Current Pharmaceutical Design


William A. Banks  
Seattle VA Puget Sound Health Care System
Room 810C, Building 1
1660 S. Columbian Way
Seattle, WA 98108


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Open Access Articles

Probucol-induced hERG Channel Reduction can be Rescued by Matrine and Oxymatrine in vitro open Access plus

Volume: 25   Issue: 43
Pp: 4606-4612
Yuan-Qi Shi, Pan Fan, Guo-Cui Zhang, Yu-Hao Zhang, Ming-Zhu Li, Fang Wang and Bao-Xin Li*

Nanomedicines to Treat Skin Pathologies with Natural Molecules open Access plus

Volume: 25   Issue: 21
Pp: 2323-2337
Elisabetta Esposito*, Claudio Nastruzzi, Maddalena Sguizzato and Rita Cortesi

The Role of Autophagy and Death Pathways in Dose-dependent Isoproterenolinduced Cardiotoxicity open Access plus

Volume: 25   Issue: 19
Pp: 2192-2198
Alexandra Gyongyosi, Rita Zilinyi, Andras Czegledi, Agnes Tosaki, Arpad Tosaki and Istvan Lekli*

Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway open Access plus

Volume: 25   Issue: 16
Pp: 1828-1846
Ana Paunkov, Dionysios V. Chartoumpekis, Panos G. Ziros, Niki Chondrogianni, Thomas W. Kensler and Gerasimos P. Sykiotis*

Treatment of Glucocorticoid-Induced Osteoporosis with Bisphosphonates Alone, Vitamin D Alone or a Combination Treatment in Eastern Asians: A Meta-Analysis open Access plus

Volume: 25   Issue: 14
Pp: 1653-1662
Junjie Wang and Hongzhuo Li*

Circulating Factors and Ultrasono-findings are Linked to Previous Atherosclerotic Burden and Recurrent Risk open Access plus

Volume: 25   Issue: 12
Pp: 1424-1429
Kyoung J. Cho, Jihye Kim, Soung H. Jeon and Gyung W. Kim*

Effects of As2O3 and Resveratrol on the Proliferation and Apoptosis of Colon Cancer Cells and the hERG-mediated Potential Mechanisms open Access plus

Volume: 25   Issue: 12
Pp: 1385-1391
Caichuan Yan*, Fengmei Li*, Yuhao Zhang, Yang Li, Mingzhu Li, Fang Wang, Guocui Zhang, Yuexin Li, Baoxin Li and Xin Zhao

Therapeutic Efficacy of Molecular Hydrogen: A New Mechanistic Insight open Access plus

Volume: 25   Issue: 9
Pp: 946-955
Toru Ishibashi*

Emerging Therapeutic Targets in Oncologic Photodynamic Therapy open Access plus

Volume: 24   Issue: 44
Pp: 5268-5295
Gina Manda*, Mihail E. Hinescu, Ionela V. Neagoe, Luis F.V. Ferreira, Rica Boscencu, Paul Vasos, Selma H. Basaga and Antonio Cuadrado

Role of Advanced Glycation End Products in Carcinogenesis and their Therapeutic Implications open Access plus

Volume: 24   Issue: 44
Pp: 5245-5251
David Schröter and Annika Höhn*

Dietary Approaches to Attain Fish Health with Special Reference to their Immune System open Access plus

Volume: 24   Issue: 41
Pp: 4921-4931
Thea Magrone*, Matteo A. Russo and Emilio Jirillo

Small Molecules as PD-1/PD-L1 Pathway Modulators for Cancer Immunotherapy open Access plus

Volume: 24   Issue: 41
Pp: 4911-4920
Peifu Jiao, Qiaohong Geng*, Peng Jin, Gaoxing Su, Houyun Teng, Jinlong Dong and Bing Yan*

Advantages of Vasoactive Intestinal Peptide for the Future Treatment of Parkinson’s Disease open Access plus

Volume: 24   Issue: 39
Pp: 4693-4701
Orhan Tansel Korkmaz and Neşe Tunçel*

Novel Data on the Prevalence, Identification, Scouting, and Treatment of Familial Hypercholesterolaemia open Access plus

Volume: 24   Issue: 31
Pp: 3597-3598
Michael Doumas, Konstantinos Imprialos, Konstantinos Stavropoulos and Vasilios G. Athyros

