Current Medicinal Chemistry

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

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Open Access Articles

Xanthine Oxidoreductase in Drug Metabolism: Beyond a Role as a Detoxifying Enzyme open Access plus

Volume: 23   Issue: 35
Pp: 4027-4036
Maria Giulia Battelli, Letizia Polito, Massimo Bortolotti and Andrea Bolognesi
DOI:10.2174/0929867323666160725091915

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Osteoimmunology and Beyond open Access plus

Volume: 23   Issue: 33
Pp: 3754-3774
Lia Ginaldi and Massimo De Martinis
DOI:10.2174/0929867323666160907162546

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Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain open Access plus

Volume: 23   Issue: 26
Pp: 2908-2928
Katarzyna Popiolek-Barczyk and Joanna Mika
DOI:10.2174/0929867323666160607120124

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Why Antidiabetic Vanadium Complexes are Not in the Pipeline of “Big Pharma” Drug Research? A Critical Review open Access plus

Volume: 23   Issue: 25
Pp: 2874-2891
Thomas Scior, Jose Antonio Guevara-Garcia, Quoc-Tuan Do, Philippe Bernard and Stefan Laufer
DOI:10.2174/0929867323666160321121138

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A Compendium of Volatile Organic Compounds (VOCs) Released By Human Cell Lines open Access plus

Volume: 23   Issue: 20
Pp: 2112-2131
Wojciech Filipiak, Pawel Mochalski, Anna Filipiak, Clemens Ager, Raquel Cumeras, Cristina E. Davis, Agapios Agapiou, Karl Unterkofler and Jakob Troppmair
DOI:10.2174/0929867323666160510122913

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Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults open Access plus

Volume: 23   Issue: 17
Pp: 1725-1755
Mieke De Buck, Mieke Gouwy, Ji Ming Wang, Jacques Van Snick, Ghislain Opdenakker, Sofie Struyf and Jo Van Damme
DOI:10.2174/0929867323666160418114600

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Current Advances in Developing Inhibitors of Bacterial Multidrug Efflux Pumps open Access plus

Volume: 23   Issue: 10
Pp: 1062-1081
Hannah Y. Mahmood, Shirin Jamshidi, J. Mark Sutton and Khondaker M. Rahman
DOI:10.2174/0929867323666160304150522

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Food Proteins as Source of Opioid Peptides-A Review open Access plus

Volume: 23   Issue: 9
Pp: 893-910
Swati Garg, Kulmira Nurgali and Vijay Kumar Mishra
DOI:10.2174/0929867323666160219115226

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Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases open Access plus

Volume: 23   Issue: 8
Pp: 792-815
Marisa Cabeza, Araceli Sánchez-Márquez, Mariana Garrido, Aylín Silva and Eugene Bratoeff
DOI:10.2174/0929867323666160210125642

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Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson’s Disease open Access plus

Volume: 23   Issue: 7
Pp: 686-700
Ikuko Miyazaki and Masato Asanuma
DOI:10.2174/0929867323666160122115057

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Role of Tyrosine Isomers in Acute and Chronic Diseases Leading to Oxidative Stress - A Review open Access plus

Volume: 23   Issue: 7
Pp: 667-685
Gergő A. Molnár, Szilárd Kun, Eszter Sélley, Melinda Kertész, Lívia Szélig, Csaba Csontos, Katalin Böddi, Lajos Bogár, Attila Miseta and István Wittmann
DOI:10.2174/0929867323666160119094516

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Eosinophils in Cancer: Favourable or Unfavourable? open Access plus

Volume: 23   Issue: 7
Pp: 650-666
Samy Sakkal, Sarah Miller, Vasso Apostolopoulos and Kulmira Nurgali
DOI:10.2174/0929867323666160119094313

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A “Double-Edged” Scaffold: Antitumor Power within the Antibacterial Quinolone open Access plus

Volume: 23   Issue: 6
Pp: 520-577
Gregory S. Bisacchi and Michael R. Hale
DOI:10.2174/0929867323666151223095839

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Action of Nanoparticles on Platelet Activation and Plasmatic Coagulation open Access plus

Volume: 23   Issue: 5
Pp: 408-430
Eleonore Fröhlich
DOI:10.2174/0929867323666160106151428

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Lipoprotein-Related and Apolipoprotein-Mediated Delivery Systems for Drug Targeting and Imaging open Access plus

Volume: 22   Issue: 31
Pp: 3631-3651
Gunter Almer, Harald Mangge, Andreas Zimmer and Ruth Prassl
DOI:10.2174/0929867322666150716114625

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Non-Traditional Systemic Treatments for Diabetic Retinopathy: An Evidence-Based Review open Access plus

