Abstract
The lipid membrane is the portal to the cell and its first line of defense against the outside world. Its plasticity, diversity and powers of accommodation in a myriad of environments, mirrored by the varied make up of the cells it protects, are unparalleled. Glycerophospholipids are one of its major components. In cell membranes the extracellular layer is mainly made up of positively charged glycolipids, while the intracellular ones main components are negatively charged. Advances in mass spectrometry have allowed the direct probing of tissues, and thus a direct approach to probing membranes make up was developed. Until recently most studies have focused on proteins. An overview of the use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) for the direct analysis of phospholipids in various tissue is presented. Molecular ions corresponding to phosphatidylcholines, sphingomyelin, phosphatidylethanolamines, phosphatidylserines, phosphatidylinositols and sulfatides were mapped.
Keywords: phosphocholine head group, phosphatidylethanolamines, fragment peaks, MALDI, Lipid
Current Pharmaceutical Design
Title: A Snapshot of Tissue Glycerolipids
Volume: 13 Issue: 32
Author(s): Amina S. Woods, Hay-Yan J. Wang and Shelley N. Jackson
Affiliation:
Keywords: phosphocholine head group, phosphatidylethanolamines, fragment peaks, MALDI, Lipid
Abstract: The lipid membrane is the portal to the cell and its first line of defense against the outside world. Its plasticity, diversity and powers of accommodation in a myriad of environments, mirrored by the varied make up of the cells it protects, are unparalleled. Glycerophospholipids are one of its major components. In cell membranes the extracellular layer is mainly made up of positively charged glycolipids, while the intracellular ones main components are negatively charged. Advances in mass spectrometry have allowed the direct probing of tissues, and thus a direct approach to probing membranes make up was developed. Until recently most studies have focused on proteins. An overview of the use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) for the direct analysis of phospholipids in various tissue is presented. Molecular ions corresponding to phosphatidylcholines, sphingomyelin, phosphatidylethanolamines, phosphatidylserines, phosphatidylinositols and sulfatides were mapped.
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Cite this article as:
Woods S. Amina, Wang J. Hay-Yan and Jackson N. Shelley, A Snapshot of Tissue Glycerolipids, Current Pharmaceutical Design 2007; 13 (32) . https://dx.doi.org/10.2174/138161207782360636
DOI https://dx.doi.org/10.2174/138161207782360636 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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