Abstract
Natriuretic peptides (NPs) are endogenous low molecular weight peptides known for their hypotensive activities. Due to their ability to induce both natriuresis (Na+ secretion) and diuresis, in fact, these peptides can profoundly decrease the body haemodynamic load, an effect which represents a main goal for all therapies aiming at improving the health of those subjects affected by different forms of heart and kidney failure. Over the years, many evidences have been provided for the involvement of NPs in the control of different cardiovascular parameters both in physiological and pathological conditions. This has led many researchers to test the possible therapeutic effects of different NPs and the pharmacological industries to develop exogenous NPs forms with a higher activity. This review aims then at summarizing the current knowledge about the therapeutic and clinical applications of NPs, also considering “atypical” NPs and the problems yet to be solved.
Keywords: C-type Natriuretic Peptide, NPPB gene, congestive heart failure, neutral endopeptidase 24.11, Dendroaspis Natriuretic Peptide
Current Pharmaceutical Analysis
Title: Pharmacological and Clinical Applications of Natriuretic Peptides: Accepted Knowledges or Changing Views?
Volume: 3 Issue: 3
Author(s): Izzi Valerio, Chiurchiu Valerio and Baldini P. Morena
Affiliation:
Keywords: C-type Natriuretic Peptide, NPPB gene, congestive heart failure, neutral endopeptidase 24.11, Dendroaspis Natriuretic Peptide
Abstract: Natriuretic peptides (NPs) are endogenous low molecular weight peptides known for their hypotensive activities. Due to their ability to induce both natriuresis (Na+ secretion) and diuresis, in fact, these peptides can profoundly decrease the body haemodynamic load, an effect which represents a main goal for all therapies aiming at improving the health of those subjects affected by different forms of heart and kidney failure. Over the years, many evidences have been provided for the involvement of NPs in the control of different cardiovascular parameters both in physiological and pathological conditions. This has led many researchers to test the possible therapeutic effects of different NPs and the pharmacological industries to develop exogenous NPs forms with a higher activity. This review aims then at summarizing the current knowledge about the therapeutic and clinical applications of NPs, also considering “atypical” NPs and the problems yet to be solved.
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Izzi Valerio , Chiurchiu Valerio and Baldini P. Morena , Pharmacological and Clinical Applications of Natriuretic Peptides: Accepted Knowledges or Changing Views?, Current Pharmaceutical Analysis 2007; 3 (3) . https://dx.doi.org/10.2174/157341207781369376
DOI https://dx.doi.org/10.2174/157341207781369376 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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