Volume: 22   Issue: 21
Pp: 2580-2589
Rafael Simo, Stefania Ballarini, Jose Cunha-Vaz, Linong Ji, Hermann Haller, Paul Zimmet and Tien Y Wong
DOI:10.2174/0929867322666150520095923

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Bacteriophages and Phage-Derived Proteins – Application Approaches open Access plus

Volume: 22   Issue: 14
Pp: 1757-1773
Zuzanna Drulis-Kawa, Grazyna Majkowska-Skrobek and Barbara Maciejewska
DOI:10.2174/0929867322666150209152851

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Key Sites for P2X Receptor Function and Multimerization: Overview of Mutagenesis Studies on a Structural Basis open Access plus

Volume: 22   Issue: 7
Pp: 799-818
Ralf Hausmann, Achim Kless and Gunther Schmalzing
DOI:10.2174/0929867322666141128163215

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Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease open Access plus

Volume: 22   Issue: 3
Pp: 373-404
Natalia Guzior, Anna Wieckowska, Dawid Panek and Barbara Malawska
DOI:10.2174/0929867321666141106122628

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Novel Strategies for Preventing Diabetes and Obesity Complications with Natural Polyphenols open Access plus

Volume: 22   Issue: 1
Pp: 150-164
C. Carpene, S. Gomez-Zorita, S. Deleruyelle and M.A. Carpene
DOI:10.2174/0929867321666140815124052

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Interactions Between Nanosized Materials and the Brain open Access plus

Volume: 21   Issue: 37
Pp: 4200-4214
M. Simko and Mats-Olof Mattsson
DOI:10.2174/0929867321666140716100449

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A Common Molecular Motif Characterizes Extracellular Allosteric Enhancers of GPCR Aminergic Receptors and Suggests Enhancer Mechanism of Action open Access plus

Volume: 21   Issue: 32
Pp: 3673-3686
Robert Root-Bernstein and Patrick F. Dillon
DOI:10.2174/0929867321666140826120604

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Atrial Natriuretic Peptide: A Magic Bullet for Cancer Therapy Targeting Wnt Signaling and Cellular pH Regulators open Access plus

Volume: 21   Issue: 21
Pp: 2401-2409
A. Serafino and P. Pierimarchi
DOI:10.2174/0929867321666140205140152

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In Vitro and In Vivo Models for Analysis of Resistance to Anticancer Molecular Therapies open Access plus

Volume: 21   Issue: 14
Pp: 1595-1606
Roberta Rosa, Francesca Monteleone, Nicola Zambrano and Roberto Bianco
DOI:10.2174/09298673113209990226

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Histopathological Determinants of Tumor Resistance: A Special Look to the Immunohistochemical Expression of Carbonic Anhydrase IX in Human Cancers open Access plus

Volume: 21   Issue: 14
Pp: 1569-1582
G. Ilardi, N. Zambrano, F. Merolla, M. Siano, S. Varricchio, M. Vecchione, G. De Rosa, M. Mascolo and S. Staibano
DOI:10.2174/09298673113209990227

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Exogenous Hormonal Regulation in Breast Cancer Cells by Phytoestrogens and Endocrine Disruptors open Access plus

Volume: 21   Issue: 9
Pp: 1129-1145
A. Albini, C. Rosano, G. Angelini, A. Amaro, A.I. Esposito, S. Maramotti, D.M. Noonan and U. Pfeffer
DOI:10.2174/0929867321666131129124640

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Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic? open Access plus

Volume: 21   Issue: 6
Pp: 663-688
G. Curia, C. Lucchi, J. Vinet, F. Gualtieri, C. Marinelli, A. Torsello, L. Costantino and G. Biagini
DOI:10.2174/0929867320666131119152201

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Phytoestrogens in Postmenopause: The State of the Art from a Chemical, Pharmacological and Regulatory Perspective open Access plus

Volume: 21   Issue: 4
Pp: 417-436
Elisabetta Poluzzi, Carlo Piccinni, Emanuel Raschi, Angela Rampa, Maurizio Recanatini and Fabrizio De Ponti
DOI:10.2174/09298673113206660297

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An Update on Autoinflammatory Diseases open Access plus

Volume: 21   Issue: 3
Pp: 261-269
F. Ciccarelli, M. De Martinis and L. Ginaldi
DOI:10.2174/09298673113206660303

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An Up-date of Olive Oil Phenols in Inflammation and Cancer: Molecular Mechanisms and Clinical Implications open Access plus

