Current Pharmaceutical Design

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Open Access Articles

Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach open Access plus

Volume: 24   Issue: 13
Pp: 1366-1376
Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*
DOI:10.2174/1381612824666171201115126

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Development of Peptide Vaccines in Dengue open Access plus

Volume: 24   Issue: 11
Pp: 1157-1173
Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh*
DOI:10.2174/1381612823666170913163904

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Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems open Access plus

Volume: 24   Issue: 6
Pp: 710-717
Osamu Kanauchi*, Akira Andoh, Sazaly AbuBakar and Naoki Yamamoto
DOI:10.2174/1381612824666180116163411

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Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity open Access plus

Volume: 24   Issue: 5
Pp: 576-594
Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macedo
DOI:10.2174/1381612823666170711112510

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Safety Strategies of Genetically Engineered T Cells in Cancer Immunotherapy open Access plus

Volume: 24   Issue: 1
Pp: 78-83
Yan-Bei Ren, Shang-Jun Sun and Shuang-Yin Han*
DOI:10.2174/1381612824666171227222624

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Machine Learning-based Virtual Screening and Its Applications to Alzheimer’s Drug Discovery: A Review open Access plus

Volume: 24  
Pp: 1-12
Kristy A. Carpenter and Xudong Huang*
DOI:10.2174/1381612824666180607124038

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Defense Mechanisms Against Acid Exposure by Dental Enamel Formation, Saliva and Pancreatic Juice Production open Access plus

Volume: 24  
Pp: 1-11
Robert Racz, Akos Nagy, Zoltan Rakonczay , Erika Katalin Dunavari, Gabor Gerber and Gabor Varga*
DOI:10.2174/1381612824666180515125654

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Seizures and Antiepileptic Drugs: From Pathophysiology to Clinical Practice open Access plus

Volume: 23   Issue: 42
Pp: 6376-6388
Nihan Carcak and Cigdem Ozkara*
DOI:10.2174/1381612823666171115101557

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Pivotal Roles of Interleukin-17 as the Epicenter of Bone Loss Diseases open Access plus

Volume: 23   Issue: 41
Pp: 6302-6309
Chongshan Liao, Chengfei Zhang and Yanqi Yang*
DOI:10.2174/1381612823666170519120040

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2-Hydroxypropyl-β-cyclodextrins and the Blood-Brain Barrier: Considerations for Niemann-Pick Disease Type C1 open Access plus

Volume: 23   Issue: 40
Pp: 6231-6238
Pericles Calias*
DOI:10.2174/1381612823666171019164220

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IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development open Access plus

Volume: 23   Issue: 38
Pp: 5964-5970
Ann Hellstrom*, David Ley, Boubou Hallberg, Chatarina Lofqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard
DOI:10.2174/1381612823666171002114545

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A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension open Access plus

Volume: 23   Issue: 34
Pp: 5191-5199
Louise M. Sorensen, Markus Wehland, Marcus Kruger, Ulf Simonsen, Mohamed Z. Nassef, Manfred Infanger and Daniela Grimm*
DOI:10.2174/1381612823666170908114227

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A Review of Chinese Herbal Medicine for the Treatment of Chronic Heart Failure open Access plus

Volume: 23   Issue: 34
Pp: 5115-5124
Yong Wang*, Qiyan Wang, Chun Li, Linghui Lu, Qian Zhang, Ruixin Zhu* and Wei Wang*
DOI:10.2174/1381612823666170925163427

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Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer open Access plus

Volume: 23   Issue: 32
Pp: 4827-4841
Jack Tuszynski, Tatiana M. Tilli and Michael Levin*
DOI:10.2174/1381612823666170530105837

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DNA Base Excision Repair: The Achilles' Heel of Tumour Cells and their Microenvironment? open Access plus

Volume: 23   Issue: 32
Pp: 4758-4772
Mattia Poletto *, Arnaud J. Legrand * and Grigory L. Dianov*
DOI:10.2174/1381612823666170710123602

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Current Methods of the Circulating Tumor Cells (CTC) Analysis: A Brief Overview open Access plus

Volume: 23   Issue: 32
Pp: 4726-4728
Natalia Dementeva, Daria Kokova and Oleg A. Mayboroda*
DOI:10.2174/1381612823666170616082608

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Protein Kinase Inhibitors as Therapeutic Drugs in AML: Advances and Challenges open Access plus

Volume: 23   Issue: 29
Pp: 4303-4310
Yuan Ling, Zikang Zhang, Hua Zhang* and Zunnan Huang*
DOI:10.2174/1381612823666170703164114