Machine Learning-based Virtual Screening and Its Applications to Alzheimer’s Drug Discovery: A Review open Access plus

Volume: 24   Issue: 28
Pp: 3347-3358
Kristy A. Carpenter and Xudong Huang*

Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis open Access plus

Volume: 24   Issue: 26
Pp: 3143-3151
Alexander N. Orekhov*, Yumiko Oishi , Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Igor A. Sobenin, Alexander Kel, Daria Stelmashenko, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth and Michael Bukrinsky

Novel Technologies for Dipeptide Drugs Design and their Implantation open Access plus

Volume: 24   Issue: 26
Pp: 3020-3027
Tatiana A. Gudasheva*, Rita U. Ostrovskaya and Sergey B. Seredenin

Coronary Microcirculation in Ischemic Heart Disease open Access plus

Volume: 24   Issue: 25
Pp: 2893-2899
Axel R. Pries*, Wolfgang M. Kuebler and Helmut Habazettl

Next-generation Metabolomics in the Development of New Antidepressants: Using Albiflorin as an Example open Access plus

Volume: 24   Issue: 22
Pp: 2530-2540
Jian Han, Yonghong Xia, Lejun Lin, Zuoguang Zhang, Hui Tian and Kefeng Li*

Role of Heme Oxygenases in Cardiovascular Syndromes and Co-morbidities open Access plus

Volume: 24   Issue: 20
Pp: 2322-2325
David D. Haines and Arpad Tosaki*

Defense Mechanisms Against Acid Exposure by Dental Enamel Formation, Saliva and Pancreatic Juice Production open Access plus

Volume: 24   Issue: 18
Pp: 2012-2022
Robert Racz, Akos Nagy, Zoltan Rakonczay , Erika Katalin Dunavari, Gabor Gerber and Gabor Varga*

Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach open Access plus

Volume: 24   Issue: 13
Pp: 1366-1376
Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*

Development of Peptide Vaccines in Dengue open Access plus

Volume: 24   Issue: 11
Pp: 1157-1173
Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh*

Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems open Access plus

Volume: 24   Issue: 6
Pp: 710-717
Osamu Kanauchi*, Akira Andoh, Sazaly AbuBakar and Naoki Yamamoto

Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity open Access plus

Volume: 24   Issue: 5
Pp: 576-594
Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macedo

Safety Strategies of Genetically Engineered T Cells in Cancer Immunotherapy open Access plus

Volume: 24   Issue: 1
Pp: 78-83
Yan-Bei Ren, Shang-Jun Sun and Shuang-Yin Han*

2-Hydroxypropyl-β-cyclodextrins and the Blood-Brain Barrier: Considerations for Niemann-Pick Disease Type C1 open Access plus

Volume: 23   Issue: 40
Pp: 6231-6238
Pericles Calias*

IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development open Access plus

Volume: 23   Issue: 38
Pp: 5964-5970
Ann Hellstrom*, David Ley, Boubou Hallberg, Chatarina Lofqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard

A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension open Access plus

Volume: 23   Issue: 34
Pp: 5191-5199
Louise M. Sorensen, Markus Wehland, Marcus Kruger, Ulf Simonsen, Mohamed Z. Nassef, Manfred Infanger and Daniela Grimm*

A Review of Chinese Herbal Medicine for the Treatment of Chronic Heart Failure open Access plus

Volume: 23   Issue: 34
Pp: 5115-5124
Yong Wang*, Qiyan Wang, Chun Li, Linghui Lu, Qian Zhang, Ruixin Zhu* and Wei Wang*

Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer open Access plus

Volume: 23   Issue: 32
Pp: 4827-4841
Jack Tuszynski, Tatiana M. Tilli and Michael Levin*

Protein Kinase Inhibitors as Therapeutic Drugs in AML: Advances and Challenges open Access plus

Volume: 23   Issue: 29
Pp: 4303-4310
Yuan Ling, Zikang Zhang, Hua Zhang* and Zunnan Huang*

Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress open Access plus

Volume: 23   Issue: 27
Pp: 4066-4075
Akinori Yanaka*

Hydrogel-Based Cell Therapies for Kidney Regeneration: Current Trends in Biofabrication and In Vivo Repair open Access plus

Volume: 23   Issue: 26
Pp: 3845-3857
Katja Jansen*, Carl C.L. Schuurmans*, Jitske Jansen, Rosalinde Masereeuw* and Tina Vermonden*

Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates open Access plus

Volume: 23   Issue: 15
Pp: 2276-2286
Ulviye Acar Cevik, Begum Nurpelin Saglik, Yusuf Ozkay*, Zerrin Canturk, Juan Bueno, Fatih Demirci and Ali Savas Koparal

Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin open Access plus

Volume: 23   Issue: 14
Pp: 2131-2138
Xinya Hemu and James P. Tam*

Anti-EGFRvIII Chimeric Antigen Receptor-Modified T Cells for Adoptive Cell Therapy of Glioblastoma open Access plus

Volume: 23   Issue: 14
Pp: 2113-2116
Pei-pei Ren, Ming Li, Tian-fang Li and Shuang-yin Han*

Selective Inhibition of Phosphodiesterases 4A, B, C and D Isoforms in Chronic Respiratory Diseases: Current and Future Evidences open Access plus

Volume: 23   Issue: 14
Pp: 2073-2083
Sonia Contreras*, Javier Milara*, Esteban Morcillo and Julio Cortijo

Neural Circuits Underlying Fly Larval Locomotion open Access plus

Volume: 23   Issue: 12
Pp: 1722-1733
Hiroshi Kohsaka*, Pierre A. Guertin and Akinao Nose

Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases open Access plus

Volume: 23   Issue: 7
Pp: 1077-1097
Lili Wang, Rufeng Ma, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Shuzhen Guo, Minke Tang, Yu Li, Jianzhao Niu, Min Fu, Sihua Gao* and Dongwei Zhang*

Polypharmacology in Precision Oncology: Current Applications and Future Prospects open Access plus

Volume: 22   Issue: 46
Pp: 6935-6945
Albert A. Antolin, Paul Workman, Jordi Mestres and Bissan Al-Lazikani

From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine open Access plus

Volume: 22   Issue: 46
Pp: 6903-6910
Cesar Pichardo-Almarza and Vanessa Diaz-Zuccarini

Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans open Access plus

Volume: 22   Issue: 44
Pp: 6701-6715
Mauro Serafini and Ilaria Peluso

Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored? open Access plus

Volume: 22   Issue: 40
Pp: 6107-6121
John Slattery, Derrick F. MacFabe, Stephen G. Kahler and Richard E. Frye

Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier open Access plus

Volume: 22   Issue: 35
Pp: 5463-5476
Nathalie Strazielle and Jean-François Ghersi-Egea

The Microbial Quality Aspects and Decontamination Approaches for the Herbal Medicinal Plants and Products: An in-Depth Review open Access plus

Volume: 22   Issue: 27
Pp: 4264-4287
Daniela Dal Molim Ghisleni, Marina de Souza Braga, Irene Satiko Kikuchi, Mirela Braşoveanu, Monica R. Nemţanu, Kamal Dua and Terezinha de Jesus Andreoli Pinto

AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species open Access plus

Volume: 22   Issue: 26
Pp: 3950-3970
Francesco Simone Ruggeri, Johnny Habchi, Andrea Cerreta and Giovanni Dietler

Miscellaneous Topics in Computer-Aided Drug Design: Synthetic Accessibility and GPU Computing, and Other Topics open Access plus

Volume: 22   Issue: 23
Pp: 3555-3568
Yoshifumi Fukunishi, Tadaaki Mashimo, Kiyotaka Misoo, Yoshinori Wakabayashi, Toshiaki Miyaki, Seiji Ohta, Mayu Nakamura and Kazuyoshi Ikeda

Therapeutic Targets for Management of Periodontitis and Diabetes open Access plus

Volume: 22   Issue: 15
Pp: 2216-2237
Corneliu Sima and Thomas E. Van Dyke

The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory open Access plus

Volume: 22   Issue: 12
Pp: 1756-1766
Mohammed I. Khan, Anna A. Sobocińska, Anna M. Czarnecka, Magdalena Król, Bruno Botta and Cezary Szczylik

Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier open Access plus

Volume: 22   Issue: 9
Pp: 1177-1193
David S. Hersh, Aniket S. Wadajkar, Nathan B. Roberts, Jimena G. Perez, Nina P. Connolly, Victor Frenkel, Jeffrey A. Winkles, Graeme F. Woodworth and Anthony J. Kim

Recent advances in the fundamental understanding of adhesive mixtures for inhalation open Access plus

