Manuscripts submitted for research and review articles in the respective journal should be divided into the following sections:
A graphic should be included when possible with each manuscript for use in the Table of Contents (TOC). This must be submitted separately as an electronic file (preferred file types are EPS, PDF, TIFF, Microsoft Word, PowerPoint and CDX etc.). A graphical abstract, not exceeding 30 words along with the illustration, helps to summarize the contents of the manuscript in a concise pictorial form. It is meant as an aid for the rapid viewing of the journals' contents and to help capture the readers’ attention. The graphical abstract may feature a key structure, reaction, equation, etc. that the manuscript elucidates upon. It will be listed along with the manuscript title, authors’ names and affiliations in the contents page, typeset within an area of 5 cm by 17 cm, but it will not appear in the article's PDF file or in print.
Graphical Abstracts should be submitted as a separate file (must clearly mention graphical abstract within the file) online via Bentham's Content Management System by selecting the option “Supplementary material”.
The main text should begin on a separate page and should be divided into title page, abstract and the main text. The text may be subdivided further according to the areas to be discussed, which should be followed by the List of Abbreviations, Conflict of Interest, Acknowledgements and Reference sections. For Research Articles/ Letters the manuscript should begin with the title page and abstract followed by the main text, which must be structured into separate sections as Introduction, Materials and Methods, Results, Discussion, Conclusion, List of Abbreviations, Conflict of Interest, Acknowledgements and References. For Reviews, the manuscript should be divided into title page, abstract and the main text. The text may be subdivided further according to the areas to be discussed, which should be followed by the List of Abbreviations, Conflict of Interest, Acknowledgements and Reference sections. The Review Article should mention any previous important recent and old reviews in the field and contain a comprehensive discussion starting with the general background of the field. It should then go on to discuss the salient features of recent developments. The authors should avoid presenting material which has already been published in a previous review.
The authors are advised to present and discuss their observations in brief. The manuscript style must be uniform throughout the text and 10 pt Times New Roman font should be used. The full term for an abbreviation should precede its first appearance in the text unless it is a standard unit of measurement. The reference numbers should be given in square brackets in the text. Italics should be used for Binomial names of organisms (Genus and Species), for emphasis and for unfamiliar words or phrases. Non-assimilated words from Latin or other languages should also be italicized e.g. in vivo, in vitro, per se, et al. etc.
Section headings should be numbered sequentially, left aligned and have the first letter capitalized, starting with the introduction. Sub-section headings however, should be in lower-case and italicized with their initials capitalized. They should be numbered as 1.1, 1.2, etc.
The Introduction section should include the background and aims of the research in a comprehensive manner.
MATERIALS AND METHODS:
This section provides details of the methodology used along with information on any previous efforts with corresponding references. Any details for further modifications and research should be included.
Repeated information should not be reported in the text of an article. A calculation section must include experimental data, facts and practical development from a theoretical perspective.
Results should be precise.
This should explore the significance of the results of the work, and present reproducible procedure. Extensive citations and discussion of published literature should be avoided.
The Results and discussions may be presented individually or combined in a single section with short and informative headings.
A small paragraph summarizing the contents of the article, presenting the final outcome of the research or proposing further study on the subject, may be given at the end of the article under the Conclusion section.
Standard Protocol on Approvals, Registrations, Patient Consents & Animal Protection:
All clinical investigations must be conducted according to the Declaration of Helsinki principles. Authors must comply with the guidelines of the International Committee of Medical Journal Editors (www.icmje.org) with regard to the patient’s consent for research or participation in a study. Patients' names, initials, or hospital numbers must not be mentioned anywhere in the manuscript (including figures). Editors may request that authors provide documentation of the formal review and recommendation from the institutional review board or ethics committee responsible for oversight of the study.
In addition to the standard patient consent for participation in research, authors are responsible for obtaining patient consent-to-disclose forms for all recognizable patients in photographs, videos, or other information that may be published in the Journal, in derivative works, or on the journal’s web site and for providing the manuscript to the recognizable patient for review before submission. The consent-to-disclose form should indicate specific use (publication in the medical literature in print and online, with the understanding that patients and the public will have access) of the patient's information and any images in figures or videos, and must contain the patient's signature or that of a legal guardian along with a statement that the patient or legal guardian has been offered the opportunity to review the identifying materials and the accompanying manuscript.
For research involving animals, the authors should indicate whether the procedures followed were in accordance with the standards set forth in the eighth edition of Guide for the Care and Use of Laboratory Animals (grants.nih.gov/grants/olaw/guide-for-the-care-and-use-of-laboratory-animals_prepub.pdf; published by the National Academy of Sciences, The National Academies Press, Washington, D.C.).
Research Involving Animals:
Research work on animals should be carried out in accordance with the NC3Rs ARRIVE Guidelines. For In Vivo Experiments, visit https://www.nc3rs.org.uk/arrive-guidelines
Authors must clearly state the name of the approval committee, highlighting that legal and ethical approval was obtained prior to initiation of the research work carried out on animals, and that the experiments were performed in accordance with the relevant guidelines and regulations stated below.