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Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress open Access plus

Volume: 23   Issue: 27
Pp: 4066-4075
Akinori Yanaka*
DOI:10.2174/1381612823666170207103943

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Neuroprotection in Hypoxic-Ischemic Brain Injury Targeting Glial Cells open Access plus

Volume: 23   Issue: 26
Pp: 3899-3906
Maria Ines Herrera*, Sofia Mucci*, George E. Barreto, Rodolfo Kolliker-Frers and Francisco Capani*
DOI:10.2174/1381612823666170727145422

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Hydrogel-Based Cell Therapies for Kidney Regeneration: Current Trends in Biofabrication and In Vivo Repair open Access plus

Volume: 23   Issue: 26
Pp: 3845-3857
Katja Jansen*, Carl C.L. Schuurmans*, Jitske Jansen, Rosalinde Masereeuw* and Tina Vermonden*
DOI:10.2174/1381612823666170710155726

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Long-Circulating Liposomal Delivery System Targeting at PDGFR-β Enhances the Therapeutic Effect of IFN-α on Hepatic Fibrosis open Access plus

Volume: 23   Issue: 20
Pp: 3034-3046
Qinghua Li*, Qi Yu, Jing Ju, Tiangeng You*, Zhiqiang Yan, Xiangli Nan, Jie Zhong and Jing E. Zhou
DOI:10.2174/1381612822666161208144953

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Chemical Properties of Caffeic and Ferulic Acids in Biological System: Implications in Cancer Therapy. A Review open Access plus

Volume: 23   Issue: 20
Pp: 3015-3023
Sarah S. Damasceno*, Bruna B. Dantas, Jaime Ribeiro-Filho, Demetrius Antônio M. Araújo and José Galberto M. da Costa
DOI:10.2174/1381612822666161208145508

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Neuroprotective Effect of Atremorine in an Experimental Model of Parkinson’s Disease open Access plus

Volume: 23   Issue: 18
Pp: 2673-2684
Ivan Carrera*, Lucia Fernandez-Novoa, Carolina Sampedro and Ramon Cacabelos
DOI:10.2174/1381612823666170210143530

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Is Metformin a Perfect Drug? Updates in Pharmacokinetics and Pharmacodynamics open Access plus

Volume: 23   Issue: 17
Pp: 2532-2550
Magdalena Markowicz-Piasecka*, Kristiina M. Huttunen, Lukasz Mateusiak, Elzbieta Mikiciuk-Olasik and Joanna Sikora
DOI:10.2174/1381612822666161201152941

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Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates open Access plus

Volume: 23   Issue: 15
Pp: 2276-2286
Ulviye Acar Cevik, Begum Nurpelin Saglik, Yusuf Ozkay*, Zerrin Canturk, Juan Bueno, Fatih Demirci and Ali Savas Koparal
DOI:10.2174/1381612822666161201150131

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Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin open Access plus

Volume: 23   Issue: 14
Pp: 2131-2138
Xinya Hemu and James P. Tam*
DOI:10.2174/1381612822666161027120518

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Anti-EGFRvIII Chimeric Antigen Receptor-Modified T Cells for Adoptive Cell Therapy of Glioblastoma open Access plus

Volume: 23   Issue: 14
Pp: 2113-2116
Pei-pei Ren, Ming Li, Tian-fang Li and Shuang-yin Han*
DOI:10.2174/1381612823666170316125402

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Selective Inhibition of Phosphodiesterases 4A, B, C and D Isoforms in Chronic Respiratory Diseases: Current and Future Evidences open Access plus

Volume: 23   Issue: 14
Pp: 2073-2083
Sonia Contreras*, Javier Milara*, Esteban Morcillo and Julio Cortijo
DOI:10.2174/1381612823666170214105651

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Traumatic Brain Injury: Preclinical Imaging Diagnostic(s) and Therapeutic Approaches open Access plus

Volume: 23   Issue: 13
Pp: 1909-1915
Eric L. Kaijzel*, Ermond R. van Beek, Marieke A. Stammes, Ivo Que, Alan B. Chan, Clemens W.G.M. Lowik and Luis J. Cruz
DOI:10.2174/1381612823666170116141116

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PI3K/Akt Pathway: A Potential Therapeutic Target for Chronic Pain open Access plus

Volume: 23   Issue: 12
Pp: 1860-1868
Shu-Ping Chen, Ya-Qun Zhou, Dai-Qiang Liu, Wen Zhang, Anne Manyande, Xue-Hai Guan, Yu-ke Tian, Da-Wei Ye* and Deeq Mohamed Omar
DOI:10.2174/1381612823666170210150147

