Abstract
Selective accumulation of an exogenous enzyme or activating agent at a target cell allows use of prodrugs that will be unmasked only at this site. This can reduce the side effects of chemotherapy and allow more potent drugs to be used in various treatments. Examples of this two-step prodrug therapy include antibody- (ADEPT, ADAPT), genetic- (GDEPT, VDEPT) and macromolecule-based approaches (PDEPT, LEAPT). Carbohydrate chemistry and glycobiology feature in each of these areas and is the focus of this review.
Keywords: Abzymes, antibodies, asialoglycoprotein receptor, daunorubicin, doxorubicin, glycoconjugates, glycosidases, HPMA, prodrugs
Current Drug Delivery
Title: Painting the Target Around the Arrow: Two-Step Prodrug Therapies from a Carbohydrate Chemists Perspective
Volume: 4 Issue: 4
Author(s): Todd A. Houston
Affiliation:
Keywords: Abzymes, antibodies, asialoglycoprotein receptor, daunorubicin, doxorubicin, glycoconjugates, glycosidases, HPMA, prodrugs
Abstract: Selective accumulation of an exogenous enzyme or activating agent at a target cell allows use of prodrugs that will be unmasked only at this site. This can reduce the side effects of chemotherapy and allow more potent drugs to be used in various treatments. Examples of this two-step prodrug therapy include antibody- (ADEPT, ADAPT), genetic- (GDEPT, VDEPT) and macromolecule-based approaches (PDEPT, LEAPT). Carbohydrate chemistry and glycobiology feature in each of these areas and is the focus of this review.
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Cite this article as:
Houston A. Todd, Painting the Target Around the Arrow: Two-Step Prodrug Therapies from a Carbohydrate Chemists Perspective, Current Drug Delivery 2007; 4 (4) . https://dx.doi.org/10.2174/156720107782151278
DOI https://dx.doi.org/10.2174/156720107782151278 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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