Current Pharmaceutical Design

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Open Access Articles

Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach open Access plus

Volume: 24   Issue:
Pp: 1-11
Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*
DOI:10.2174/1381612824666171201115126

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2-Hydroxypropyl-β-cyclodextrins and the Blood-Brain Barrier: Considerations for Niemann-Pick Disease Type C1 open Access plus

Volume: 23   Issue: 40
Pp: 6231-6238
Pericles Calias*
DOI:10.2174/1381612823666171019164220

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IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development open Access plus

Volume: 23   Issue: 38
Pp: 5964-5970
Ann Hellström*, David Ley, Boubou Hallberg, Chatarina Löfqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard
DOI:10.2174/1381612823666171002114545

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A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension open Access plus

Volume: 23   Issue: 34
Pp: 5191-5199
Louise M. Sorensen, Markus Wehland, Marcus Kruger, Ulf Simonsen, Mohamed Z. Nassef, Manfred Infanger and Daniela Grimm*
DOI:10.2174/1381612823666170908114227

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Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress open Access plus

Volume: 23   Issue: 27
Pp: 4066-4075
Akinori Yanaka*
DOI:10.2174/1381612823666170207103943

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Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates open Access plus

Volume: 23   Issue: 15
Pp: 2276-2286
Ulviye Acar Cevik, Begum Nurpelin Saglik, Yusuf Ozkay*, Zerrin Canturk, Juan Bueno, Fatih Demirci and Ali Savas Koparal
DOI:10.2174/1381612822666161201150131

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Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin open Access plus

Volume: 23   Issue: 14
Pp: 2131-2138
Xinya Hemu and James P. Tam*
DOI:10.2174/1381612822666161027120518

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Anti-EGFRvIII Chimeric Antigen Receptor-Modified T Cells for Adoptive Cell Therapy of Glioblastoma open Access plus

Volume: 23   Issue: 14
Pp: 2113-2116
Pei-pei Ren, Ming Li, Tian-fang Li and Shuang-yin Han*
DOI:10.2174/1381612823666170316125402

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Neural Circuits Underlying Fly Larval Locomotion open Access plus

Volume: 23   Issue: 12
Pp: 1722-1733
Hiroshi Kohsaka*, Pierre A. Guertin and Akinao Nose
DOI:10.2174/1381612822666161208120835

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Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases open Access plus

Volume: 23   Issue: 7
Pp: 1077-1097
Lili Wang, Rufeng Ma, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Shuzhen Guo, Minke Tang, Yu Li, Jianzhao Niu, Min Fu, Sihua Gao* and Dongwei Zhang*
DOI:10.2174/1381612822666161010105242

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Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity open Access plus

Volume: 23   Issue:
Pp: 1-19
Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macêdo
DOI:10.2174/1381612823666170711112510

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Polypharmacology in Precision Oncology: Current Applications and Future Prospects open Access plus

Volume: 22   Issue: 46
Pp: 6935-6945
Albert A. Antolin, Paul Workman, Jordi Mestres and Bissan Al-Lazikani
DOI:10.2174/1381612822666160923115828

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From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine open Access plus

Volume: 22   Issue: 46
Pp: 6903-6910
Cesar Pichardo-Almarza and Vanessa Diaz-Zuccarini
DOI:10.2174/1381612822666160905095402

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Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans open Access plus

Volume: 22   Issue: 44
Pp: 6701-6715
Mauro Serafini and Ilaria Peluso
DOI:10.2174/1381612823666161123094235

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Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored? open Access plus

Volume: 22   Issue: 40
Pp: 6107-6121
John Slattery, Derrick F. MacFabe, Stephen G. Kahler and Richard E. Frye
DOI:10.2174/1381612822666160905123953

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Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier open Access plus

Volume: 22   Issue: 35
Pp: 5463-5476
Nathalie Strazielle and Jean-François Ghersi-Egea
DOI:10.2174/1381612822666160726112115

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The Microbial Quality Aspects and Decontamination Approaches for the Herbal Medicinal Plants and Products: An in-Depth Review open Access plus

Volume: 22   Issue: 27
Pp: 4264-4287
Daniela Dal Molim Ghisleni, Marina de Souza Braga, Irene Satiko Kikuchi, Mirela Braşoveanu, Monica R. Nemţanu, Kamal Dua and Terezinha de Jesus Andreoli Pinto
DOI:10.2174/1381612822666160623070829

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AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species open Access plus