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Neural Circuits Underlying Fly Larval Locomotion open Access plus

Volume: 23   Issue: 12
Pp: 1722-1733
Hiroshi Kohsaka*, Pierre A. Guertin and Akinao Nose
DOI:10.2174/1381612822666161208120835

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Inflammation: A Novel Therapeutic Target/Direction in Atherosclerosis open Access plus

Volume: 23   Issue: 8
Pp: 1216-1227
Bin Li, Weihong Li, Xiaoli Li and Hong Zhou*
DOI:10.2174/1381612822666161230142931

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Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases open Access plus

Volume: 23   Issue: 7
Pp: 1077-1097
Lili Wang, Rufeng Ma, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Shuzhen Guo, Minke Tang, Yu Li, Jianzhao Niu, Min Fu, Sihua Gao* and Dongwei Zhang*
DOI:10.2174/1381612822666161010105242

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Polypharmacology in Precision Oncology: Current Applications and Future Prospects open Access plus

Volume: 22   Issue: 46
Pp: 6935-6945
Albert A. Antolin, Paul Workman, Jordi Mestres and Bissan Al-Lazikani
DOI:10.2174/1381612822666160923115828

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From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine open Access plus

Volume: 22   Issue: 46
Pp: 6903-6910
Cesar Pichardo-Almarza and Vanessa Diaz-Zuccarini
DOI:10.2174/1381612822666160905095402

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Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans open Access plus

Volume: 22   Issue: 44
Pp: 6701-6715
Mauro Serafini and Ilaria Peluso
DOI:10.2174/1381612823666161123094235

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Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored? open Access plus

Volume: 22   Issue: 40
Pp: 6107-6121
John Slattery, Derrick F. MacFabe, Stephen G. Kahler and Richard E. Frye
DOI:10.2174/1381612822666160905123953

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Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier open Access plus

Volume: 22   Issue: 35
Pp: 5463-5476
Nathalie Strazielle and Jean-François Ghersi-Egea
DOI:10.2174/1381612822666160726112115

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The Microbial Quality Aspects and Decontamination Approaches for the Herbal Medicinal Plants and Products: An in-Depth Review open Access plus

Volume: 22   Issue: 27
Pp: 4264-4287
Daniela Dal Molim Ghisleni, Marina de Souza Braga, Irene Satiko Kikuchi, Mirela Braşoveanu, Monica R. Nemţanu, Kamal Dua and Terezinha de Jesus Andreoli Pinto
DOI:10.2174/1381612822666160623070829

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AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species open Access plus

Volume: 22   Issue: 26
Pp: 3950-3970
Francesco Simone Ruggeri, Johnny Habchi, Andrea Cerreta and Giovanni Dietler
DOI:10.2174/1381612822666160518141911

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Miscellaneous Topics in Computer-Aided Drug Design: Synthetic Accessibility and GPU Computing, and Other Topics open Access plus

Volume: 22   Issue: 23
Pp: 3555-3568
Yoshifumi Fukunishi, Tadaaki Mashimo, Kiyotaka Misoo, Yoshinori Wakabayashi, Toshiaki Miyaki, Seiji Ohta, Mayu Nakamura and Kazuyoshi Ikeda
DOI:10.2174/1381612822666160414142547

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Therapeutic Targets for Management of Periodontitis and Diabetes open Access plus

Volume: 22   Issue: 15
Pp: 2216-2237
Corneliu Sima and Thomas E. Van Dyke
DOI:10.2174/1381612822666160216150338

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The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory open Access plus

Volume: 22   Issue: 12
Pp: 1756-1766
Mohammed I. Khan, Anna A. Sobocińska, Anna M. Czarnecka, Magdalena Król, Bruno Botta and Cezary Szczylik
DOI:10.2174/1381612822666151211094901

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Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier open Access plus

Volume: 22   Issue: 9
Pp: 1177-1193
David S. Hersh, Aniket S. Wadajkar, Nathan B. Roberts, Jimena G. Perez, Nina P. Connolly, Victor Frenkel, Jeffrey A. Winkles, Graeme F. Woodworth and Anthony J. Kim
DOI:10.2174/1381612822666151221150733

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Recent advances in the fundamental understanding of adhesive mixtures for inhalation open Access plus

