Current Pharmaceutical Design


William A. Banks  
Seattle VA Puget Sound Health Care System
Room 810C, Building 1
1660 S. Columbian Way
Seattle, WA 98108


Editor's Choice

Redox Sensitive Polysaccharide Based Nanoparticles for Improved Cancer Treatment: A Comprehensive Review

Volume: 24   Issue: 28
Pp: 3303-3319
Erfaneh Ghassami, Jaleh Varshosaz and Somayeh Taymouri*
DOI: 10.2174/1381612824666180813114841

Metallothionein: A Novel Therapeutic Target for Treatment of Inflammatory Bowel Disease

Volume: 24   Issue: 27
Pp: 3155-3161
Kristen E. Dostie, Amy V. Thees and Michael A. Lynes*
DOI: 10.2174/1381612824666180717110236

Concept of Hematopoietic and Stromal Niches for Cell-Based Diagnostics and Regenerative Medicine (a Review)

Volume: 24   Issue: 26
Pp: 3034-3054
Igor A. Khlusov*, Larisa S. Litvinova, Marina Yu. Khlusova and Kristina A. Yurova
DOI: 10.2174/1381612824666180829154119

Microvascular (dys)Function in Stable Coronary Artery Disease: Cross Talk with Epicardial Segments

Volume: 24   Issue: 25
Pp: 2900-2905
Lucian Calmac, Vlad Bataila, Bogdan Dragoescu, Cosmin Mihai, Alexandru Scafa-Udriste and Maria Dorobantu*
DOI: 10.2174/1381612824666180702113448

The Mechanism of Exosomes Function in Neurological Diseases: A Progressive Review

Volume: 24   Issue: 24
Pp: 2855-2861
Mengchen Yuan, Nan Liu, Xiaofeng Wang, Chao Tian, Xiaomeng Ren, Hanlai Zhang, Xinyu Yang, Xinye Li, Haiyan Zhu, Lingqun Zhu, Hongcai Shang, Yanwei Xing* and Yonghong Gao*
DOI: 10.2174/1381612824666180903113136

Targeted Liposomes for siRNA Delivery to Cancer

Volume: 24   Issue: 23
Pp: 2664-2672
Josimar O. Eloy, Raquel Petrilli, Giovanni Loureiro Raspantini and Robert J. Lee*
DOI: 10.2174/1381612824666180807121935

The Role of Neuroimaging in the Diagnosis and Treatment of Depressive Disorder: A Recent Review

Volume: 24   Issue: 22
Pp: 2515-2523
Tianbin Song, Xiaowei Han, Lei Du, Jing Che, Jing Liu, Sumin Shi, Chao Fu, Wenwen Gao, Jie Lu* and Guolin Ma*
DOI: 10.2174/1381612824666180727111142

Phase Behavior of Polymorphic Fats in Drug Delivery Systems - A Review of the State of Art

Volume: 24   Issue: 21
Pp: 2508-2512
Joana R. Campos, Ana R. Fernandes, Patricia Severino, Maria L. Gracia, Selma B. Souto and Eliana B. Souto*
DOI: 10.2174/1381612824666180522092740

Parkinson’s Disease: Alpha Synuclein, Heme Oxygenase and Biotherapeutic Countermeasures

Volume: 24   Issue: 20
Pp: 2317-2321
David D. Haines*, Maxim V. Trushin, Stephen Rose, Iloki Assanga Simon Bernard and Fadia F. Mahmoud
DOI: 10.2174/1381612824666180717161338

The Potential Mechanisms of Exercise-induced Cognitive Protection: A Literature Review

Volume: 24   Issue: 17
Pp: 1827-1831
Jennifer E. Norman*, Jennifer Rutkowsky, Sue Bodine and John C. Rutledge
DOI: 10.2174/1381612824666180406105149

Diabetes-Related Neurological Implications and Pharmacogenomics

Volume: 24   Issue: 15
Pp: 1695-1710
Camilo Andres Rojas-Carranza, Rosa Helena Bustos-Cruz*, Carmen Juliana Pino-Pinzon, Yeimy Viviana Ariza-Marquez, Rosa Margarita Gomez-Bello and Marisa Canadas-Garre
DOI: 10.2174/1381612823666170317165350