Registration of Systematic Reviews:
Bentham Science Publishers supports retrospective registration of systematic reviews, in a suitable registry (such as PROSPERO). The registered systematic review must include the registration number as the last line of the manuscript abstract.
Consent for Publication:
If the manuscript has an individuals’ data, such as personal detail, audio-video material etc., consent should be obtained from that individual. In case of children, consent should be obtained from the parent or the legal guardian.
A specific declaration of such approval and consent-to-disclose form must be made in the copyright letter and in a stand-alone paragraph at the end of the article especially in the case of human studies where inclusion of a statement regarding obtaining the written informed consent from each subject or subject's guardian is a must. The original should be retained by the guarantor or corresponding author. Editors may request to provide the original forms by fax or email.
All such case reports should be followed by a proper consent prior to publishing.
Authentication of Cell Lines:
The NIH acknowledges the misidentification and/or cross-contamination of cell cultures e.g. HeLa cells being used in a research study as a serious problem. In order to ensure the validation of the work and proper utilization of resources, it is a prerequisite that correct reagents be used in studies dealing with established human (tumor) cell lines that have been cultured for more than 4 years up to the date of submission of the manuscript. Cell lines such as short-term cultures of human tumors, murine cell lines (as a catalog of DNA profiles is not yet available) and tumor cell lines established in the course of the study that is being submitted, are presently exempt from this rule. To minimize the risk of working with misidentified and/or contaminated cell lines, tests such as isoenzyme analysis, karyotyping/cytogenetic analysis and, more recently, molecular techniques of DNA profiling may be carried out to authenticate cell cultures. These tests may help confirm or establish the identify profile for a cell line. Bentham Science recommends that all cell lines be authenticated prior to submitting a paper for review. Authors are therefore required to provide authentication of the origin and identity of the cells by performing cell profiling either in their own laboratory or by outsourcing an approved laboratory or cell bank. Authentication is required when a new line is established or acquired , before freezing a cell line, if the performance of the line is not consistent or results are unexpected, if using more than one cell line, and before publication of the study.
The cell lines profile should be cross-checked with the profile of the donor tissue of other continuous cell lines such as provided by the authentic data bank such as www.dsmz.de/fp/cgi-bin/str.html, ATCC®etc.
Randomized Drug Clinical Trial Studies:
Randomized drug clinical trial studies are biomedical or health-related interventional and/or observational research studies conducted in phases in human beings who will be randomly allocated to receive or not receive a preventive, therapeutic, or diagnostic intervention that follows a pre-defined protocol. The study is intended to find out whether promising approaches to the disease prevention, diagnosis, and treatment are safe and effective.
All randomized clinical trials should include a flow diagram and authors should provide a completed randomized trial checklist (see CONSORT Flow Diagram and Checklist; www.consort-statement.org) and a trial protocol. Authors of randomized controlled trials are encouraged to submit trial protocols along with their manuscripts. All clinical trials must be registered (before recruitment of the first participant) at an appropriate online public trial registry that must be independent of for-profit interest. Trial registry name, registration identification number, and the URL for the registry should be included at the end of the abstract and also in the space provided on the online manuscript submission form. If your research article reports the results of a controlled health care intervention, list your trial registry, along with the unique identifying number. Note that there should be no space between the letters and numbers of your trial registration number. Studies designed for other purposes, such as to study pharmacokinetics or major toxicity (e.g., phase 1 trials), are exempt.
Each manuscript should clearly state an objective or hypothesis; the design and methods (including the study setting and dates, patients or participants with inclusion and exclusion criteria, or data sources, and how these were selected for the study); the essential features of any interventions; the main outcome measures; the main results of the study; a comment section placing the results in context with the published literature and addressing study limitations; and the conclusions. Data included in research reports must be original.
Greek Symbols and Special Characters:
Greek symbols and special characters often undergo formatting changes and get corrupted or lost during preparation of manuscript for publication. To ensure that all special characters used are embedded in the text, these special characters should be inserted as a symbol but should not be a result of any format styling (Symbol font face) otherwise they will be lost during conversion to PDF/XML.
Authors are encouraged to consult reporting guidelines. These guidelines provide a set of recommendations comprising a list of items relevant to their specific research design. Chemical equations, chemical names, mathematical usage, unit of measurements, chemical and physical quantity & units must conform to SI and Chemical Abstracts or IUPAC.
All kinds of measurements should be reported only in International System of Units (SI).
All individuals listed as authors must have contributed substantially to the design, performance, analysis, or reporting of the work and are required to indicate their specific contribution. Anyone (individual/company/institution) who has substantially contributed to the study for important intellectual content, or who was involved in the article’s drafting the manuscript or revising must also be acknowledged.