Volume: 20   Issue: 37
Pp: 4758-4776
A. Cárdeno, M. Sánchez-Hidalgo and C. Alarcón-de-la-Lastra
DOI:10.2174/09298673113209990159

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Reduction of Breast Cancer Relapses with Perioperative Non-Steroidal Anti-Inflammatory Drugs: New Findings and a Review open Access plus

Volume: 20   Issue: 33
Pp: 4163-4176
Michael Retsky, Romano Demicheli, William J.M. Hrushesky, Patrice Forget, Marc De Kock, Isaac Gukas, Rick A Rogers, Michael Baum, Vikas Sukhatme and Jayant S. Vaidya
DOI:10.2174/09298673113209990250

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Medicinal Chemistry of the Epigenetic Diet and Caloric Restriction open Access plus

Volume: 20   Issue: 32
Pp: 4050-4059
S. L. Martin, T. M. Hardy and T. O. Tollefsbol
DOI:10.2174/09298673113209990189

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Neuroprotective Properties of Curcumin in Alzheimer’s Disease – Merits and Limitations open Access plus

Volume: 20   Issue: 32
Pp: 3955-3985
Dawn Chin, Patricia Huebbe, Kathrin Pallauf and Gerald Rimbach
DOI:10.2174/09298673113209990210

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Free Fatty Acids-Sensing G Protein-Coupled Receptors in Drug Targeting and Therapeutics open Access plus

Volume: 20   Issue: 31
Pp: 3855-3871
Tomo Yonezawa, Riho Kurata, Kaori Yoshida, Masanori A. Murayama, Xiaofeng Cui and Akihiko Hasegawa
DOI:10.2174/09298673113209990168

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Tuberculosis Clinical Trial Update and the Current Anti-Tuberculosis Drug Portfolio open Access plus

Volume: 20   Issue: 30
Pp: 3785-3796
Juan Carlos Palomino and Anandi Martin
DOI:10.2174/09298673113209990166

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A Novel Promising Therapeutic Option Against Hepatitis C Virus: An Oral Nucleotide NS5B Polymerase Inhibitor Sofosbuvir open Access plus

Volume: 20   Issue: 30
Pp: 3733-3742
I. Gentile, F. Borgia, A. R. Buonomo, G. Castaldo and G. Borgia
DOI:10.2174/09298673113209990178

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Reactive Oxygen Species in Cancer Biology and Anticancer Therapy open Access plus

Volume: 20   Issue: 30
Pp: 3677-3692
Y. Yang, S. Karakhanova, J. Werner and A. V. Bazhin
DOI:10.2174/0929867311320999165

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MicroRNAs and Cancer Therapy – From Bystanders to Major Players open Access plus

Volume: 20   Issue: 29
Pp: 3561-3573
Cornelia Braicu, George A. Calin and Ioana Berindan-Neagoe
DOI:10.2174/0929867311320290002

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Neurodegeneration in the Pathogenesis of Diabetic Retinopathy: Molecular Mechanisms and Therapeutic Implications open Access plus

Volume: 20   Issue: 26
Pp: 3241-3250
Maxwell S. Stem and Thomas W. Gardner
DOI:10.2174/09298673113209990027

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Mitochondria Damage in the Pathogenesis of Diabetic Retinopathy and in the Metabolic Memory Associated with its Continued Progression open Access plus

Volume: 20   Issue: 26
Pp: 3226-3233
Renu A. Kowluru
DOI:10.2174/09298673113209990029

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Calpains: Potential Targets for Alternative Chemotherapeutic Intervention Against Human Pathogenic Trypanosomatids open Access plus

Volume: 20   Issue: 25
Pp: 3174-3185
M. H. Branquinha, F. A. Marinho, L. S. Sangenito, S. S.C. Oliveira, K. C. Goncalves, V. Ennes-Vidal, C. M. d’Avila-Levy and A. L.S. Santos
DOI:10.2174/0929867311320250010

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Aspartic Peptidases of Human Pathogenic Trypanosomatids: Perspectives and Trends for Chemotherapy open Access plus

Volume: 20   Issue: 25
Pp: 3116-3133
L. O. Santos, A. S. Garcia-Gomes, M. Catanho, C. L. Sodre, A. L.S. Santos, M. H. Branquinha and C. M. d’Avila-Levy
DOI:10.2174/0929867311320250007

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Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African Trypanosomiasis open Access plus

Volume: 20   Issue: 25
Pp: 3103-3115
I. M.D. Bastos, F. N. Motta, P. Grellier and J. M. Santana
DOI:10.2174/0929867311320250006

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Synthetic and Natural Protease Inhibitors Provide Insights into Parasite Development, Virulence and Pathogenesis open Access plus

