Abstract
Conventional insecticides are highly toxic to many living organisms as well as to the environment; consequently, new biorational and more specific approaches to pest control have been developed. In this paper, we present an update of those approaches resulting from studies on inhibition of enzymes involved in key processes of insects life, particularly growth, molting and development of larvae and intraspecific communication of adults. The enzymes covered include pheromone degrading enzymes, pheromone biosynthetic enzymes, oxidoreductases, juvenile hormones, juvenile hormone epoxide hydrolases, proteases, molting hormones and phenoloxidases. Although these approaches refer to control of insect pests, many of them can be in principle also considered suitable for medicinal chemistry studies, since the mechanism of action of these inhibitors on related enzymes is quite similar, if not equal, in both fields.
Keywords: enzyme inhibitors, pest control, pheromone degrading enzymes, pheromone biosynthetic enzymes, oxidoreductases, juvenile hormones, proteases, molting hormones, phenoloxidases
Current Medicinal Chemistry
Title: Biorational Approaches for Insect Control by Enzymatic Inhibition
Volume: 12 Issue: 4
Author(s): Angel Guerrero and Gloria Rosell
Affiliation:
Keywords: enzyme inhibitors, pest control, pheromone degrading enzymes, pheromone biosynthetic enzymes, oxidoreductases, juvenile hormones, proteases, molting hormones, phenoloxidases
Abstract: Conventional insecticides are highly toxic to many living organisms as well as to the environment; consequently, new biorational and more specific approaches to pest control have been developed. In this paper, we present an update of those approaches resulting from studies on inhibition of enzymes involved in key processes of insects life, particularly growth, molting and development of larvae and intraspecific communication of adults. The enzymes covered include pheromone degrading enzymes, pheromone biosynthetic enzymes, oxidoreductases, juvenile hormones, juvenile hormone epoxide hydrolases, proteases, molting hormones and phenoloxidases. Although these approaches refer to control of insect pests, many of them can be in principle also considered suitable for medicinal chemistry studies, since the mechanism of action of these inhibitors on related enzymes is quite similar, if not equal, in both fields.
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Cite this article as:
Guerrero Angel and Rosell Gloria, Biorational Approaches for Insect Control by Enzymatic Inhibition, Current Medicinal Chemistry 2005; 12 (4) . https://dx.doi.org/10.2174/0929867053363126
DOI https://dx.doi.org/10.2174/0929867053363126 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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