Current Pharmaceutical Design

William A. Banks  
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Building 1, Room 810A
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Open Access Articles

Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates open Access plus

Volume: 23   Issue: 15
Pp: 2276-2286
Ulviye Acar Cevik, Begum Nurpelin Saglik, Yusuf Ozkay*, Zerrin Canturk, Juan Bueno, Fatih Demirci and Ali Savas Koparal
DOI:10.2174/1381612822666161201150131

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Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin open Access plus

Volume: 23   Issue: 14
Pp: 2131-2138
Xinya Hemu and James P. Tam*
DOI:10.2174/1381612822666161027120518

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Anti-EGFRvIII Chimeric Antigen Receptor-Modified T Cells for Adoptive Cell Therapy of Glioblastoma open Access plus

Volume: 23   Issue: 14
Pp: 2113-2116
Pei-pei Ren, Ming Li, Tian-fang Li* and Shuang-yin Han*
DOI:10.2174/1381612823666170316125402

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Neural Circuits Underlying Fly Larval Locomotion open Access plus

Volume: 23   Issue: 12
Pp: 1722-1733
Hiroshi Kohsaka*, Pierre A. Guertin and Akinao Nose
DOI:10.2174/1381612822666161208120835

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Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases open Access plus

Volume: 23   Issue: 7
Pp: 1077-1097
Lili Wang, Rufeng Ma, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Shuzhen Guo, Minke Tang, Yu Li, Jianzhao Niu, Min Fu, Sihua Gao* and Dongwei Zhang*
DOI:10.2174/1381612822666161010105242

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A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension open Access plus

Volume: 23   Issue:
Pp: 1-9
Louise Marqvard Sørensen, Markus Wehland, Marcus Krüger, Ulf Simonsen, Mohamed Zakaria Nassef, Manfred Infanger and Daniela Grimm*
DOI:10.2174/1381612823666170908114227

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2-Hydroxypropyl-β-cyclodextrins and the Blood-Brain Barrier: Considerations for Niemann-Pick Disease Type C1 open Access plus

Volume: 23   Issue:
Pp: 1-8
Pericles Calias*
DOI:10.2174/1381612823666171019164220

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Polypharmacology in Precision Oncology: Current Applications and Future Prospects open Access plus

Volume: 22   Issue: 46
Pp: 6935-6945
Albert A. Antolin, Paul Workman, Jordi Mestres and Bissan Al-Lazikani
DOI:10.2174/1381612822666160923115828

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From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine open Access plus

Volume: 22   Issue: 46
Pp: 6903-6910
Cesar Pichardo-Almarza and Vanessa Diaz-Zuccarini
DOI:10.2174/1381612822666160905095402

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Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans open Access plus

Volume: 22   Issue: 44
Pp: 6701-6715
Mauro Serafini and Ilaria Peluso
DOI:10.2174/1381612823666161123094235

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Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored? open Access plus

Volume: 22   Issue: 40
Pp: 6107-6121
John Slattery, Derrick F. MacFabe, Stephen G. Kahler and Richard E. Frye
DOI:10.2174/1381612822666160905123953

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Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier open Access plus

Volume: 22   Issue: 35
Pp: 5463-5476
Nathalie Strazielle and Jean-François Ghersi-Egea
DOI:10.2174/1381612822666160726112115

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The Microbial Quality Aspects and Decontamination Approaches for the Herbal Medicinal Plants and Products: An in-Depth Review open Access plus

Volume: 22   Issue: 27
Pp: 4264-4287
Daniela Dal Molim Ghisleni, Marina de Souza Braga, Irene Satiko Kikuchi, Mirela Braşoveanu, Monica R. Nemţanu, Kamal Dua and Terezinha de Jesus Andreoli Pinto
DOI:10.2174/1381612822666160623070829

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AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species open Access plus