Volume: 20   Issue: 25
Pp: 3078-3102
A. A. Rascon and J. H. McKerrow
DOI:10.2174/0929867311320250005

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n-3 Fatty Acids: Role in Neurogenesis and Neuroplasticity open Access plus

Volume: 20   Issue: 24
Pp: 2953-2963
R. Crupi, A. Marino and S. Cuzzocrea
DOI:10.2174/09298673113209990140

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An Overview on Natural Polysaccharides with Antioxidant Properties open Access plus

Volume: 20   Issue: 23
Pp: 2899-2913
H. Wang, Y. M. Liu, Z. M. Qi, S. Y. Wang, S. X. Liu, X. Li, H. J. Wang and X. C. Xia
DOI:10.2174/0929867311320230006

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Virtual Screening Strategies in Drug Discovery: A Critical Review open Access plus

Volume: 20   Issue: 23
Pp: 2839-2860
A. Lavecchia and C. Di Giovanni
DOI:10.2174/09298673113209990001

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Trypanosomatidae Diseases: From the Current Therapy to the Efficacious Role of Trypanothione Reductase in Drug Discovery open Access plus

Volume: 20   Issue: 21
Pp: 2673-2696
L.S.C. Bernardes, C.L. Zani and I. Carvalho
DOI:10.2174/0929867311320210005

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Flavonoids in Atherosclerosis: An Overview of Their Mechanisms of Action open Access plus

Volume: 20   Issue: 21
Pp: 2641-2660
G. Siasos, D. Tousoulis, V. Tsigkou, E. Kokkou, E. Oikonomou, M. Vavuranakis, E.K. Basdra, A.G. Papavassiliou and C. Stefanadis
DOI:10.2174/0929867311320210003

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Bioavailability of Quercetin: Problems and Promises open Access plus

Volume: 20   Issue: 20
Pp: 2572-2582
X. Cai, Z. Fang, J. Dou, A. Yu and G. Zhai
DOI:10.2174/09298673113209990120

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Clinical and Marketed Proteasome Inhibitors for Cancer Treatment open Access plus

Volume: 20   Issue: 20
Pp: 2537-2551
Jiankang Zhang, Peng Wu and Yongzhou Hu
DOI:10.2174/09298673113209990122

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Piroxicam-β-Cyclodextrin: A GI Safer Piroxicam open Access plus

Volume: 20   Issue: 19
Pp: 2415-2437
C. Scarpignato
DOI:10.2174/09298673113209990115

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Insulin Secretion and Interleukin-1β Dependent Mechanisms in Human Diabetes Remission After Metabolic Surgery open Access plus

Volume: 20   Issue: 18
Pp: 2374-2388
Chih-Yen Chen, Wei-Jei Lee, A. Asakawa, N. Fujitsuka, Keong Chong, Shu-Chun Chen, Shou-Dong Lee and A. Inui
DOI:10.2174/0929867311320180008

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1,2,4-Oxadiazoles Identified by Virtual Screening and their Non-Covalent Inhibition of the Human 20S Proteasome open Access plus

Volume: 20   Issue: 18
Pp: 2351-2362
X. Maréchal, E. Genin, L. Qin, O. Sperandio, M. Montes, N. Basse, N. Richy, M.A. Miteva, M. Reboud-Ravaux, J. Vidal and B.O. Villoutreix
DOI:10.2174/0929867311320180006

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Luminescent Silica Nanoparticles for Cancer Diagnosis open Access plus

Volume: 20   Issue: 17
Pp: 2195-2211
W. Arap, R. Pasqualini, M. Montalti, L. Petrizza, L. Prodi, E. Rampazzo, N. Zaccheroni and S. Marchio
DOI:10.2174/0929867311320170005

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Computational Peptidology: A New and Promising Approach to Therapeutic Peptide Design open Access plus

Volume: 20   Issue: 15
Pp: 1985-1996
P. Zhou, C. Wang, Y. Ren, C. Yang and F. Tian
DOI:10.2174/0929867311320150005

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Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells open Access plus

Volume: 20   Issue: 15
Pp: 1923-1945
Giuliana Cassinelli, Valentina Zuco, Laura Gatti, Cinzia Lanzi, Nadia Zaffaroni, Diego Colombo and Paola Perego
DOI:10.2174/09298673113209990106

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Histone Deacetylase Inhibitors: An Attractive Strategy for Cancer Therapy open Access plus

Volume: 20   Issue: 14
Pp: 1858-1886
Jiyang Li, Guangqiang Li and Wenqing Xu
DOI:10.2174/0929867311320140005

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RNAi in Clinical Studies open Access plus

