Abstract
Recent advances in electrochemical detection techniques coupled with high-performance liquid chromatography (HPLC-ECD) in pharmaceutical and biomedical analysis are reviewed. ECD classification and modes including common amperometric, coulometric, conductimetric, and potentiometric detector, are outlined and the some typical examples of determinations in pharmaceutical and biomedical analysis are described. The electrochemical detection system can offer superior merits over other detectors commonly used with HPLC. These techniques have great potential owing to their prominent characteristics in high-throughput screening procedures of drugs in various matrices. Fundamental 67 references from last 5 years related with a field are cited in this review.
Keywords: HPLC, electrochemical detector, pharmaceutical analysis, drug screening
Combinatorial Chemistry & High Throughput Screening
Title: Electrochemical Detection Coupled with High-Performance Liquid Chromatography in Pharmaceutical and Biomedical Analysis: A Mini Review
Volume: 10 Issue: 7
Author(s): Chengyin Wang, Jianyun Xu, Guiyou Zhou, Qishu Qu, Gongjun Yang and Xiaoya Hu
Affiliation:
Keywords: HPLC, electrochemical detector, pharmaceutical analysis, drug screening
Abstract: Recent advances in electrochemical detection techniques coupled with high-performance liquid chromatography (HPLC-ECD) in pharmaceutical and biomedical analysis are reviewed. ECD classification and modes including common amperometric, coulometric, conductimetric, and potentiometric detector, are outlined and the some typical examples of determinations in pharmaceutical and biomedical analysis are described. The electrochemical detection system can offer superior merits over other detectors commonly used with HPLC. These techniques have great potential owing to their prominent characteristics in high-throughput screening procedures of drugs in various matrices. Fundamental 67 references from last 5 years related with a field are cited in this review.
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Cite this article as:
Wang Chengyin, Xu Jianyun, Zhou Guiyou, Qu Qishu, Yang Gongjun and Hu Xiaoya, Electrochemical Detection Coupled with High-Performance Liquid Chromatography in Pharmaceutical and Biomedical Analysis: A Mini Review, Combinatorial Chemistry & High Throughput Screening 2007; 10 (7) . https://dx.doi.org/10.2174/138620707782152362
DOI https://dx.doi.org/10.2174/138620707782152362 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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