Volume: 22   Issue: 26
Pp: 3950-3970
Francesco Simone Ruggeri, Johnny Habchi, Andrea Cerreta and Giovanni Dietler
DOI:10.2174/1381612822666160518141911

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Miscellaneous Topics in Computer-Aided Drug Design: Synthetic Accessibility and GPU Computing, and Other Topics open Access plus

Volume: 22   Issue: 23
Pp: 3555-3568
Yoshifumi Fukunishi, Tadaaki Mashimo, Kiyotaka Misoo, Yoshinori Wakabayashi, Toshiaki Miyaki, Seiji Ohta, Mayu Nakamura and Kazuyoshi Ikeda
DOI:10.2174/1381612822666160414142547

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Therapeutic Targets for Management of Periodontitis and Diabetes open Access plus

Volume: 22   Issue: 15
Pp: 2216-2237
Corneliu Sima and Thomas E. Van Dyke
DOI:10.2174/1381612822666160216150338

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The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory open Access plus

Volume: 22   Issue: 12
Pp: 1756-1766
Mohammed I. Khan, Anna A. Sobocińska, Anna M. Czarnecka, Magdalena Król, Bruno Botta and Cezary Szczylik
DOI:10.2174/1381612822666151211094901

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Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier open Access plus

Volume: 22   Issue: 9
Pp: 1177-1193
David S. Hersh, Aniket S. Wadajkar, Nathan B. Roberts, Jimena G. Perez, Nina P. Connolly, Victor Frenkel, Jeffrey A. Winkles, Graeme F. Woodworth and Anthony J. Kim
DOI:10.2174/1381612822666151221150733

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Recent advances in the fundamental understanding of adhesive mixtures for inhalation open Access plus

Volume: 21   Issue: 40
Pp: 5900-5914
Floris Grasmeijer, Niels Grasmeijer, Paul Hagedoorn, Henderik Willem Frijlink and Anne Haaije de Boer
DOI:10.2174/1381612821666151008124622

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Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker open Access plus

Volume: 21   Issue: 26
Pp: 3797-3806
Kenji Hashimoto
DOI:10.2174/1381612821666150605111345

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Lipid-Based Nanocarriers for RNA Delivery open Access plus

Volume: 21   Issue: 22
Pp: 3140-3147
Hui Yi Xue, Pengbo Guo, Wu-Cheng Wen and Ho Lun Wong
DOI:10.2174/1381612821666150531164540

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Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations open Access plus

Volume: 21   Issue: 19
Pp: 2677-2694
Daryl R. Williams
DOI:10.2174/1381612821666150416100319

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Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus open Access plus

Volume: 21   Issue: 16
Pp: 2054-2057
Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi, Daniel R Knight, Carlo Viti, Graziella Orefici, Jose-Luis Martinez, Ana Teresa Freitas, Teresa M. Coque, Ian Morrissey and behalf of the BIOHYPO consortium
DOI:10.2174/1381612821666150310103238

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Macrophages in Immunopathology of Atherosclerosis: A Target for Diagnostics and Therapy open Access plus

Volume: 21   Issue: 9
Pp: 1172-1179
Alexander N. Orekhov, Igor A. Sobenin, Mikhail A. Gavrilin, Alexei Gratchev, Svetlana Y. Kotyashova, Nikita G. Nikiforov and Julia Kzhyshkowska
DOI:10.2174/1381612820666141013120459

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Assessment and Relevance of Carotid Intima-Media Thickness (C-IMT) in Primary and Secondary Cardiovascular Prevention open Access plus

Volume: 21   Issue: 9
Pp: 1164-1171
Alessio Ravani, Jose Pablo Werba, Beatrice Frigerio, Daniela Sansaro, Mauro Amato, Elena Tremoli and Damiano Baldassarre
DOI:10.2174/1381612820666141013121545

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Antihypertensive Drugs Metabolism: An Update to Pharmacokinetic Profiles and Computational Approaches open Access plus

Volume: 21   Issue: 6
Pp: 806-822
Aikaterini Zisaki, Ljubisa Miskovic and Vassily Hatzimanikatis
DOI:10.2174/1381612820666141024151119

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Targeting Cardiomyocyte Ca2+ Homeostasis in Heart Failure open Access plus

Volume: 21   Issue: 4
Pp: 431-448
Asmund T. Roe, Michael Frisk and William E. Louch
DOI:10.2174/138161282104141204124129