Volume: 22   Issue: 26
Pp: 3950-3970
Francesco Simone Ruggeri, Johnny Habchi, Andrea Cerreta and Giovanni Dietler
DOI:10.2174/1381612822666160518141911

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Miscellaneous Topics in Computer-Aided Drug Design: Synthetic Accessibility and GPU Computing, and Other Topics open Access plus

Volume: 22   Issue: 23
Pp: 3555-3568
Yoshifumi Fukunishi, Tadaaki Mashimo, Kiyotaka Misoo, Yoshinori Wakabayashi, Toshiaki Miyaki, Seiji Ohta, Mayu Nakamura and Kazuyoshi Ikeda
DOI:10.2174/1381612822666160414142547

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Therapeutic Targets for Management of Periodontitis and Diabetes open Access plus

Volume: 22   Issue: 15
Pp: 2216-2237
Corneliu Sima and Thomas E. Van Dyke
DOI:10.2174/1381612822666160216150338

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The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory open Access plus

Volume: 22   Issue: 12
Pp: 1756-1766
Mohammed I. Khan, Anna A. Sobocińska, Anna M. Czarnecka, Magdalena Król, Bruno Botta and Cezary Szczylik
DOI:10.2174/1381612822666151211094901

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Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier open Access plus

Volume: 22   Issue: 9
Pp: 1177-1193
David S. Hersh, Aniket S. Wadajkar, Nathan B. Roberts, Jimena G. Perez, Nina P. Connolly, Victor Frenkel, Jeffrey A. Winkles, Graeme F. Woodworth and Anthony J. Kim
DOI:10.2174/1381612822666151221150733

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Recent advances in the fundamental understanding of adhesive mixtures for inhalation open Access plus

Volume: 21   Issue: 40
Pp: 5900-5914
Floris Grasmeijer, Niels Grasmeijer, Paul Hagedoorn, Henderik Willem Frijlink and Anne Haaije de Boer
DOI:10.2174/1381612821666151008124622

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Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker open Access plus

Volume: 21   Issue: 26
Pp: 3797-3806
Kenji Hashimoto
DOI:10.2174/1381612821666150605111345

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Lipid-Based Nanocarriers for RNA Delivery open Access plus

Volume: 21   Issue: 22
Pp: 3140-3147
Hui Yi Xue, Pengbo Guo, Wu-Cheng Wen and Ho Lun Wong
DOI:10.2174/1381612821666150531164540

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Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations open Access plus

Volume: 21   Issue: 19
Pp: 2677-2694
Daryl R. Williams
DOI:10.2174/1381612821666150416100319

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Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus open Access plus

Volume: 21   Issue: 16
Pp: 2054-2057
Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi, Daniel R Knight, Carlo Viti, Graziella Orefici, Jose-Luis Martinez, Ana Teresa Freitas, Teresa M. Coque, Ian Morrissey and behalf of the BIOHYPO consortium
DOI:10.2174/1381612821666150310103238

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Macrophages in Immunopathology of Atherosclerosis: A Target for Diagnostics and Therapy open Access plus

Volume: 21   Issue: 9
Pp: 1172-1179
Alexander N. Orekhov, Igor A. Sobenin, Mikhail A. Gavrilin, Alexei Gratchev, Svetlana Y. Kotyashova, Nikita G. Nikiforov and Julia Kzhyshkowska
DOI:10.2174/1381612820666141013120459

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Assessment and Relevance of Carotid Intima-Media Thickness (C-IMT) in Primary and Secondary Cardiovascular Prevention open Access plus

Volume: 21   Issue: 9
Pp: 1164-1171
Alessio Ravani, Jose Pablo Werba, Beatrice Frigerio, Daniela Sansaro, Mauro Amato, Elena Tremoli and Damiano Baldassarre
DOI:10.2174/1381612820666141013121545

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Antihypertensive Drugs Metabolism: An Update to Pharmacokinetic Profiles and Computational Approaches open Access plus

