920109788922100

Single-Molecule Fluorescence Studies of Nucleosome Dynamics open access plus

Volume: 10   Issue: 5
Pp: 558-567
K. Gurunathan and M. Levitus
DOI: 10.2174/138920109788922074

How the Molecule Number Is Correctly Quantified in Two-Color Fluorescence Cross-Correlation Spectroscopy: Corrections for Cross-Talk and Quenching in Experiments open access plus

Volume: 6   Issue: 6
Pp: 437-444
Zeno Foldes-Papp
DOI: 10.2174/138920105775159296

Single Molecule Techniques for Biomedicine and Pharmacology open access plus

Volume: 5   Issue: 3
Pp: 243-257
K. O. Greulic
DOI: 10.2174/1389201043376878

Single-Molecule Spectroscopy Studies of Conformational Change Dynamics in Enzymatic Reactions open access plus

Volume: 5   Issue: 3
Pp: 261-269
H. Peter Lu
DOI: 10.2174/1389201043376887

Single-Molecule Spectroscopy for Nucleic Acid Analysis: A New Approach for Disease Detection and Genomic Analysis open access plus

Volume: 5   Issue: 3
Pp: 271-278
Peter M. Goodwin, Rhiannon L. Nolan and Hong Cai
DOI: 10.2174/1389201043376814

Applications of Single-Molecule Detection to the Analysis of Pathogenic DNA open access plus

Volume: 5   Issue: 3
Pp: 279-284
Oana Marina and Alonso Castro
DOI: 10.2174/1389201043376823

Using Photoinduced Charge Transfer Reactions to Study Conformational Dynamics of Biopolymers at the Single-Molecule Level open access plus

Volume: 5   Issue: 3
Pp: 285-298
H. Neuweiler and M. Sauer
DOI: 10.2174/1389201043376896

Time-Resolved Confocal Fluorescence Imaging and Spectrocopy System with Single Molecule Sensitivity and Sub-Micrometer Resolution open access plus

Volume: 5   Issue: 3
Pp: 299-308
M. Wahl, F. Koberling, M. Patting and Erdmann H. Rahn
DOI: 10.2174/1389201043376841

Ultra-Sensitive Fluorescence Reader for Bioanalysis open access plus

Volume: 5   Issue: 3
Pp: 309-319
Jan Hesse, Max Sonnleitner and Gerhard J. Schutz
DOI: 10.2174/1389201043376850

The LSM 510 META - ConfoCor 2 System: An Integrated Imaging and Spectroscopic Platform for Single-Molecule Detection open access plus

Volume: 5   Issue: 2
Pp: 135-154
Klaus Weisshart, Volker Jungel and Stephen J. Briddon
DOI: 10.2174/1389201043376913

Art and Artefacts of Fluorescence Correlation Spectroscopy open access plus

Volume: 5   Issue: 2
Pp: 155-161
Jorg Enderlein, Ingo Gregor, Digambara Patra and Jorg Fitter
DOI: 10.2174/1389201043377020

Counting and Behavior of an Individual Fluorescent Molecule without Hydrodynamic Flow, Immobilization, or Photon Count Statistics open access plus

Volume: 5   Issue: 2
Pp: 163-172
Zeno Foldes-Papp, Gerd Baumann, Ulrike Demel and Gernot P. Tilz
DOI: 10.2174/1389201043376986

Towards Sorting of Biolibraries Using Single-Molecule Fluorescence Detection Techniques open access plus

Volume: 5   Issue: 2
Pp: 173-179
Antonie J.W.G. Visser, Beno H. Kunst, Hans Keller and Arjen Schots
DOI: 10.2174/1389201043376977

Phenotypic Screening for Pharmaceuticals Using Tissue Constructs open access plus

Volume: 5   Issue: 2
Pp: 181-189
T. Wakatsuki, J. A. Fee and E. L. Elson
DOI: 10.2174/1389201043376940

Direct Gene Expression Analysis open access plus

Volume: 5   Issue: 2
Pp: 191-197
Holger Winter, Kerstin Korn and Rudolf Rigler
DOI: 10.2174/1389201043376995

DNA Measurements by Using Fluorescence Correlation Spectroscopy and Two-Color Fluorescence Cross Correlation Spectroscopy open access plus

Volume: 5   Issue: 2
Pp: 199-204
Takuya Takagi, Hiroaki Kii and Masataka Kinjo
DOI: 10.2174/1389201043376904

Ligand-Receptor Interactions in Live Cells by Fluorescence Correlation Spectroscopy open access plus

Volume: 5   Issue: 2
Pp: 205-212
Aladdin Pramanik
DOI: 10.2174/1389201043377002

Analyzing for Co-Localization of Proteins at a Cell Membrane open access plus

Volume: 5   Issue: 2
Pp: 213-220
Anja Nohe and Nils O. Petersen
DOI: 10.2174/1389201043376931

Enzyme Assays for Confocal Single Molecule Spectroscopy open access plus

Volume: 5   Issue: 2
Pp: 221-229
M. Jahnz and P. Schwille
DOI: 10.2174/1389201043376922

Parallel Confocal Detection of Single Biomolecules Using Diffractive Optics and Integrated Detector Units open access plus

Volume: 5   Issue: 2
Pp: 231-241
H. Blom and M. Gosch
DOI: 10.2174/1389201043377011

Targeted Gene Silencing by Small Interfering RNA-Based Knock-Down Technology open access plus

Volume: 5   Issue: 1
Pp: 1-7
Zhang J. and Hua Z.C.
DOI: 10.2174/1389201043489558

Antibodies in Diagnostic Applications open access plus

Volume: 5   Issue: 1
Pp: 9-16
Sergey Y. Tetin and Stephen D. Stroupe
DOI: 10.2174/1389201043489602

Combinatorial Protein Biochemistry for Therapeutics and Proteomics open access plus

Volume: 5   Issue: 1
Pp: 17-27
David Lowe and Lutz Jermutus
DOI: 10.2174/1389201043489585