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Biomarkers Predicting a Need for Intensive Treatment in Patients with Early Arthritis open Access plus

Volume: 21   Issue: 2
Pp: 170-181
I. Gonzalez-Alvaro, A.M. Ortiz, I.V. Seoane, R. Garcia-Vicuna, C. Martinez and R.P. Gomariz
DOI:10.2174/1381612820666140825123104

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Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy open Access plus

Volume: 20   Issue: 42
Pp: 6584-6643
Roger Gilabert-Oriol, Alexander Weng, Benedicta von Mallinckrodt, Matthias F. Melzig, Hendrik Fuchs and Mayank Thakur
DOI:10.2174/1381612820666140826153913

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Tankyrases: Structure, Function and Therapeutic Implications in Cancer open Access plus

Volume: 20   Issue: 41
Pp: 6472-6488
Teemu Haikarainen, Stefan Krauss and Lari Lehtio
DOI:10.2174/1381612820666140630101525

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Telomere Maintenance Mechanisms in Cancer: Clinical Implications open Access plus

Volume: 20   Issue: 41
Pp: 6361-6374
Roger R. Reddel
DOI:10.2174/1381612820666140630101047

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Mechanisms of Action of Anesthetics for the Modulation of Perioperative Thrombosis: Evidence for Immune Mechanisms from Basic and Clinical Studies open Access plus

Volume: 20   Issue: 36
Pp: 5779-5793
Toshiharu Azma, Florin Tuluc, Taishin Ito, Chikako Aoyama-Mani, Shinji Kawahito and Hiroyuki Kinoshita
DOI:10.2174/1381612820666140204102044

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Brain Innate Immunity in the Regulation of Neuroinflammation: Therapeutic Strategies by Modulating CD200-CD200R Interaction Involve the Cannabinoid System open Access plus

Volume: 20   Issue: 29
Pp: 4707-4722
Miriam Hernangomez, Francisco J. Carrillo-Salinas, Miriam Mecha, Fernando Correa, Leyre Mestre, Frida Loria, Ana Feliu, Fabian Docagne and Carmen Guaza
DOI:10.2174/1381612820666140130202911

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Dipeptidyl-peptidase 4 Inhibition: Linking Metabolic Control to Cardiovascular Protection open Access plus

Volume: 20   Issue: 14
Pp: 2387-2394
Angelo Avogaro, Saula de Kreutzenberg and Gianpaolo Fadini
DOI:10.2174/13816128113199990474

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Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings open Access plus

Volume: 20   Issue: 13
Pp: 2126-2137
Johannes Wrege, Andre Schmidt, Anna Walter, Renata Smieskova, Kerstin Bendfeldt, Ernst-Wilhelm Radue, Undine E. Lang and Stefan Borgwardt
DOI:10.2174/13816128113199990428

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New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis Treatment using VEGF Receptor Antibodies and Celecoxib open Access plus

Volume: 20   Issue: 7
Pp: 1097-1103
Masahiko Nakamura, Tetsufumi Takahashi, Hidenori Matsui, Shinichi Takahashi, Somay Y. Murayama, Hidekazu Suzuki and Kanji Tsuchimoto
DOI:10.2174/13816128113199990420

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Network Pharmacology Strategies Toward Multi-Target Anticancer Therapies: From Computational Models to Experimental Design Principles open Access plus

Volume: 20   Issue: 1
Pp: 23-36
Jing Tang and Tero Aittokallio
DOI:10.2174/13816128113199990470

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The µ Opioid Receptor and Ligands Acting at the µ Opioid Receptor, as Therapeutics and Potential Therapeutics open Access plus

Volume: 19   Issue: 42
Pp: 7415-7434
Mariana Spetea, Muhammad Faheem Asim, Gerhard Wolber and Helmut Schmidhammer
DOI:10.2174/13816128113199990362

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Functionalization of the Carbonyl Group in Position 6 of Morphinan-6-ones. Development of Novel 6-Amino and 6-Guanidino Substituted 14-Alkoxymorphinans open Access plus

Volume: 19   Issue: 42
Pp: 7391-7399
Helmut Schmidhammer, Mariana Spetea, Petra Windisch, Johannes Schütz, Pal Riba, Mahmoud Al-Khrasani and Susanna Furst
DOI:10.2174/138161281942140105164804

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Smart Stimuli Sensitive Nanogels in Cancer Drug Delivery and Imaging: A Review open Access plus

