Abstract
Up to date, it has been reported that several bioactive natural compounds can modulate bone metabolism. It has been also disclosed that some of them simultaneously modulate the immune response. Thus, understanding the molecular mechanisms surrounding bone metabolism has moved bone research into a new era and recently the term “osteoimmunology” is coined to describe new interdisciplinary field of bone and immunology. Now, therefore bone research is one of the hot spots designing novel drugs. Notably, the role of phytoestrogens represented by isoflavones in the bone health was frequently reviewed; however only a few reviews thoroughly cover the field of bioactive natural compounds in bone metabolism. In this review, we summarize current status of representative bioactive natural compounds that modulate bone metabolism and present new therapeutic approaches in the near future by focusing on three classes of compounds phytoestrogens, polyunsaturated fatty acids and lactoferrin.
Keywords: Osteoporosis, bone, natural compounds, phytoestrogens, isoflavones, polyunsaturated fatty acids, omega-3, lactoferrin
Current Bioactive Compounds
Title: Bone Modulating Bioactive Natural Compounds: Review
Volume: 3 Issue: 3
Author(s): Kanji Mori, Dominique Heymann and Ronan Le Bot
Affiliation:
Keywords: Osteoporosis, bone, natural compounds, phytoestrogens, isoflavones, polyunsaturated fatty acids, omega-3, lactoferrin
Abstract: Up to date, it has been reported that several bioactive natural compounds can modulate bone metabolism. It has been also disclosed that some of them simultaneously modulate the immune response. Thus, understanding the molecular mechanisms surrounding bone metabolism has moved bone research into a new era and recently the term “osteoimmunology” is coined to describe new interdisciplinary field of bone and immunology. Now, therefore bone research is one of the hot spots designing novel drugs. Notably, the role of phytoestrogens represented by isoflavones in the bone health was frequently reviewed; however only a few reviews thoroughly cover the field of bioactive natural compounds in bone metabolism. In this review, we summarize current status of representative bioactive natural compounds that modulate bone metabolism and present new therapeutic approaches in the near future by focusing on three classes of compounds phytoestrogens, polyunsaturated fatty acids and lactoferrin.
Export Options
About this article
Cite this article as:
Mori Kanji, Heymann Dominique and Bot Le Ronan, Bone Modulating Bioactive Natural Compounds: Review, Current Bioactive Compounds 2007; 3 (3) . https://dx.doi.org/10.2174/157340707781695613
DOI https://dx.doi.org/10.2174/157340707781695613 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Oxidative Stress and its Clinical Consequences: Relationship between Diabetes and Cancer
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry HIV Compartmentalization: A Review on a Clinically Important Phenomenon
Current HIV Research Glioma: Tryptophan Catabolite and Melatoninergic Pathways Link microRNA, 14-3- 3, Chromosome 4q35, Epigenetic Processes and other Glioma Biochemical Changes
Current Pharmaceutical Design miR-143: A Novel Regulator of MyoD Expression in Fast and Slow Muscles of Siniperca chuatsi
Current Molecular Medicine Molecular Targets and Targeted Therapies for Malignant Mesothelioma
Current Medicinal Chemistry Role of Unani Medicines in Cancer Control and Management
Current Drug Therapy An Update on Developments in Female Hormonal Contraception
Current Women`s Health Reviews Cancer Biomarker Discovery for Precision Medicine: New Progress
Current Medicinal Chemistry Depot Based Drug Delivery System for the Management of Depression
Current Drug Delivery Quantitative Structure-Activity Relationship Studies: Understanding the Mechanism of Tyrosine Kinase Inhibition
Current Enzyme Inhibition Inhibitory Smad7: Emerging Roles in Health and Disease
Current Molecular Pharmacology The Role of Estrogen and Estrogen-Related Drugs in Cardiovascular Diseases
Current Drug Metabolism Personalizing HER2-Targeted Therapy in Metastatic Breast Cancer Beyond HER2 Status: What We Have Learned from Clinical Specimens
Current Pharmacogenomics and Personalized Medicine RNAi in Clinical Studies
Current Medicinal Chemistry The Role of Diabetes in Molecular Pathogenesis of Cancer
Current Signal Transduction Therapy Cancer Chemoprevention by Targeting the Epigenome
Current Drug Targets Microfilament Actin Remodeling as a Potential Target for Cancer Drug Development
Current Cancer Drug Targets Meet the Editorial Board:
Current Drug Targets Cancer Vaccines for Hormone/Growth Factor Immune Deprivation:A Feasible Approach for Cancer Treatment
Current Cancer Drug Targets The Targets of Curcumin
Current Drug Targets