Volume: 21   Issue: 6
Pp: 806-822
Aikaterini Zisaki, Ljubisa Miskovic and Vassily Hatzimanikatis
DOI:10.2174/1381612820666141024151119

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Targeting Cardiomyocyte Ca2+ Homeostasis in Heart Failure open Access plus

Volume: 21   Issue: 4
Pp: 431-448
Asmund T. Roe, Michael Frisk and William E. Louch
DOI:10.2174/138161282104141204124129

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Biomarkers Predicting a Need for Intensive Treatment in Patients with Early Arthritis open Access plus

Volume: 21   Issue: 2
Pp: 170-181
I. Gonzalez-Alvaro, A.M. Ortiz, I.V. Seoane, R. Garcia-Vicuna, C. Martinez and R.P. Gomariz
DOI:10.2174/1381612820666140825123104

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Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy open Access plus

Volume: 20   Issue: 42
Pp: 6584-6643
Roger Gilabert-Oriol, Alexander Weng, Benedicta von Mallinckrodt, Matthias F. Melzig, Hendrik Fuchs and Mayank Thakur
DOI:10.2174/1381612820666140826153913

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Tankyrases: Structure, Function and Therapeutic Implications in Cancer open Access plus

Volume: 20   Issue: 41
Pp: 6472-6488
Teemu Haikarainen, Stefan Krauss and Lari Lehtio
DOI:10.2174/1381612820666140630101525

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Telomere Maintenance Mechanisms in Cancer: Clinical Implications open Access plus

Volume: 20   Issue: 41
Pp: 6361-6374
Roger R. Reddel
DOI:10.2174/1381612820666140630101047

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Mechanisms of Action of Anesthetics for the Modulation of Perioperative Thrombosis: Evidence for Immune Mechanisms from Basic and Clinical Studies open Access plus

Volume: 20   Issue: 36
Pp: 5779-5793
Toshiharu Azma, Florin Tuluc, Taishin Ito, Chikako Aoyama-Mani, Shinji Kawahito and Hiroyuki Kinoshita
DOI:10.2174/1381612820666140204102044

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Brain Innate Immunity in the Regulation of Neuroinflammation: Therapeutic Strategies by Modulating CD200-CD200R Interaction Involve the Cannabinoid System open Access plus

Volume: 20   Issue: 29
Pp: 4707-4722
Miriam Hernangomez, Francisco J. Carrillo-Salinas, Miriam Mecha, Fernando Correa, Leyre Mestre, Frida Loria, Ana Feliu, Fabian Docagne and Carmen Guaza
DOI:10.2174/1381612820666140130202911

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Dipeptidyl-peptidase 4 Inhibition: Linking Metabolic Control to Cardiovascular Protection open Access plus

Volume: 20   Issue: 14
Pp: 2387-2394
Angelo Avogaro, Saula de Kreutzenberg and Gianpaolo Fadini
DOI:10.2174/13816128113199990474

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Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings open Access plus

Volume: 20   Issue: 13
Pp: 2126-2137
Johannes Wrege, Andre Schmidt, Anna Walter, Renata Smieskova, Kerstin Bendfeldt, Ernst-Wilhelm Radue, Undine E. Lang and Stefan Borgwardt
DOI:10.2174/13816128113199990428

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New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis Treatment using VEGF Receptor Antibodies and Celecoxib open Access plus

Volume: 20   Issue: 7
Pp: 1097-1103
Masahiko Nakamura, Tetsufumi Takahashi, Hidenori Matsui, Shinichi Takahashi, Somay Y. Murayama, Hidekazu Suzuki and Kanji Tsuchimoto
DOI:10.2174/13816128113199990420

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Network Pharmacology Strategies Toward Multi-Target Anticancer Therapies: From Computational Models to Experimental Design Principles open Access plus

Volume: 20   Issue: 1
Pp: 23-36
Jing Tang and Tero Aittokallio
DOI:10.2174/13816128113199990470