Volume: 21   Issue: 40
Pp: 5900-5914
Floris Grasmeijer, Niels Grasmeijer, Paul Hagedoorn, Henderik Willem Frijlink and Anne Haaije de Boer

Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker open Access plus

Volume: 21   Issue: 26
Pp: 3797-3806
Kenji Hashimoto

Lipid-Based Nanocarriers for RNA Delivery open Access plus

Volume: 21   Issue: 22
Pp: 3140-3147
Hui Yi Xue, Pengbo Guo, Wu-Cheng Wen and Ho Lun Wong

Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations open Access plus

Volume: 21   Issue: 19
Pp: 2677-2694
Daryl R. Williams

Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus open Access plus

Volume: 21   Issue: 16
Pp: 2054-2057
Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi, Daniel R Knight, Carlo Viti, Graziella Orefici, Jose-Luis Martinez, Ana Teresa Freitas, Teresa M. Coque, Ian Morrissey and behalf of the BIOHYPO consortium

Macrophages in Immunopathology of Atherosclerosis: A Target for Diagnostics and Therapy open Access plus

Volume: 21   Issue: 9
Pp: 1172-1179
Alexander N. Orekhov, Igor A. Sobenin, Mikhail A. Gavrilin, Alexei Gratchev, Svetlana Y. Kotyashova, Nikita G. Nikiforov and Julia Kzhyshkowska

Assessment and Relevance of Carotid Intima-Media Thickness (C-IMT) in Primary and Secondary Cardiovascular Prevention open Access plus

Volume: 21   Issue: 9
Pp: 1164-1171
Alessio Ravani, Jose Pablo Werba, Beatrice Frigerio, Daniela Sansaro, Mauro Amato, Elena Tremoli and Damiano Baldassarre

Antihypertensive Drugs Metabolism: An Update to Pharmacokinetic Profiles and Computational Approaches open Access plus

Volume: 21   Issue: 6
Pp: 806-822
Aikaterini Zisaki, Ljubisa Miskovic and Vassily Hatzimanikatis

Targeting Cardiomyocyte Ca2+ Homeostasis in Heart Failure open Access plus

Volume: 21   Issue: 4
Pp: 431-448
Asmund T. Roe, Michael Frisk and William E. Louch

Biomarkers Predicting a Need for Intensive Treatment in Patients with Early Arthritis open Access plus

Volume: 21   Issue: 2
Pp: 170-181
I. Gonzalez-Alvaro, A.M. Ortiz, I.V. Seoane, R. Garcia-Vicuna, C. Martinez and R.P. Gomariz

Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy open Access plus

Volume: 20   Issue: 42
Pp: 6584-6643
Roger Gilabert-Oriol, Alexander Weng, Benedicta von Mallinckrodt, Matthias F. Melzig, Hendrik Fuchs and Mayank Thakur

Tankyrases: Structure, Function and Therapeutic Implications in Cancer open Access plus

Volume: 20   Issue: 41
Pp: 6472-6488
Teemu Haikarainen, Stefan Krauss and Lari Lehtio

Telomere Maintenance Mechanisms in Cancer: Clinical Implications open Access plus

Volume: 20   Issue: 41
Pp: 6361-6374
Roger R. Reddel

Mechanisms of Action of Anesthetics for the Modulation of Perioperative Thrombosis: Evidence for Immune Mechanisms from Basic and Clinical Studies open Access plus

Volume: 20   Issue: 36
Pp: 5779-5793
Toshiharu Azma, Florin Tuluc, Taishin Ito, Chikako Aoyama-Mani, Shinji Kawahito and Hiroyuki Kinoshita

Brain Innate Immunity in the Regulation of Neuroinflammation: Therapeutic Strategies by Modulating CD200-CD200R Interaction Involve the Cannabinoid System open Access plus

Volume: 20   Issue: 29
Pp: 4707-4722
Miriam Hernangomez, Francisco J. Carrillo-Salinas, Miriam Mecha, Fernando Correa, Leyre Mestre, Frida Loria, Ana Feliu, Fabian Docagne and Carmen Guaza

Dipeptidyl-peptidase 4 Inhibition: Linking Metabolic Control to Cardiovascular Protection open Access plus

Volume: 20   Issue: 14
Pp: 2387-2394
Angelo Avogaro, Saula de Kreutzenberg and Gianpaolo Fadini