The Role of Inflammation in Neurological Disorders

Volume: 24   Issue: 14
Pp: 1485-1501
Diana Degan, Raffaele Ornello, Cindy Tiseo, Antonio Carolei, Simona Sacco and Francesca Pistoia*
DOI: 10.2174/1381612824666180327170632

Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach open access plus

Volume: 24   Issue: 13
Pp: 1366-1376
Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*
DOI: 10.2174/1381612824666171201115126

New Imaging Tracers for the Infected Diabetic Foot (Nuclear and Optical Imaging)

Volume: 24   Issue: 12
Pp: 1287-1303
Alfred O. Ankrah, Hans C. Klein and Philip H. Elsinga*
DOI: 10.2174/1381612824666180227094454

Immunotheraphy in Allergic Diseases

Volume: 24   Issue: 11
Pp: 1174-1194
Albert Roger, Maria Basagana, Aina Teniente-Serra, Nathalie Depreux, Yanina Jurgens, Clara Padro, Sira Miquel, Carolina Elduque and Eva M. Martinez-Caceres*
DOI: 10.2174/1381612824666180116094048

Lactoferrin and Peptide-derivatives: Antimicrobial Agents with Potential Use in Nonspecific Immunity Modulation

Volume: 24   Issue: 10
Pp: 1067-1078
Maria Elisa Drago-Serrano, Rafael Campos-Rodriguez, Julio Cesar Carrero* and Mireya de la Garza*
DOI: 10.2174/1381612824666180327155929

The Modification and Design of Antimicrobial Peptide

Volume: 24   Issue: 8
Pp: 904-910
Yidan Gao, Hengtong Fang, Lu Fang, Dawei Liu, Jinsong Liu, Menghan Su, Zhi Fang, Wenzhi Ren* and Huping Jiao*
DOI: 10.2174/1381612824666180213130318

Current Status of Molecular Imaging in Inflammatory and Autoimmune Disorders

Volume: 24   Issue: 7
Pp: 743-753
Alberto Signore*, Kelly Luz Anzola, Sveva Auletta, Michela Varani, Agnese Petitti, Marta Pacilio, Filippo Galli and Chiara Lauri
DOI: 10.2174/1381612824666180130115153

Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems open access plus

Volume: 24   Issue: 6
Pp: 710-717
Osamu Kanauchi*, Akira Andoh, Sazaly AbuBakar and Naoki Yamamoto
DOI: 10.2174/1381612824666180116163411

Current Delivery Strategies to Improve the Target of Cell Penetrating Peptides Used for Tumor-Related Therapeutics

Volume: 24   Issue: 5
Pp: 541-548
Fang Zhang, Dandan Yang, Shanshan Jiang, Lei Wu, Li Qin, Huiyang He and Peng Zhang*
DOI: 10.2174/1381612823666170728094922

Curcumin as an Adjunct Therapy and microRNA Modulator in Breast Cancer promotion: free to download

Volume: 24   Issue: 2
Pp: 171-177
Saeed Norouzi, Muhammed Majeed, Matteo Pirro, Daniele Generali and Amirhossein Sahebkar*
DOI: 10.2174/1381612824666171129203506

Statins and Oxidative Stress in the Cardiovascular System

Volume: 23   Issue: 46
Pp: 7040-7047
Marios Margaritis, Fabio Sanna and Charalambos Antoniades*
DOI: 10.2174/1381612823666170926130338

Intranasal Lipid Nanoparticles for the Treatment of Neurodegenerative Diseases

Volume: 23   Issue: 43
Pp: 6553-6562
S. Cunha, H. Almeida, M.H. Amaral*, J.M. Sousa Lobo and A.C. Silva*
DOI: 10.2174/1381612824666171128105305

Antiepileptics for Post-Traumatic Seizure Prophylaxis after Traumatic Brain Injury

Volume: 23   Issue: 42
Pp: 6428-6441
Alexander G. Chartrain, Kurt Yaeger, Rui Feng, Marios S. Themistocleous, Neha S. Dangayach, Konstantinos Margetis and Zachary L. Hickman*
DOI: 10.2174/1381612823666171031100139

Bone-Muscle Crosstalk: Unraveling New Therapeutic Targets for Osteoporosis

Volume: 23   Issue: 41
Pp: 6256-6263
Anna Picca, Riccardo Calvani*, Ester Manes-Gravina, Leonardo Spaziani, Francesco Landi, Roberto Bernabei and Emanuele Marzetti
DOI: 10.2174/1381612823666170526112300