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The µ Opioid Receptor and Ligands Acting at the µ Opioid Receptor, as Therapeutics and Potential Therapeutics open Access plus

Volume: 19   Issue: 42
Pp: 7415-7434
Mariana Spetea, Muhammad Faheem Asim, Gerhard Wolber and Helmut Schmidhammer
DOI:10.2174/13816128113199990362

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Functionalization of the Carbonyl Group in Position 6 of Morphinan-6-ones. Development of Novel 6-Amino and 6-Guanidino Substituted 14-Alkoxymorphinans open Access plus

Volume: 19   Issue: 42
Pp: 7391-7399
Helmut Schmidhammer, Mariana Spetea, Petra Windisch, Johannes Schütz, Pal Riba, Mahmoud Al-Khrasani and Susanna Furst
DOI:10.2174/138161281942140105164804

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Smart Stimuli Sensitive Nanogels in Cancer Drug Delivery and Imaging: A Review open Access plus

Volume: 19   Issue: 41
Pp: 7203-7218
S. Maya, Bruno Sarmento, Amrita Nair, N. Sanoj Rejinold, Shantikumar V. Nair and R. Jayakumar
DOI:10.2174/138161281941131219124142

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Mechanisms of Drug Resistance in Cancer Chemotherapy: Coordinated Role and Regulation of Efflux Transporters and Metabolizing Enzymes open Access plus

Volume: 19   Issue: 40
Pp: 7126-7140
Ramya Krishna Vadlapatla, Aswani Dutt Vadlapudi, Dhananjay Pal and Ashim K. Mitra
DOI:10.2174/13816128113199990493

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The Cellular Autophagy Markers Beclin-1 and LC3B-II are Increased During Reperfusion in Fibrillated Mouse Hearts open Access plus

Volume: 19   Issue: 39
Pp: 6912-6918
Gregory Meyer, Attila Czompa, Cyril Reboul, Evelin Csepanyi, Andras Czegledi, Istvan Bak, Gyorgy Balla, Jozsef Balla, Arpad Tosaki and Istvan Lekli
DOI:10.2174/138161281939131127122510

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Cardioprotective Effects of Sour Cherry Seed Extract (SCSE) on the Hypercholesterolemic Rabbit Heart open Access plus

Volume: 19   Issue: 39
Pp: 6896-6905
Bela Juhasz, Attila Kertész, Jozsef Balla, Gyorgy Balla, Zoltán Szabo, Mariann Bombicz, Daniel Priksz, Rudolf Gesztelyi, Balazs Varga, David D. Haines and Arpad Tosaki
DOI:10.2174/138161281939131127120517

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The STAT3 Inhibitor Stattic Impairs Cardiomyocyte Mitochondrial Function Through Increased Reactive Oxygen Species Formation open Access plus

Volume: 19   Issue: 39
Pp: 6890-6895
Kerstin Boengler, Elvira Ungefug, Gerd Heusch and Rainer Schulz
DOI:10.2174/138161281939131127115940

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Ghrelin as a Neuroprotective and Palliative Agent in Alzheimer's and Parkinson's Disease open Access plus

Volume: 19   Issue: 38
Pp: 6773-6790
Vanessa V. dos Santos, Ana Lúcia S. Rodrigues, Thereza C. De Lima, Susana R. de Barioglio, Rita Raisman-Vozari and Rui D. Prediger
DOI:10.2174/13816128113199990411

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Iron Oxide Nanoparticle-induced Oxidative Stress and Genotoxicity in Human Skin Epithelial and Lung Epithelial Cell Lines open Access plus

Volume: 19   Issue: 37
Pp: 6681-6690
Maqusood Ahamed, Hisham A. Alhadlaq, Javed Alam, M. A. Majeed Khan, Daoud Ali and Saud Alarafi
DOI:10.2174/1381612811319370011

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Nanomaterials for Photohyperthermia: A Review open Access plus

