Abstract
During the past five years, several members of the KCNQ potassium channel gene family have been identified with a high degree of CNS specificity. Within the KCNQ family, the combination of the KCNQ2 / KCNQ3 proteins, and the KCNQ5 / KCNQ3 arrangement has been identified as the molecular correlates of the different M-currents. Several lines of evidence are emerging demonstrating the importance of these channels in regulating neuronal excitability; for example, determination of the excitability threshold, firing properties, and responsiveness of neurons to synaptic inputs. Recent studies have shown that KCNQ openers have potential for the treatment of several CNS disorders characterized by neuronal hyperexcitability, such as migraine, epilepsy and neuropathic pain. This article reviews the recent developments of KCNQ potassium channel openers.
Keywords: KCNQ potassium, M-currents, CNS disorders, neuropathic pain, epilepsy, migraine
Current Medicinal Chemistry
Title: Recent Developments on KCNQ Potassium Channel Openers
Volume: 12 Issue: 4
Author(s): Yong-Jin Wu and Steven I. Dworetzky
Affiliation:
Keywords: KCNQ potassium, M-currents, CNS disorders, neuropathic pain, epilepsy, migraine
Abstract: During the past five years, several members of the KCNQ potassium channel gene family have been identified with a high degree of CNS specificity. Within the KCNQ family, the combination of the KCNQ2 / KCNQ3 proteins, and the KCNQ5 / KCNQ3 arrangement has been identified as the molecular correlates of the different M-currents. Several lines of evidence are emerging demonstrating the importance of these channels in regulating neuronal excitability; for example, determination of the excitability threshold, firing properties, and responsiveness of neurons to synaptic inputs. Recent studies have shown that KCNQ openers have potential for the treatment of several CNS disorders characterized by neuronal hyperexcitability, such as migraine, epilepsy and neuropathic pain. This article reviews the recent developments of KCNQ potassium channel openers.
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Cite this article as:
Wu Yong-Jin and Dworetzky I. Steven, Recent Developments on KCNQ Potassium Channel Openers, Current Medicinal Chemistry 2005; 12 (4) . https://dx.doi.org/10.2174/0929867053363045
DOI https://dx.doi.org/10.2174/0929867053363045 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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