Preterm Birth and Neonatal Injuries: Importance of Interleukin-1 and Potential of Interleukin-1 Receptor Antagonists

Volume: 23   Issue: 40
Pp: 6132-6141
Mathieu Nadeau-Vallee, Dima Obari, Alexandra Beaudry-Richard, Estefania Marin Sierra, Alexandre Beaulac, Noemie Maurice, David M. Olson* and Sylvain Chemtob*
DOI: 10.2174/1381612823666170825145114

The Roles of microRNAs in Regulating Chemotherapy Resistance of Non-Small Cell Lung Cancer

Volume: 23   Issue: 39
Pp: 5983-5988
Xiaoxuan Wei, Xiaoyan Shen, Yanchen Ren and Weidong Hu*
DOI: 10.2174/1381612823666171018105207

Long-term Effects of Early Exposure to Stress, Pain, Opioids and Anaesthetics on Pain Sensitivity and Neurocognition

Volume: 23   Issue: 38
Pp: 5879-5886
Gerbrich E. van den Bosch, Monique van Dijk, Dick Tibboel and Jurgen C. de Graaff*
DOI: 10.2174/1381612823666170926150259

Inflammation and Epilepsy: Preclinical Findings and Potential Clinical Translation

Volume: 23   Issue: 37
Pp: 5569-5576
Gaetano Terrone, Alessia Salamone and Annamaria Vezzani*
DOI: 10.2174/1381612823666170926113754

Post Mortem Redistribution of Drugs: Current State of Knowledge

Volume: 23   Issue: 36
Pp: 5530-5541
Caroline Sastre, Christophe Bartoli, Valerie Baillif-Couniou, Georges Leonetti and Anne-Laure Pelissier-Alicot*
DOI: 10.2174/1381612823666170622111739

Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

Volume: 23   Issue: 35
Pp: 5213-5229
Sally Sabra, Mona Abdelmoneem, Mahmoud Abdelwakil, Moustafa Taha Mabrouk, Doaa Anwar, Rania Mohamed, Sherine Khattab, Adnan Bekhit, Kadria Elkhodairy, May Freag and Ahmed Elzoghby*
DOI: 10.2174/1381612823666170526111029

Modulation of both Insulin Resistance and Cancer Growth by Inositol

Volume: 23   Issue: 34
Pp: 5200-5210
Mariano Bizzarri*, Simona Dinicola* and Alessandra Cucina
DOI: 10.2174/1381612823666170830123634

Aquaporin 4 in Astrocytes is a Target for Therapy in Alzheimer's Disease

Volume: 23   Issue: 33
Pp: 4948-4957
Yu-Long Lan, Jian-Jiao Chen, Gang Hu, Jun Xu, Ming Xiao* and Shao Li*
DOI: 10.2174/1381612823666170714144844

Micro-RNA Profiling as a Predictor of Clinical Outcomes for Head and Neck Cancer Patients

Volume: 23   Issue: 32
Pp: 4729-4744
Tatyana Isayeva*, Margaret Brandwein-Gensler , Maheshika Somarathna , Lakisha D. Moore-Smith and Timmy Lee
DOI: 10.2174/1381612823666170601100633

Obesity-Induced Hypertension: New Insights

Volume: 23   Issue: 31
Pp: 4620-4625
Christina Antza, Stella Stabouli, Michalis Natsis, Ioannis Doundoulakis and Vasilios Kotsis*
DOI: 10.2174/1381612823666170608083343

Hormones and Sarcopenia

Volume: 23   Issue: 30
Pp: 4484-4492
John E. Morley*
DOI: 10.2174/1381612823666161123150032

Adiponectin as a Potential Therapeutic Target for Prostate Cancer

Volume: 23   Issue: 28
Pp: 4170-4179
Hanuma Kumar Karnati*, Manas Kumar Panigrahi, Yazhou Li, David Tweedie and Nigel H. Greig*
DOI: 10.2174/1381612823666170208123553

The Role of Stress in Inflammatory Bowel Diseases

Volume: 23   Issue: 27
Pp: 3997-4002
Dolores Sgambato, Agnese Miranda, Rocco Ranaldo, Alessandro Federico and Marco Romano*
DOI: 10.2174/1381612823666170228123357

