Abstract
Environmental toxicants comprise a number of man-made organic chemicals which may resist metabolism or their metabolites may persist in the environment and accumulate in the food chain. Some of these persistent chemicals are carried over long distances via the atmospheric transport and can have biological effects in fish, wildlife and humans. In this review the relationship between structure of these chemicals, their mode of action and their possible roles in adverse developmental and reproductive processes in humans will be discussed. The focus will be on model polychlorinated biphenyls and dioxins, organochlorines, phthalates, a constituent of cigarette smoke (benzo-a-pyrene), synthetic polymers (polybrominated diphenyl ethers and polyfluorinated compounds), and a fungicide (vinclozolin).
Keywords: Pesticides, ovary, testes, receptors, membranes, fertility, steroids, epigenetics
Current Pharmaceutical Design
Title: Reproductive Toxicology of Environmental Toxicants: Emerging Issues and Concerns
Volume: 13 Issue: 29
Author(s): E. V. Younglai, Y. J . Wu and W. G. Foster
Affiliation:
Keywords: Pesticides, ovary, testes, receptors, membranes, fertility, steroids, epigenetics
Abstract: Environmental toxicants comprise a number of man-made organic chemicals which may resist metabolism or their metabolites may persist in the environment and accumulate in the food chain. Some of these persistent chemicals are carried over long distances via the atmospheric transport and can have biological effects in fish, wildlife and humans. In this review the relationship between structure of these chemicals, their mode of action and their possible roles in adverse developmental and reproductive processes in humans will be discussed. The focus will be on model polychlorinated biphenyls and dioxins, organochlorines, phthalates, a constituent of cigarette smoke (benzo-a-pyrene), synthetic polymers (polybrominated diphenyl ethers and polyfluorinated compounds), and a fungicide (vinclozolin).
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Cite this article as:
Younglai V. E., Wu J . Y. and Foster G. W., Reproductive Toxicology of Environmental Toxicants: Emerging Issues and Concerns, Current Pharmaceutical Design 2007; 13 (29) . https://dx.doi.org/10.2174/138161207782110499
DOI https://dx.doi.org/10.2174/138161207782110499 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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