Volume: 19   Issue: 37
Pp: 6622-6634
Jonathan Fang and Yu-Chie Chen
DOI:10.2174/1381612811319370006

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Recent Advances in Superparamagnetic Iron Oxide Nanoparticles for Cellular Imaging and Targeted Therapy Research open Access plus

Volume: 19   Issue: 37
Pp: 6575-6593
Yi-Xiang J. Wang, Shouhu Xuan, Marc Port and Jean-Marc Idee
DOI:10.2174/1381612811319370003

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Immunization Against Active Ghrelin Using Virus-Like Particles for Obesity Treatment open Access plus

Volume: 19   Issue: 36
Pp: 6551-6558
Sara Andrade, Filipa Pinho, Andreia M. Ribeiro, Marcos Carreira, Felipe F. Casanueva, Polly Roy and Mariana P. Monteiro
DOI:10.2174/13816128113199990506

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Diffusion Tensor Imaging to Determine Effects of Antidementive Treatment on Cerebral Structural Connectivity in Alzheimer’s Disease open Access plus

Volume: 19   Issue: 36
Pp: 6416-6425
Ingo Kilimann, Yuttachai Likitjaroen, Harald Hampel and Stefan Teipel
DOI:10.2174/1381612811319360003

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Anti-miRNA-23a Oligonucleotide Suppresses Glioma Cells Growth by Targeting Apoptotic Protease Activating Factor-1 open Access plus

Volume: 19   Issue: 35
Pp: 6382-6389
Shizhong Lian, Ruyi Shi, Tao Bai, Yang Liu, Wang Miao, Hongqin Wang, Xiaodong Liu and Yimin Fan
DOI:10.2174/13816128113199990509

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Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases open Access plus

Volume: 19   Issue: 35
Pp: 6375-6381
Toru Ishibashi
DOI:10.2174/13816128113199990507

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The Smart Targeting of Nanoparticles open Access plus

Volume: 19   Issue: 35
Pp: 6315-6329
Adam D. Friedman, Sarah E. Claypool and Rihe Liu
DOI:10.2174/13816128113199990375

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Nanostructed Cubosomes as Advanced Drug Delivery System open Access plus

Volume: 19   Issue: 35
Pp: 6290-6297
Xin Pan, Ke Han, Xinsheng Peng, Zhiwen Yang, Lingzhen Qin, Chune Zhu, Xintian Huang, Xuan Shi, Linghui Dian, Ming Lu and Chuanbin Wu
DOI:10.2174/1381612811319350006

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Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence open Access plus

Volume: 19   Issue: 34
Pp: 6064-6093
Joao Tomé-Carneiro, Mar Larrosa, Antonio González-Sarrías, Francisco A. Tomás-Barberán, María Teresa García-Conesa and Juan Carlos Espín
DOI:10.2174/13816128113199990407

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Mitochondrial Mutations in Atherosclerosis: New Solutions in Research and Possible Clinical Applications open Access plus

Volume: 19   Issue: 33
Pp: 5942-5953
Igor A. Sobenin, Dimitry A. Chistiakov, Yuri V. Bobryshev, Anton Y. Postnov and Alexander N. Orekhov
DOI:10.2174/1381612811319330013

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Role of Adiponectin in the Metabolic Syndrome: Current Perspectives on its Modulation as a Treatment Strategy open Access plus

Volume: 19   Issue: 32
Pp: 5755-5763
Indira Padmalayam and Mark Suto
DOI:10.2174/13816128113199990360

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Hyperglycemia-induced Oxidative Stress and its Role in Diabetes Mellitus Related Cardiovascular Diseases open Access plus

Volume: 19   Issue: 32
Pp: 5695-5703
Teresa Vanessa Fiorentino, Annamaria Prioletta, Pengou Zuo and Franco Folli
DOI:10.2174/1381612811319320005

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N-Glycosylation of Plant-produced Recombinant Proteins open Access plus