Neuroprotection in Hypoxic-Ischemic Brain Injury Targeting Glial Cells open access plus

Volume: 23   Issue: 26
Pp: 3899-3906
Maria Ines Herrera*, Sofia Mucci*, George E. Barreto, Rodolfo Kolliker-Frers and Francisco Capani*
DOI: 10.2174/1381612823666170727145422

Recent Advances on the Role of microRNAs in both Insulin Resistance and Cancer

Volume: 23   Issue: 25
Pp: 3658-3666
Adele Vivacqua*, Paola De Marco, Antonino Belfiore and Marcello Maggiolini*
DOI: 10.2174/1381612823666170622105123

Gene Delivery with Organic Electronic Biomaterials

Volume: 23   Issue: 24
Pp: 3614-3625
Kathryn F.A. Clancy and John G. Hardy*
DOI: 10.2174/1381612823666170710124137

Polyamine Transport and Synthesis in Trichomonas vaginalis: Potential Therapeutic Targets

Volume: 23   Issue: 23
Pp: 3359-3366
Maria Elizbeth Alvarez-Sanchez, Jose Luis Villalpando, Laura Itzel Quintas-Granados and Rossana Arroyo*
DOI: 10.2174/1381612823666170703162754

Gut Microbiota: A New Marker of Cardiovascular Disease

Volume: 23   Issue: 22
Pp: 3233-3238
Antonio Garcia-Rios, Jose David Torres-Peña, Francisco Perez-Jimenez and Pablo Perez-Martinez*
DOI: 10.2174/1381612823666170317144853

miR-126 as a Therapeutic Agent for Diabetes Mellitus

Volume: 23   Issue: 22
Pp: 3309-3314
Elham Pishavar and Javad Behravan*
DOI: 10.2174/1381612823666170424120121

BDNF/NF-κB Signaling in the Neurobiology of Depression

Volume: 23   Issue: 21
Pp: 3154-3163
Ariel Caviedes, Carlos Lafourcade, Claudio Soto and Ursula Wyneken*
DOI: 10.2174/1381612823666170111141915

Surface Engineered Dendrimers in siRNA Delivery and Gene Silencing

Volume: 23   Issue: 20
Pp: 2952-2975
Vishakha Tambe, Shreya Thakkar, Nidhi Raval, Dilip Sharma, Kiran Kalia and Rakesh K. Tekade*
DOI: 10.2174/1381612823666170314104619

Food as Pharma? The Case of Glucosinolates

Volume: 23   Issue: 19
Pp: 2697-2721
Edoardo Capuano*, Matthijs Dekker, Ruud Verkerk and Teresa Oliviero
DOI: 10.2174/1381612823666170120160832

Cytokines Induced During Influenza Virus Infection

Volume: 23   Issue: 18
Pp: 2616-2622
Tatiana Betakova*, Anna Kostrabova, Veronika Lachova and Lucia Turianova
DOI: 10.2174/1381612823666170316123736

Curcumin and Endothelial Function: Evidence and Mechanisms of Protective Effects

Volume: 23   Issue: 17
Pp: 2462-2473
Maryam S. Karimian, Matteo Pirro, Thomas P. Johnston, Muhammed Majeed and Amirhossein Sahebkar*
DOI: 10.2174/1381612823666170222122822

Gut Microbiota Modulation and Anti-Inflammatory Properties of Dietary Polyphenols in IBD: New and Consolidated Perspectives

Volume: 23   Issue: 16
Pp: 2344-2351
Angelo Santino*, Aurelia Scarano, Stefania De Santis, Maria De Benedictis, Giovanna Giovinazzo and Marcello Chieppa*
DOI: 10.2174/1381612823666170207145420

MicroRNAs as Big Regulators of Neural Stem/Progenitor Cell Proliferation, Differentiation and Migration: A Potential Treatment for Stroke

Volume: 23   Issue: 15
Pp: 2252-2257
Qian Zhang, Kaiyuan Zhang, Chao Zhang, Hongfei Ge, Yi Yin, Hua Feng* and Rong Hu*
DOI: 10.2174/1381612823666170228124657

Introduction for Design of Nanoparticle Based Drug Delivery Systems

Volume: 23   Issue: 14
Pp: 2108-2112
Jun Yan Chan Edgar and Hui Wang*
DOI: 10.2174/1381612822666161025154003