Volume: 21   Issue: 40
Pp: 5900-5914
Floris Grasmeijer, Niels Grasmeijer, Paul Hagedoorn, Henderik Willem Frijlink and Anne Haaije de Boer
DOI:10.2174/1381612821666151008124622

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Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker open Access plus

Volume: 21   Issue: 26
Pp: 3797-3806
Kenji Hashimoto
DOI:10.2174/1381612821666150605111345

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Lipid-Based Nanocarriers for RNA Delivery open Access plus

Volume: 21   Issue: 22
Pp: 3140-3147
Hui Yi Xue, Pengbo Guo, Wu-Cheng Wen and Ho Lun Wong
DOI:10.2174/1381612821666150531164540

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Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations open Access plus

Volume: 21   Issue: 19
Pp: 2677-2694
Daryl R. Williams
DOI:10.2174/1381612821666150416100319

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Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus open Access plus

Volume: 21   Issue: 16
Pp: 2054-2057
Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi, Daniel R Knight, Carlo Viti, Graziella Orefici, Jose-Luis Martinez, Ana Teresa Freitas, Teresa M. Coque, Ian Morrissey and behalf of the BIOHYPO consortium
DOI:10.2174/1381612821666150310103238

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Macrophages in Immunopathology of Atherosclerosis: A Target for Diagnostics and Therapy open Access plus

Volume: 21   Issue: 9
Pp: 1172-1179
Alexander N. Orekhov, Igor A. Sobenin, Mikhail A. Gavrilin, Alexei Gratchev, Svetlana Y. Kotyashova, Nikita G. Nikiforov and Julia Kzhyshkowska
DOI:10.2174/1381612820666141013120459

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Assessment and Relevance of Carotid Intima-Media Thickness (C-IMT) in Primary and Secondary Cardiovascular Prevention open Access plus

Volume: 21   Issue: 9
Pp: 1164-1171
Alessio Ravani, Jose Pablo Werba, Beatrice Frigerio, Daniela Sansaro, Mauro Amato, Elena Tremoli and Damiano Baldassarre
DOI:10.2174/1381612820666141013121545

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Antihypertensive Drugs Metabolism: An Update to Pharmacokinetic Profiles and Computational Approaches open Access plus

Volume: 21   Issue: 6
Pp: 806-822
Aikaterini Zisaki, Ljubisa Miskovic and Vassily Hatzimanikatis
DOI:10.2174/1381612820666141024151119

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Targeting Cardiomyocyte Ca2+ Homeostasis in Heart Failure open Access plus

Volume: 21   Issue: 4
Pp: 431-448
Asmund T. Roe, Michael Frisk and William E. Louch
DOI:10.2174/138161282104141204124129

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Biomarkers Predicting a Need for Intensive Treatment in Patients with Early Arthritis open Access plus

Volume: 21   Issue: 2
Pp: 170-181
I. Gonzalez-Alvaro, A.M. Ortiz, I.V. Seoane, R. Garcia-Vicuna, C. Martinez and R.P. Gomariz
DOI:10.2174/1381612820666140825123104

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Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy open Access plus

Volume: 20   Issue: 42
Pp: 6584-6643
Roger Gilabert-Oriol, Alexander Weng, Benedicta von Mallinckrodt, Matthias F. Melzig, Hendrik Fuchs and Mayank Thakur
DOI:10.2174/1381612820666140826153913

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Tankyrases: Structure, Function and Therapeutic Implications in Cancer open Access plus

Volume: 20   Issue: 41
Pp: 6472-6488
Teemu Haikarainen, Stefan Krauss and Lari Lehtio
DOI:10.2174/1381612820666140630101525

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Telomere Maintenance Mechanisms in Cancer: Clinical Implications open Access plus

Volume: 20   Issue: 41
Pp: 6361-6374
Roger R. Reddel
DOI:10.2174/1381612820666140630101047

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Mechanisms of Action of Anesthetics for the Modulation of Perioperative Thrombosis: Evidence for Immune Mechanisms from Basic and Clinical Studies open Access plus

Volume: 20   Issue: 36
Pp: 5779-5793
Toshiharu Azma, Florin Tuluc, Taishin Ito, Chikako Aoyama-Mani, Shinji Kawahito and Hiroyuki Kinoshita
DOI:10.2174/1381612820666140204102044

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Brain Innate Immunity in the Regulation of Neuroinflammation: Therapeutic Strategies by Modulating CD200-CD200R Interaction Involve the Cannabinoid System open Access plus

