Abstract
Serotonin is a neuromediator, well-know for its implication in mood regulation, anxiety, depression and, insomnia as well as in normal human function such as sleep, sexual activity and appetite. In this way, serotonin (5-hydroxytryptamine, 5-HT) is one of the most attractive targets for medicinal chemists and pharmaceutical companies. Among 5-HTRs, the 5-HT1A subtype is the best studied, and it is generally accepted that it is involved in psychiatric disorders such as anxiety and depression. Several structurally different compounds are known to bind 5-HT1A receptor sites such as aminotetralins, ergolines, arylpiperazines, indolylalkylamines, aporphines and aryloxyalkyl-amines.
Keywords: serotonin, neurotransmitter, g protein-coupled receptors, median raphe nucleus (mrn), ohdpat, enantioselectivity, indolylalkylamines, ergolines, aporphines, qsar
Current Medicinal Chemistry
Title: Derivatives as 5HT1A Receptor Ligands-Past and Present
Volume: 12 Issue: 15
Author(s): G. Caliendo, V. Santagada, E. Perissutti and F. Fiorino
Affiliation:
Keywords: serotonin, neurotransmitter, g protein-coupled receptors, median raphe nucleus (mrn), ohdpat, enantioselectivity, indolylalkylamines, ergolines, aporphines, qsar
Abstract: Serotonin is a neuromediator, well-know for its implication in mood regulation, anxiety, depression and, insomnia as well as in normal human function such as sleep, sexual activity and appetite. In this way, serotonin (5-hydroxytryptamine, 5-HT) is one of the most attractive targets for medicinal chemists and pharmaceutical companies. Among 5-HTRs, the 5-HT1A subtype is the best studied, and it is generally accepted that it is involved in psychiatric disorders such as anxiety and depression. Several structurally different compounds are known to bind 5-HT1A receptor sites such as aminotetralins, ergolines, arylpiperazines, indolylalkylamines, aporphines and aryloxyalkyl-amines.
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Cite this article as:
Caliendo G., Santagada V., Perissutti E. and Fiorino F., Derivatives as 5HT1A Receptor Ligands-Past and Present, Current Medicinal Chemistry 2005; 12 (15) . https://dx.doi.org/10.2174/0929867054367220
DOI https://dx.doi.org/10.2174/0929867054367220 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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