Volume: 19   Issue: 31
Pp: 5503-5512
Dirk Bosch, Alexandra Castilho, Andreas Loos, Arjen Schots and Herta Steinkellner
DOI:10.2174/1381612811319310006

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Commercial Aspects of Pharmaceutical Protein Production in Plants open Access plus

Volume: 19   Issue: 31
Pp: 5471-5477
Rainer Fischer, Stefan Schillberg, Johannes F. Buyel and Richard M. Twyman
DOI:10.2174/1381612811319310002

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The Culture-Repopulating Ability Assays and Incubation in Low Oxygen: A Simple Way to Test Drugs on Leukaemia Stem or Progenitor Cells open Access plus

Volume: 19   Issue: 30
Pp: 5374-5383
Maria Grazia Cipolleschi, Elisabetta Rovida and Persio Dello Sbarba
DOI:10.2174/1381612811319300006

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New Molecular Targets in the Treatment of NSCLC open Access plus

Volume: 19   Issue: 30
Pp: 5333-5343
Clorinda Schettino, Maria Anna Bareschino, Paola Claudia Sacco, Paolo Maione, Antonio Rossi, Francesca Casaluce, Assunta Sgambato and Cesare Gridelli
DOI:10.2174/13816128113199990343

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Genetic Predisposition in NAFLD and NASH: Impact on Severity of Liver Disease and Response to Treatment open Access plus

Volume: 19   Issue: 29
Pp: 5219-5238
Paola Dongiovanni, Quentin M. Anstee and Luca Valenti
DOI:10.2174/13816128113199990381

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Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD open Access plus

Volume: 19   Issue: 29
Pp: 5177-5192
Amedeo Lonardo, Silvia Sookoian, Michel Chonchol, Paola Loria and Giovanni Targher
DOI:10.2174/1381612811319290003

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Epidemiology and Natural History of Patients with NAFLD open Access plus

Volume: 19   Issue: 29
Pp: 5169-5176
Neeraj Bhala, Ramy Ibrahim Kamal Jouness and Elisabetta Bugianesi
DOI:10.2174/13816128113199990336

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Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders open Access plus

Volume: 19   Issue: 28
Pp: 5051-5064
Luis M. Valor, Jose Viosca, Jose P. Lopez-Atalaya and Angel Barco
DOI:10.2174/13816128113199990382

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Histone Acetylation: From Code to Web and Router Via Intrinsically Disordered Regions open Access plus

Volume: 19   Issue: 28
Pp: 5019-5042
Masami Horikoshi
DOI:10.2174/1381612811319280002

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Treatment of Foot Disease in Patients with Type 2 Diabetes Mellitus using Human Umbilical Cord Blood Mesenchymal Stem Cells: Response and Correction of Immunological Anomalies open Access plus

Volume: 19   Issue: 27
Pp: 4893-4899
Xiao-Yan Li, Zhao-Hui Zheng, Xue-Yi Li, Jian Guo, Yan Zhang, Hui Li, Yang-Wei Wang, Jun Ren and Zhen-Biao Wu
DOI:10.2174/13816128113199990326

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MicroRNA-34a Promotes Cardiomyocyte Apoptosis Post Myocardial Infarction Through Down-regulating Aldehyde Dehydrogenase 2 open Access plus

Volume: 19   Issue: 27
Pp: 4865-4873
Fan Fan, Aijun Sun, Hangtian Zhao, Xiangwei Liu, Wenbin Zhang, Xueting Jin, Cong Wang, Xin Ma, Cheng Shen, Yunzeng Zou, Kai Hu and Junbo Ge
DOI:10.2174/13816128113199990325

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Cardiac Dysfunction and Oxidative Stress in the Metabolic Syndrome: an Update on Antioxidant Therapies open Access plus

Volume: 19   Issue: 27
Pp: 4806-4817
Olesya Ilkun and Sihem Boudina
DOI:10.2174/1381612811319270003