Volume: 19   Issue: 41
Pp: 7203-7218
S. Maya, Bruno Sarmento, Amrita Nair, N. Sanoj Rejinold, Shantikumar V. Nair and R. Jayakumar
DOI:10.2174/138161281941131219124142

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Mechanisms of Drug Resistance in Cancer Chemotherapy: Coordinated Role and Regulation of Efflux Transporters and Metabolizing Enzymes open Access plus

Volume: 19   Issue: 40
Pp: 7126-7140
Ramya Krishna Vadlapatla, Aswani Dutt Vadlapudi, Dhananjay Pal and Ashim K. Mitra
DOI:10.2174/13816128113199990493

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The Cellular Autophagy Markers Beclin-1 and LC3B-II are Increased During Reperfusion in Fibrillated Mouse Hearts open Access plus

Volume: 19   Issue: 39
Pp: 6912-6918
Gregory Meyer, Attila Czompa, Cyril Reboul, Evelin Csepanyi, Andras Czegledi, Istvan Bak, Gyorgy Balla, Jozsef Balla, Arpad Tosaki and Istvan Lekli
DOI:10.2174/138161281939131127122510

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Cardioprotective Effects of Sour Cherry Seed Extract (SCSE) on the Hypercholesterolemic Rabbit Heart open Access plus

Volume: 19   Issue: 39
Pp: 6896-6905
Bela Juhasz, Attila Kertész, Jozsef Balla, Gyorgy Balla, Zoltán Szabo, Mariann Bombicz, Daniel Priksz, Rudolf Gesztelyi, Balazs Varga, David D. Haines and Arpad Tosaki
DOI:10.2174/138161281939131127120517

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The STAT3 Inhibitor Stattic Impairs Cardiomyocyte Mitochondrial Function Through Increased Reactive Oxygen Species Formation open Access plus

Volume: 19   Issue: 39
Pp: 6890-6895
Kerstin Boengler, Elvira Ungefug, Gerd Heusch and Rainer Schulz
DOI:10.2174/138161281939131127115940

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Ghrelin as a Neuroprotective and Palliative Agent in Alzheimer's and Parkinson's Disease open Access plus

Volume: 19   Issue: 38
Pp: 6773-6790
Vanessa V. dos Santos, Ana Lúcia S. Rodrigues, Thereza C. De Lima, Susana R. de Barioglio, Rita Raisman-Vozari and Rui D. Prediger
DOI:10.2174/13816128113199990411

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Iron Oxide Nanoparticle-induced Oxidative Stress and Genotoxicity in Human Skin Epithelial and Lung Epithelial Cell Lines open Access plus

Volume: 19   Issue: 37
Pp: 6681-6690
Maqusood Ahamed, Hisham A. Alhadlaq, Javed Alam, M. A. Majeed Khan, Daoud Ali and Saud Alarafi
DOI:10.2174/1381612811319370011

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Nanomaterials for Photohyperthermia: A Review open Access plus

Volume: 19   Issue: 37
Pp: 6622-6634
Jonathan Fang and Yu-Chie Chen
DOI:10.2174/1381612811319370006

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Recent Advances in Superparamagnetic Iron Oxide Nanoparticles for Cellular Imaging and Targeted Therapy Research open Access plus

Volume: 19   Issue: 37
Pp: 6575-6593
Yi-Xiang J. Wang, Shouhu Xuan, Marc Port and Jean-Marc Idee
DOI:10.2174/1381612811319370003

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Immunization Against Active Ghrelin Using Virus-Like Particles for Obesity Treatment open Access plus

Volume: 19   Issue: 36
Pp: 6551-6558
Sara Andrade, Filipa Pinho, Andreia M. Ribeiro, Marcos Carreira, Felipe F. Casanueva, Polly Roy and Mariana P. Monteiro
DOI:10.2174/13816128113199990506

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Diffusion Tensor Imaging to Determine Effects of Antidementive Treatment on Cerebral Structural Connectivity in Alzheimer’s Disease open Access plus

Volume: 19   Issue: 36
Pp: 6416-6425
Ingo Kilimann, Yuttachai Likitjaroen, Harald Hampel and Stefan Teipel
DOI:10.2174/1381612811319360003

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Anti-miRNA-23a Oligonucleotide Suppresses Glioma Cells Growth by Targeting Apoptotic Protease Activating Factor-1 open Access plus

Volume: 19   Issue: 35
Pp: 6382-6389
Shizhong Lian, Ruyi Shi, Tao Bai, Yang Liu, Wang Miao, Hongqin Wang, Xiaodong Liu and Yimin Fan
DOI:10.2174/13816128113199990509