Traumatic Brain Injury: Preclinical Imaging Diagnostic(s) and Therapeutic Approaches open access plus

Volume: 23   Issue: 13
Pp: 1909-1915
Eric L. Kaijzel*, Ermond R. van Beek, Marieke A. Stammes, Ivo Que, Alan B. Chan, Clemens W.G.M. Lowik and Luis J. Cruz
DOI: 10.2174/1381612823666170116141116

Targeting Obesity for the Prevention of Chronic Cardiovascular Disease Through Gut Microbiota-Herb Interactions: An Opportunity for Traditional Herbs

Volume: 23   Issue: 8
Pp: 1142-1152
Feng Chen, Jun Jiang*, Dan-Dan Tian, Qi Wen, Yong-Hui Li, Jun-Qing Zhang, Chen Cheng and Tengfei Wang*
DOI: 10.2174/1381612822666161014115724

The Role of Biologically Active Ingredients from Chinese Herbal Medicines in the Regulation of Autophagy in Treating Cardiovascular Diseases and Other Chronic Diseases

Volume: 23   Issue: 7
Pp: 1060-1069
Jie Li, Yonghong Gao, Xiaomeng Ren, Yanda Li, Lijun Wu, Xinyu Yang, Jie Wang, Hongcai Shang, Xingjiang Xiong* and Yanwei Xing*
DOI: 10.2174/1381612822666161021161850

PPAR Agonists, Atherogenic Dyslipidemia and Cardiovascular Risk

Volume: 23   Issue: 6
Pp: 894-902
Dragana Nikolic, Giuseppa Castellino, Maciej Banach, Peter P. Toth, Ekaterina Ivanova, Alexander N. Orekhov, Giuseppe Montalto and Manfredi Rizzo
DOI: 10.2174/1381612822666161006151134

miRNAs: New Biomarkers and Therapeutic Targets in Dementia

Volume: 23   Issue: 5
Pp: 669-692
Ana Teresa de Barros Viegas, Joana Ribeiro Guedes, Ana Rafaela Oliveira, Ana Maria Sequeira Cardoso and Ana Luisa Colaco Cardoso
DOI: 10.2174/1381612823666170111094702

Glaucoma: Hot Topics in Pharmacology

Volume: 23   Issue: 4
Pp: 596-607
Shiama I. Balendra, Parth Arvind Shah, Mishank Jain, Andrzej Grzybowski and Maria F. Cordeiro
DOI: 10.2174/1381612822666161129151308

Membrane-Based Technologies in the Pharmaceutical Industry and Continuous Production of Polymer-Coated Crystals/Particles

Volume: 23   Issue: 2
Pp: 242-249
Dengyue Chen, Kamalesh K. Sirkar, Chi Jin, Dhananjay Singh and Robert Pfeffer
DOI: 10.2174/1381612822666161025145229

Predictive Biomarkers for Linking Disease Pathology and Drug Effect

Volume: 23   Issue: 1
Pp: 29-54
Bernd Mayer, Andreas Heinzel, Arno Lukas and Paul Perco
DOI: 10.2174/1381612822666161006153639

Genetic Predictors of Drug Hypersensitivity

Volume: 22   Issue: 45
Pp: 6725-6733
Jose A. Cornejo-Garcia, Abderrahim Oussalah, Miguel Blanca, Rosa-Maria Gueant-Rodriguez, Cristobalina Mayorga, Julie Waton, Annick Barbaud, Francesco Gaeta, Antonino Romano and Jean-Louis Gueant
DOI: 10.2174/1381612822666160927114941

Development of Novel miRNA-based Vaccines and Antivirals against Enterovirus 71

Volume: 22   Issue: 44
Pp: 6694-6700
Pinn Tsin Isabel Yee and Chit Laa Poh
DOI: 10.2174/1381612822666160720165613

Unraveling Antibody Display: Systems Biology and Personalized Medicine

Volume: 22   Issue: 43
Pp: 6560-6576
Luiz Ricardo Goulart, Paula Souza Santos, Ana Paula Carneiro, Barbara Brasil Santana, Antonio C. Vallinoto and Thaise Goncalves Araujo
DOI: 10.2174/1381612822666160923112816