Abstract
Tumor cells are not only susceptible to signals from the environment, but they likewise release signal substances. It is well known that tumor cells secrete angiogenic factors - most prominently the vascular endothelial growth factor - which initiate the vascularization of the tumor for its nourishment. This process has been termed neoangiogenesis. Besides this, two further processes have recently been discovered that facilitate the interaction of the tumor with the lymphatic system and the nervous system, named lymphangiogenesis and neoneurogenesis. These three “geneses” have a cognate, in part common regulation and conjointly promote metastasis development. Neoangiogenesis and lymphangiogenesis provide the structures for the two routes of tumor cell dissemination, i.e. either hematogenous or lymphatic. Neoneurogenesis accomplishes the innervation of the tumor by the ingrowth of nerve endings into the tumor and alternatively or additionally by the protection of existing nerve cells from destruction. These tumor-innervating nerve cells may release neurotransmitters which are proliferative or promigratory signals for the tumor cells. Furthermore, nerve fibers are used as routes for tumor cell dissemination, too, which is known as perineural invasion.
Keywords: Neoangiogenesis, lymphangiogenesis, neoneurogenesis, perineural invasion, metastasis formation
Current Pharmaceutical Design
Title: Connecting A Tumor to the Environment
Volume: 13 Issue: 33
Author(s): Frank Entschladen, Daniel Palm, Theodore L. Drell IV,, Kerstin Lang and Kurt S. Zaenker
Affiliation:
Keywords: Neoangiogenesis, lymphangiogenesis, neoneurogenesis, perineural invasion, metastasis formation
Abstract: Tumor cells are not only susceptible to signals from the environment, but they likewise release signal substances. It is well known that tumor cells secrete angiogenic factors - most prominently the vascular endothelial growth factor - which initiate the vascularization of the tumor for its nourishment. This process has been termed neoangiogenesis. Besides this, two further processes have recently been discovered that facilitate the interaction of the tumor with the lymphatic system and the nervous system, named lymphangiogenesis and neoneurogenesis. These three “geneses” have a cognate, in part common regulation and conjointly promote metastasis development. Neoangiogenesis and lymphangiogenesis provide the structures for the two routes of tumor cell dissemination, i.e. either hematogenous or lymphatic. Neoneurogenesis accomplishes the innervation of the tumor by the ingrowth of nerve endings into the tumor and alternatively or additionally by the protection of existing nerve cells from destruction. These tumor-innervating nerve cells may release neurotransmitters which are proliferative or promigratory signals for the tumor cells. Furthermore, nerve fibers are used as routes for tumor cell dissemination, too, which is known as perineural invasion.
Export Options
About this article
Cite this article as:
Entschladen Frank, Palm Daniel, Drell IV, L. Theodore, Lang Kerstin and Zaenker S. Kurt, Connecting A Tumor to the Environment, Current Pharmaceutical Design 2007; 13 (33) . https://dx.doi.org/10.2174/138161207782360573
DOI https://dx.doi.org/10.2174/138161207782360573 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
STAT3: A Potential Drug Target for Tumor and Inflammation
Current Topics in Medicinal Chemistry Efficacy and Safety of Antigen-specific Immunotherapy in the Treatment of Patients with Non-small-cell Lung Cancer: A Systematic Review and Meta-analysis
Current Cancer Drug Targets Molecular Dynamics in Esophageal Adenocarcinoma: Who’s in Control?
Current Cancer Drug Targets Coffea arabica Bean Extracts and Vitamin C: A Novel Combination Unleashes MCF-7 Cell Death
Current Pharmaceutical Biotechnology Recent Advances and Challenges in Adipose Tissue Engineering: Adipose Derived Stem Cell-based Approaches
Current Tissue Engineering (Discontinued) Four Major Factors Regulate Phosphatidylinositol 3-kinase Signaling Pathway in Cancers Induced by Infection of Human Papillomaviruses
Current Medicinal Chemistry Beam Commissioning Data Acquisition for the Iris Variable Aperture Collimator of CyberKnife VSI
Neuroscience and Biomedical Engineering (Discontinued) Cancer Stem Cell Model in Oral Squamous Cell Carcinoma
Current Stem Cell Research & Therapy Recent Patents Related to Phosphorylation Signaling Pathway on Cancer
Recent Patents on DNA & Gene Sequences Dual EGFR and COX-2 Inhibition as a Novel Approach to Targeting Head and Neck Squamous Cell Carcinoma
Current Cancer Drug Targets Hypoxic Regulation of Metastasis via Hypoxia-Inducible Factors
Current Molecular Medicine Targeting MET Receptor in Rhabdomyosarcoma: Rationale and Progress
Current Drug Targets Synthesis and Preliminary Cytotoxicity Studies of 1-[1-(4,5-Dihydrooxazol- 2-yl)-1H-indazol-3-yl]-3-phenylurea and 3-phenylthiourea Derivatives
Medicinal Chemistry Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents
Current Medicinal Chemistry Nampt/Visfatin/PBEF: A Functionally Multi-faceted Protein with a Pivotal Role in Malignant Tumors
Current Pharmaceutical Design VEGF Signal System: The Application of Antiangiogenesis
Current Medicinal Chemistry CSPG4 in Cancer: Multiple Roles
Current Molecular Medicine Vasotrophic Regulation of Age-Dependent Hypoxic Cerebrovascular Remodeling
Current Vascular Pharmacology Modulation of Anxiety Behavior by Intranasally Administered Vaccinia Virus Complement Control Protein and Curcumin in a Mouse Model of Alzheimers Disease
Current Alzheimer Research Neuropharmacological Mechanisms Underlying the Neuroprotective Effects of Methylphenidate
Current Neuropharmacology