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Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases open Access plus

Volume: 19   Issue: 35
Pp: 6375-6381
Toru Ishibashi
DOI:10.2174/13816128113199990507

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The Smart Targeting of Nanoparticles open Access plus

Volume: 19   Issue: 35
Pp: 6315-6329
Adam D. Friedman, Sarah E. Claypool and Rihe Liu
DOI:10.2174/13816128113199990375

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Nanostructed Cubosomes as Advanced Drug Delivery System open Access plus

Volume: 19   Issue: 35
Pp: 6290-6297
Xin Pan, Ke Han, Xinsheng Peng, Zhiwen Yang, Lingzhen Qin, Chune Zhu, Xintian Huang, Xuan Shi, Linghui Dian, Ming Lu and Chuanbin Wu
DOI:10.2174/1381612811319350006

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Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence open Access plus

Volume: 19   Issue: 34
Pp: 6064-6093
Joao Tomé-Carneiro, Mar Larrosa, Antonio González-Sarrías, Francisco A. Tomás-Barberán, María Teresa García-Conesa and Juan Carlos Espín
DOI:10.2174/13816128113199990407

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Mitochondrial Mutations in Atherosclerosis: New Solutions in Research and Possible Clinical Applications open Access plus

Volume: 19   Issue: 33
Pp: 5942-5953
Igor A. Sobenin, Dimitry A. Chistiakov, Yuri V. Bobryshev, Anton Y. Postnov and Alexander N. Orekhov
DOI:10.2174/1381612811319330013

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Role of Adiponectin in the Metabolic Syndrome: Current Perspectives on its Modulation as a Treatment Strategy open Access plus

Volume: 19   Issue: 32
Pp: 5755-5763
Indira Padmalayam and Mark Suto
DOI:10.2174/13816128113199990360

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Hyperglycemia-induced Oxidative Stress and its Role in Diabetes Mellitus Related Cardiovascular Diseases open Access plus

Volume: 19   Issue: 32
Pp: 5695-5703
Teresa Vanessa Fiorentino, Annamaria Prioletta, Pengou Zuo and Franco Folli
DOI:10.2174/1381612811319320005

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N-Glycosylation of Plant-produced Recombinant Proteins open Access plus

Volume: 19   Issue: 31
Pp: 5503-5512
Dirk Bosch, Alexandra Castilho, Andreas Loos, Arjen Schots and Herta Steinkellner
DOI:10.2174/1381612811319310006

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Commercial Aspects of Pharmaceutical Protein Production in Plants open Access plus

Volume: 19   Issue: 31
Pp: 5471-5477
Rainer Fischer, Stefan Schillberg, Johannes F. Buyel and Richard M. Twyman
DOI:10.2174/1381612811319310002

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The Culture-Repopulating Ability Assays and Incubation in Low Oxygen: A Simple Way to Test Drugs on Leukaemia Stem or Progenitor Cells open Access plus

Volume: 19   Issue: 30
Pp: 5374-5383
Maria Grazia Cipolleschi, Elisabetta Rovida and Persio Dello Sbarba
DOI:10.2174/1381612811319300006

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New Molecular Targets in the Treatment of NSCLC open Access plus

Volume: 19   Issue: 30
Pp: 5333-5343
Clorinda Schettino, Maria Anna Bareschino, Paola Claudia Sacco, Paolo Maione, Antonio Rossi, Francesca Casaluce, Assunta Sgambato and Cesare Gridelli
DOI:10.2174/13816128113199990343

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Genetic Predisposition in NAFLD and NASH: Impact on Severity of Liver Disease and Response to Treatment open Access plus

Volume: 19   Issue: 29
Pp: 5219-5238
Paola Dongiovanni, Quentin M. Anstee and Luca Valenti
DOI:10.2174/13816128113199990381

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Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD open Access plus

Volume: 19   Issue: 29
Pp: 5177-5192
Amedeo Lonardo, Silvia Sookoian, Michel Chonchol, Paola Loria and Giovanni Targher
DOI:10.2174/1381612811319290003

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Epidemiology and Natural History of Patients with NAFLD open Access plus

Volume: 19   Issue: 29
Pp: 5169-5176
Neeraj Bhala, Ramy Ibrahim Kamal Jouness and Elisabetta Bugianesi
DOI:10.2174/13816128113199990336

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