Abstract
Malignant cells are characterized by alterations in multiple signaling pathways that promote proliferation, inhibit apoptosis, promote angiogenesis in the case of solid tumors, and enable cancer cells to invade and migrate through tissues. A variety of foods and their bioactive dietary constituents appear to have merit in reducing cancer risk and modifying tumor behavior. All of the major signaling pathways, which are deregulated in cancer, and which serve as potential targets for cancer prevention, have been reported to respond to one or more dietary components. Herein, we provide a brief overview of the importance of diet as a modifier of carcinogen metabolism, DNA repair, cell proliferation, apoptosis, inflammation, immunity, differentiation, angiogenesis, hormonal regulation and cellular energetics. This special issue of Current Cancer Drug Targets provides a collection of articles from researchers who are actively involved in examining the role of dietary components in cancer prevention and therapy. The remaining articles in this series provide more details about the specifics about the importance of these processes during carcinogenesis and proof-of-principal about the modifying capabilities of food patterns, specific foods and individual bioactive food components.
Keywords: Molecular targets, cancer prevention, nutrigenomics, bioactive food components
Current Cancer Drug Targets
Title: Molecular Targets for Nutritional Preemption of Cancer
Volume: 7 Issue: 5
Author(s): Cindy D. Davis and John A. Milner
Affiliation:
Keywords: Molecular targets, cancer prevention, nutrigenomics, bioactive food components
Abstract: Malignant cells are characterized by alterations in multiple signaling pathways that promote proliferation, inhibit apoptosis, promote angiogenesis in the case of solid tumors, and enable cancer cells to invade and migrate through tissues. A variety of foods and their bioactive dietary constituents appear to have merit in reducing cancer risk and modifying tumor behavior. All of the major signaling pathways, which are deregulated in cancer, and which serve as potential targets for cancer prevention, have been reported to respond to one or more dietary components. Herein, we provide a brief overview of the importance of diet as a modifier of carcinogen metabolism, DNA repair, cell proliferation, apoptosis, inflammation, immunity, differentiation, angiogenesis, hormonal regulation and cellular energetics. This special issue of Current Cancer Drug Targets provides a collection of articles from researchers who are actively involved in examining the role of dietary components in cancer prevention and therapy. The remaining articles in this series provide more details about the specifics about the importance of these processes during carcinogenesis and proof-of-principal about the modifying capabilities of food patterns, specific foods and individual bioactive food components.
Export Options
About this article
Cite this article as:
Cindy D. Davis and John A. Milner , Molecular Targets for Nutritional Preemption of Cancer, Current Cancer Drug Targets 2007; 7 (5) . https://dx.doi.org/10.2174/156800907781386560
DOI https://dx.doi.org/10.2174/156800907781386560 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
Call for Papers in Thematic Issues
Advances in Cancer Biomarkers and Potential Drug Targets: From Diagnosis to Therapy
Cancer biomarkers play a crucial role in the diagnosis, prognosis, and treatment of cancer. They provide valuable information for cancer detection, risk assessment, treatment selection, and monitoring response to therapy. With advancements in molecular biology and high-throughput technologies, there has been an increasing interest in identifying and characterizing cancer biomarkers ...read more
Novel Therapeutic Approaches to Target Drug Resistant Tumors
With the development of disciplines such as chemical biology and molecular biology, the genes or proteins closely related to tumor occurrence and development have gradually become clear. Targeted therapies targeting these genes or proteins provide more effective methods for tumor treatment. Tumor targeted drugs generally only act on specific targets ...read more
ROLE OF IMMUNE AND GENOTOXIC RESPONSE BIOMARKERS IN TUMOR MICROENVIRONMENT IN CANCER DIAGNOSIS AND TREATMENT
Biological biomarkers have been used in medical research as an indicator of a normal or abnormal process inside the body, or of a disease. Nowadays, various researchers are in process to explore and investigate the biological markers for the early assessment of cancer. DNA Damage response (DDR) pathways and immune ...read more
Targeting the battlefield between host and tumor: basic research and clinical practice on reshaping tumor immune microenvironment
Immune system protects host against malignant tumors through effector cells and molecules. Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses cancer progression. Chronic inflammation facilitates cancer progression and treatment resistance, whereas induction of acute inflammatory reactions often lead to anti-cancer immune responses. ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications
Current Cancer Drug Targets Inhibition of Transcription Factors by Plant-Derived Compounds and their Implications in Inflammation and Cancer
Current Pharmaceutical Design Alam K et al. (2018) Drug Metabolism Letters; 12, 24-32.
Drug Metabolism Letters Antisense Targets to Enhance Hormone and Cytotoxic Therapies in Advanced Prostate Cancer
Current Drug Targets Active Surveillance for Prostate Cancer and Small Renal Masses: New Evidences and Criticisms
Anti-Cancer Agents in Medicinal Chemistry Editorial [Hot Topic: Therapeutic Application of Melanocortin-4 Receptor Ligands (Guest Editor: John P. Mayer)]
Current Topics in Medicinal Chemistry Herbal Phytochemicals as Immunomodulators
Current Immunology Reviews (Discontinued) From Biomarkers to Cytokine-like Hormones: Uncovering New Directives for Cognitive Loss and Alzheimer’s Disease
Current Neurovascular Research Literature Review: Use of Family History for Primary Paediatric Care as the Next Step Towards use of Genomics in Healthcare
Current Pediatric Reviews Molecular Modeling Used to Evaluate CYP2C9-Dependent Metabolism: Homology Modeling, Molecular Dynamics and Docking Simulations
Current Drug Metabolism In vivo Radiosensitization of Human Glioma U87 Cells Induced by Upregulated Expression of DUSP-2 after Treatment with Curcumin
Current Signal Transduction Therapy Oridonin, a Promising Antitumor Natural Product in the Chemotherapy of Hematological Malignancies
Current Pharmaceutical Biotechnology Disorder in Milk Proteins: Formation, Structure, Function, Isolation and Applications of Casein Phosphopeptides
Current Protein & Peptide Science Anti-Tumor Activity of Non-Nucleosidic Reverse Transcriptase Inhibitors
Current Pharmaceutical Design Pharmacokinetic and Toxicological Characteristics of Tripterigium Glycosides and Their Derivatives
Current Drug Metabolism Recent Patents on Biomedical Devices and Nanomaterials for Hyperthermal Therapy of Cancer
Recent Patents on Nanomedicine The Recent Progresses on The Improved Therapy of Melanoma by Novel Drug Delivery Systems
Current Drug Targets An overview of ABC and SLC Drug Transporter Gene Regulation
Current Drug Metabolism Natural Sourced Inhibitors of EGFR, PDGFR, FGFR and VEGFRMediated Signaling Pathways as Potential Anticancer Agents
Current Medicinal Chemistry Active-Targeted Nanotherapy Strategies for Prostate Cancer
Current Cancer Drug Targets