Abstract
Recent findings from several groups demonstrate that ABC-A1 participates in the pathogenesis of the metabolic syndrome and type 2 diabetes. A variant of the ABC-A1 gene (R230C) is associated with the metabolic syndrome and its co-morbidities in Mexicans. Its presence is associated with an increased risk for obesity, the metabolic syndrome and type 2 diabetes. R230C is found exclusively in Amerindian and Amerindian-derived populations. Moreover, animal models confirm the participation of ABC-A1 in the pathogenesis of diabetes. Mice lacking AbcA1 specifically in beta cells had glucose intolerance at 8 weeks of age. The absence of ABC-A1 led to cholesterol accumulation within the beta cell plasma membrane, suggesting that cholesterol may play a role in the insulin secretory pathway. In conclusion, ABC-A1 may be more than a determinant of HDL-cholesterol. It may provide a link between components of the metabolic syndrome and atherosclerosis.
Keywords: ABC A1, Metabolic syndrome, Mexico, Abdominal obesity, LXR
Current Diabetes Reviews
Title: The ATP-Binding Cassette Transporter Subfamily A Member 1 (ABC-A1) and Type 2 Diabetes: An Association Beyond HDL Cholesterol
Volume: 3 Issue: 4
Author(s): Carlos A. Aguilar Salinas, Ivette Cruz-Bautista, Roopa Mehta, Ma T. Villarreal-Molina, Francisco J. G. Perez, Ma T. Tusie-Luna and Samuel Canizales-Quinteros
Affiliation:
Keywords: ABC A1, Metabolic syndrome, Mexico, Abdominal obesity, LXR
Abstract: Recent findings from several groups demonstrate that ABC-A1 participates in the pathogenesis of the metabolic syndrome and type 2 diabetes. A variant of the ABC-A1 gene (R230C) is associated with the metabolic syndrome and its co-morbidities in Mexicans. Its presence is associated with an increased risk for obesity, the metabolic syndrome and type 2 diabetes. R230C is found exclusively in Amerindian and Amerindian-derived populations. Moreover, animal models confirm the participation of ABC-A1 in the pathogenesis of diabetes. Mice lacking AbcA1 specifically in beta cells had glucose intolerance at 8 weeks of age. The absence of ABC-A1 led to cholesterol accumulation within the beta cell plasma membrane, suggesting that cholesterol may play a role in the insulin secretory pathway. In conclusion, ABC-A1 may be more than a determinant of HDL-cholesterol. It may provide a link between components of the metabolic syndrome and atherosclerosis.
Export Options
About this article
Cite this article as:
Aguilar Salinas A. Carlos, Cruz-Bautista Ivette, Mehta Roopa, Villarreal-Molina T. Ma, Perez J. G. Francisco, Tusie-Luna T. Ma and Canizales-Quinteros Samuel, The ATP-Binding Cassette Transporter Subfamily A Member 1 (ABC-A1) and Type 2 Diabetes: An Association Beyond HDL Cholesterol, Current Diabetes Reviews 2007; 3 (4) . https://dx.doi.org/10.2174/157339907782329979
DOI https://dx.doi.org/10.2174/157339907782329979 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Effects of Aerobic Exercise and Training on Coagulation, Platelet Aggregation, and Plasma Lipids
Vascular Disease Prevention (Discontinued) Mechanisms for Progenitor Cell-Mediated Repair for Ischemic Heart Injury
Current Stem Cell Research & Therapy Diagnostic and Therapeutic Nanoparticles in Cardiovascular Diseases
Current Pharmaceutical Design New Strategies for Managing Anemia of Chronic Kidney Disease
Cardiovascular & Hematological Agents in Medicinal Chemistry The cAMP-Dependent Protein Kinase Pathway as Therapeutic Target – Possibilities and Pitfalls
Current Topics in Medicinal Chemistry CRISPR-cas System as a Genome Engineering Platform: Applications in Biomedicine and Biotechnology
Current Gene Therapy High-Density Lipoprotein and Low-Density Lipoprotein Subfractions in Patients with Chronic Kidney Disease
Current Vascular Pharmacology Narcolepsy in Adolescents: A Review and Three Case Reports
Adolescent Psychiatry Study of Parasitic Infections, Cancer, and other Diseases with Mass-Spectrometry and Quantitative Proteome-Disease Relationships
Current Proteomics When Does Food Refusal Require Professional Intervention?
Current Nutrition & Food Science Application of Hematopoietic Cells to Therapeutic Angiogenesis
Current Pharmaceutical Design Present Drug Therapy of Demyelinating Disorders
Current Drug Therapy The Anti-Inflammatory Effects of Statins on Coronary Artery Disease: An Updated Review of the Literature
Current Cardiology Reviews Mitochondria-Targeted Drugs
Current Molecular Pharmacology Is Glyburide Safe in Pregnancy?
Current Pharmaceutical Biotechnology A Review of Cardiogenic Shock in Acute Myocardial Infarction
Current Cardiology Reviews The Role of Adipokines in Hypertension and Cardiovascular Disease
Current Hypertension Reviews Resistin and Oxidative Stress in Non-Diabetic Obstructive Sleep Apnea Patients with Nocturnal Hypertension
Current Respiratory Medicine Reviews Modified Polysaccharides as Versatile Materials in Controlled Delivery of Antidegenerative Agents
Current Pharmaceutical Design microRNA in Chondrogenesis, Cartilage and Osteoarthritis
Current Rheumatology Reviews