Volume: 20   Issue: 14
Pp: 1801-1816
P. Kubowicz, D. Zelaszczyk and E. Pekala
DOI:10.2174/09298673113209990118

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Multi-Target Compounds Acting in the Central Nervous System Designed From Natural Products open Access plus

Volume: 20   Issue: 13
Pp: 1673-1685
X. Chen and M. Decker
DOI:10.2174/0929867311320130007

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Rationally Designed Multi-Targeted Agents Against Neurodegenerative Diseases open Access plus

Volume: 20   Issue: 13
Pp: 1662-1672
W. J. Geldenhuys and C. J. Van der Schyf
DOI:10.2174/09298673113209990112

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The Economics of Polypharmacology: Fixed Dose Combinations and Drug Cocktails open Access plus

Volume: 20   Issue: 13
Pp: 1635-1638
A. I. Wertheimer
DOI:10.2174/0929867311320130003

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Camptothecin Resistance in Cancer: Insights into the Molecular Mechanisms of a DNA-Damaging Drug open Access plus

Volume: 20   Issue: 12
Pp: 1541-1565
G. L. Beretta, L. Gatti, P. Perego and N. Zaffaroni
DOI:10.2174/0929867311320120006

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Long-Acting Beta-Agonists and their Association with Inhaled Corticosteroids in COPD open Access plus

Volume: 20   Issue: 12
Pp: 1477-1495
L. Fuso, N. Mores, S. Valente, M. Malerba and P. Montuschi
DOI:10.2174/0929867311320120003

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Anti-Inflammatory and Antioxidant Effects of Resveratrol in Healthy Smokers A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial open Access plus

Volume: 20   Issue: 10
Pp: 1323-1331
S. Bo, G. Ciccone, A. Castiglione, R. Gambino, F. De Michieli, P. Villois, M. Durazzo, P. Cavallo-Perin and M. Cassader
DOI:10.2174/0929867311320100009

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Serenoa Repens, Lycopene and Selenium: A Triple Therapeutic Approach to Manage Benign Prostatic Hyperplasia open Access plus

Volume: 20   Issue: 10
Pp: 1306-1312
L. Minutoli, A. Bitto, F. Squadrito, H. Marini, N. Irrera, G. Morgia, A. Passantino and D. Altavilla
DOI:10.2174/0929867311320100007

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Ion Channels as Drug Targets in Central Nervous System Disorders open Access plus

Volume: 20   Issue: 10
Pp: 1241-1285
A. M. Waszkielewicz, A. Gunia, N. Szkaradek, K. Sloczynska, S. Krupinska and H. Marona
DOI:10.2174/0929867311320100005

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Plant Metabolomics: From Holistic Data to Relevant Biomarkers open Access plus

Volume: 20   Issue: 8
Pp: 1056-1090
Jean-Luc Wolfender, Serge Rudaz, Young Hae Choi and Hye Kyong Kim
DOI:10.2174/0929867311320080009

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From Resveratrol to Its Derivatives: New Sources of Natural Antioxidant open Access plus

Volume: 20   Issue: 8
Pp: 1005-1017
Shan He and Xiaojun Yan
DOI:10.2174/0929867311320080004

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Antimicrobial Plant Metabolites: Structural Diversity and Mechanism of Action open Access plus

Volume: 20   Issue: 7
Pp: 932-952
N.S. Radulovic, P.D. Blagojevic, Z.Z. Stojanovic-Radic and N.M. Stojanovic
DOI:10.2174/0929867311320070008

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The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications open Access plus

Volume: 20   Issue: 7
Pp: 908-931
A. Alqahtani, K. Hamid, A. Kam, K.H. Wong, Z. Abdelhak, V. Razmovski-Naumovski, K. Chan, K.M. Li, P.W. Groundwater and G.Q. Li
DOI:10.2174/0929867311320070007

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Survey of Recent Literature Related to the Biologically Active 4(3H)-Quinazolinones Containing Fused Heterocycles open Access plus

Volume: 20   Issue: 6
Pp: 794-814
Martine Demeunynck and Isabelle Baussanne
DOI:10.2174/0929867311320060006

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Glyconanoparticles-An Update open Access plus

Volume: 20   Issue: 6
Pp: 782-788
Gangliang Huang
DOI:10.2174/0929867311320060004

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Honey as a Source of Dietary Antioxidants: Structures, Bioavailability and Evidence of Protective Effects Against Human Chronic Diseases open Access plus

Volume: 20   Issue: 5
Pp: 621-638
Josè M. Alvarez-Suarez, Francesca Giampieri and Maurizio Battino
DOI:10.2174/092986713804999358

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