Guest or honorary authorship based solely on position (e.g. research supervisor, departmental head) is discouraged.
The specific requirements for authorship have been defined by the International Committee of Medical Journal Editors (ICMJE; www.icmje.org). Examples of authors' contributions are: 'designed research/study', 'performed research/study', 'contributed important reagents', 'collected data', 'analyzed data', 'wrote paper' etc. This information must be included in the submitted manuscript as a separate paragraph under the heading ‘Acknowledgements’. The corresponding author is responsible for obtaining permission from all co-authors for the submission of any version of the manuscript and for any changes in the authorship.
All authors must strictly follow the guidelines below for preparing illustrations for publication in Current Gene Therapy. If the figures are found to be sub-standard, then the manuscripts will be rejected/ and the authors offered the option of figure improvement professionally by Eureka Science. The costs for such improvement will be charged to the authors.
Illustrations should be embedded in the text file, and must be numbered consecutively in the order of their appearance. Each figure should include only a single illustration which should be cropped to minimize the amount of space occupied by the illustration.
If a figure is in separate parts, all parts of the figure must be provided in a single composite illustration file.
Photographs should be provided with a scale bar if appropriate, as well as high-resolution component files.
Line Art image type is normally an image based on lines and text. It does not contain tonal or shaded areas. The preferred file format should be TIFF or EPS, with the color mode being Monochrome 1-bit or RGB, in a resolution of 900-1200 dpi.
Halftone image type is a continuous tone photograph containing no text. It should have the preferred file format TIFF, with color mode being RGB or Grayscale, in a resolution of 300 dpi.
Combination image type is an image containing halftone , text or line art elements. It should have the preferred file format TIFF, with color mode being RGB or Grayscale, in a resolution of 500-900 dpi.
Illustrations may be submitted in the following file formats:
EPS (preferred format for diagrams)
PDF (also especially suitable for diagrams)
PNG (preferred format for photos or images)
Microsoft Word (version 5 and above; figures must be a single page)
PowerPoint (figures must be a single page)
JPEG (conversion should be done using the original file)
Bentham Science Publishers does not process figures submitted in GIF format.
For TIFF or EPS figures with considerably large file size restricting the file size in online submissions is advisable. Authors may therefore convert to JPEG format before submission as this results in significantly reduced file size and upload time, while retaining acceptable quality. JPEG is a ‘lossy’ format. However, in order to maintain acceptable image quality, it is recommended that JPEG files are saved at High or Maximum quality.
Zipit or Stuffit tools should not be used to compress files prior to submission as the resulting compression through these tools is always negligible.
Please refrain from supplying:
- Graphics embedded in word processor (spreadsheet, presentation) document.
- Optimized files optimized for screen use (like GIF, BMP, PICT, WPG) because of the low resolution.
- Files with too low a resolution.
- Graphics that are disproportionately large for the content.
Image Conversion Tools:
There are many software packages, many of them freeware or shareware, capable of converting to and from different graphics formats, including PNG.
General tools for image conversion include Graphic Converter on the Macintosh, Paint Shop Pro, for Windows, and ImageMagick, available on Macintosh, Windows and UNIX platforms.
Bitmap images (e.g. screenshots) should not be converted to EPS as they result in a much larger file size than the equivalent JPEG, TIFF, PNG or BMP, and poor quality. EPS should only be used for images produced by vector-drawing applications such as Adobe Illustrator or CorelDraw. Most vector-drawing applications can be saved in, or exported as, EPS format. If the images were originally prepared in an Office application, such as Word or PowerPoint, original Office files should be directly uploaded to the site, instead of being converted to JPEG or another format of low quality.
- The cost for each individual page of color figures/plates/illustrations is US$ 997.
- Color figures should be supplied in CMYK and not in RGB colors.
Note for authors: To maintain publication quality, figures submitted in colour will be published in colour only.
We do encourage to append supportive material, for example a PowerPoint file containing information about the study, a PowerPoint file containing additional screenshots, a Word, RTF, or PDF document showing the original instrument(s) used, a video, or the original data (SAS/SPSS files, MS Excel files, Access Db files etc.) provided it is inevitable or endorsed by the journal's Editor.
Supportive/Supplementary material intended for publication must be numbered and referred to in the manuscript but should not be a part of the submitted paper. In-text citations as well as a section with the heading "Supportive/Supplementary Material" before the "References" section should be provided. All Supportive/Supplementary Material must be listed and a brief caption line for each file describing its contents should be included.
Any additional files will be linked to the final published article in the form supplied by the author, but will not be displayed within the paper. They will be made available in exactly the same form as originally provided only on our Web site. Please also make sure that each additional file is a single table, figure or movie (please do not upload linked worksheets or PDF files larger than one sheet). Supportive/ Supplementary material must be provided in a single zipped file not larger than 4 MB.
Authors must clearly indicate if these files are not for publication but meant for the reviewers'/editors' perusal only.