Volume: 20   Issue: 29
Pp: 4707-4722
Miriam Hernangomez, Francisco J. Carrillo-Salinas, Miriam Mecha, Fernando Correa, Leyre Mestre, Frida Loria, Ana Feliu, Fabian Docagne and Carmen Guaza
DOI:10.2174/1381612820666140130202911

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Dipeptidyl-peptidase 4 Inhibition: Linking Metabolic Control to Cardiovascular Protection open Access plus

Volume: 20   Issue: 14
Pp: 2387-2394
Angelo Avogaro, Saula de Kreutzenberg and Gianpaolo Fadini
DOI:10.2174/13816128113199990474

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Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings open Access plus

Volume: 20   Issue: 13
Pp: 2126-2137
Johannes Wrege, Andre Schmidt, Anna Walter, Renata Smieskova, Kerstin Bendfeldt, Ernst-Wilhelm Radue, Undine E. Lang and Stefan Borgwardt
DOI:10.2174/13816128113199990428

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New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis Treatment using VEGF Receptor Antibodies and Celecoxib open Access plus

Volume: 20   Issue: 7
Pp: 1097-1103
Masahiko Nakamura, Tetsufumi Takahashi, Hidenori Matsui, Shinichi Takahashi, Somay Y. Murayama, Hidekazu Suzuki and Kanji Tsuchimoto
DOI:10.2174/13816128113199990420

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Network Pharmacology Strategies Toward Multi-Target Anticancer Therapies: From Computational Models to Experimental Design Principles open Access plus

Volume: 20   Issue: 1
Pp: 23-36
Jing Tang and Tero Aittokallio
DOI:10.2174/13816128113199990470

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The µ Opioid Receptor and Ligands Acting at the µ Opioid Receptor, as Therapeutics and Potential Therapeutics open Access plus

Volume: 19   Issue: 42
Pp: 7415-7434
Mariana Spetea, Muhammad Faheem Asim, Gerhard Wolber and Helmut Schmidhammer
DOI:10.2174/13816128113199990362

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Functionalization of the Carbonyl Group in Position 6 of Morphinan-6-ones. Development of Novel 6-Amino and 6-Guanidino Substituted 14-Alkoxymorphinans open Access plus

Volume: 19   Issue: 42
Pp: 7391-7399
Helmut Schmidhammer, Mariana Spetea, Petra Windisch, Johannes Schütz, Pal Riba, Mahmoud Al-Khrasani and Susanna Furst
DOI:10.2174/138161281942140105164804

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Smart Stimuli Sensitive Nanogels in Cancer Drug Delivery and Imaging: A Review open Access plus

Volume: 19   Issue: 41
Pp: 7203-7218
S. Maya, Bruno Sarmento, Amrita Nair, N. Sanoj Rejinold, Shantikumar V. Nair and R. Jayakumar
DOI:10.2174/138161281941131219124142

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Mechanisms of Drug Resistance in Cancer Chemotherapy: Coordinated Role and Regulation of Efflux Transporters and Metabolizing Enzymes open Access plus

Volume: 19   Issue: 40
Pp: 7126-7140
Ramya Krishna Vadlapatla, Aswani Dutt Vadlapudi, Dhananjay Pal and Ashim K. Mitra
DOI:10.2174/13816128113199990493

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The Cellular Autophagy Markers Beclin-1 and LC3B-II are Increased During Reperfusion in Fibrillated Mouse Hearts open Access plus

Volume: 19   Issue: 39
Pp: 6912-6918
Gregory Meyer, Attila Czompa, Cyril Reboul, Evelin Csepanyi, Andras Czegledi, Istvan Bak, Gyorgy Balla, Jozsef Balla, Arpad Tosaki and Istvan Lekli
DOI:10.2174/138161281939131127122510

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Cardioprotective Effects of Sour Cherry Seed Extract (SCSE) on the Hypercholesterolemic Rabbit Heart open Access plus

Volume: 19   Issue: 39
Pp: 6896-6905
Bela Juhasz, Attila Kertész, Jozsef Balla, Gyorgy Balla, Zoltán Szabo, Mariann Bombicz, Daniel Priksz, Rudolf Gesztelyi, Balazs Varga, David D. Haines and Arpad Tosaki
DOI:10.2174/138161281939131127120517

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The STAT3 Inhibitor Stattic Impairs Cardiomyocyte Mitochondrial Function Through Increased Reactive Oxygen Species Formation open Access plus

Volume: 19   Issue: 39
Pp: 6890-6895
Kerstin Boengler, Elvira Ungefug, Gerd Heusch and Rainer Schulz
DOI:10.2174/138161281939131127115940

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