ISSN (Print): 1570-159X
ISSN (Online): 1875-6190
Volume 16, 10 Issues, 2018
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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190
Aims & Scope
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Ranking and Category:
69 th of 261 in Neurosciences 40 th of 261 in Pharmacology & Pharmacy
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T.E. Salt University College London Institute of Ophthalmology London EC1V 9EL UK
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Special Issue Submission
"By providing succinct reviews of recent advances, Current Neuropharmacology will greatly facilitate readers' comprehension of the big picture."
Solomon H. Snyder
Johns Hopkins Univ., USA
GLAUCOMA: IN SEARCH OF BETTER NEUROTHERAPEUTICS
Guest Editor(s): Rossella Russo, Giacinto Bagetta
Tentative Publication Date: July, 2018
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NICOTINE AND THE NICOTINIC CHOLINERGIC SYSTEM IN HEALTH AND DISEASE
Guest Editor(s): Sakire Pogun
Thank you very much for your mail. Our experience with Bentham Science Publishers has been very positive.
Pedraza Carmen (Departamento de Psicobiologia y Metodologia en las CC, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Malaga, Malaga, Spain.)
Has contributed: Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA1 Pathway
This hot topic issue reviews the most up to date literature dealing with pathophysiology
mechanisms underlying RGC death with the scope to propose new venues for the discovery of better
therapeutics on a rational basis.
Neurodegenerative diseases include Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS),
Parkinson's disease (PD), and Huntington's disease. These diseases involve different aspects of reward
processing (primary rewards, secondary rewards, reward-based learning, and reward-based decisionmaking).
About 70% of the population with 65 years or more are affected by these progressive
neurodegenerative disorders of the central nervous system and characterized by gradual loss of cognitive
function, progressive memory loss, disorientation, language impairment, abnormal behavior, personality
changes, etc Theoretical studies using in silico methods have aided in the process of drug discovery.
Technological advances in the areas of structural characterization, computational science, and molecular
biology have contributed to faster planning of new feasible molecules. Chemoinformatic studies show
that a large fraction of compoundss are “drug-like” or at least, “lead-like” having structural and
physicochemical properties that render them as potential drugs or leads. This thematic issue will bring
together theoretical studies of different methodologies, such as QSAR, docking, chemometric tools,
artificial intelligence and other applied in order to optimize the search for new drugs for the cure and
treatment of neurodegenerative diseases.
Traditionally, neuroscientists regarded glial functions as simply providing physical support
and maintenance for neurons. Thus, in this limited role glia had been long ignored. Recently,
glial functions have been gradually investigated, and increasing evidence has suggested that glial
cells perform important roles in various brain functions. Digging up the glial functions and
further understanding of these crucial cells, and the interaction between neurons and glia may
shed new light on clarifying many unknown aspects including the mind-brain gap, and
conscious-unconscious relationships. It is well known that CNS inflammation and immune
activation play a major role in the pathophysiology of neurodegenerative diseases. Although the
blood-brain barrier is able to protect the CNS from immune activation, it becomes more
permeable during inflammation, which renders the brain vulnerable to infections. A better
understanding of the interaction between inflammatory mediators, such as cytokines, and the
activated immune response, including astrocytes and microglia, is critical for the development of
new therapeutic strategies for neurodegenerative diseases.
The goal of this SI is to review the relationship of neuron-glia and cytokines in the
pathophysiology of neuropsychiatric disorders and the mechanisms of action of drugs used for
their treatment. The SI provides evidences for the role of the inflammation induced toxic
metabolites from the tryptophan pathway in neuropsychiatric disorders such as depression,
schizophrenia, and Alzheimer's disease and so on. A better understanding of the interaction
between cytokines, glia and neurons provide new strategies for the development of novel
therapeutic targets for neuropsychiatric disorders.
This themed issue aims to bring together recent findings in basic and clinical sciences with a
translational perspective that will cover the involvement of the nicotinic cholinergic system not only in
physiological functions but also in disease states, including but not limited to tobacco addiction, as well
as drug development.
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