ISSN (Print): 1573-403X
ISSN (Online): 1875-6557
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ISSN (Print): 1573-403X
ISSN (Online): 1875-6557
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Jian'an Wang School of Medicine Zhejiang University Hangzhou China
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"Current Cardiology Reviews is an important review journal, which is essential reading in order to be kept informed and up-to-date with the latest development in the field."
Univ. of Leuven, Belgium
(University of Leeds - Leeds Institute of Cardiovascular and Metabolic Medicine Leeds, United Kingdom.)
Has contributed: “Assessing Coronary Blood Flow Physiology in the Cardiac Catheterisation Laboratory.”:
Aging is a growing medical concern. Despite more people living longer, the economical impact is likely to be severe, and
pressures on healthcare providers are constantly growing to treat aging-related conditions and disorders. It is estimated, that in
the US, life expectancy will go from ~76 years of age in 2010 to 80 years in 2030 , a pattern that is similar to a host of industrialised
countries. Indeed, in the United Kingdom, recent analysis has shown that male life expectancy has increased from 69
years in 1970 to 78 years in 2010, and female life expectancy from 75 years to 82 years in the same time period . As a result,
incidence of aging-related diseases such as Cardiovascular Disease (CVD), dementia, and cancer is likely to increase substantially
. It is no surprise, therefore, that research into medical advancements and lifestyle behaviours and the impact of these
on aging populations has gathered a lot of interest in the academic community, as seen by the Physiological Society announcing
a year of ‘Understanding Ageing’ in 2015. This has led to the growth of research in aging, and also specifically cardiovascular
Lifestyle choices can have significant influence on how our cardiovascular system ages. We see individuals who are fitter
and regularly exercise, live longer than unfit/sedentary individuals [4, 5], which could be due to changes in our cardiovascular
system. Such favourable changes in our cardiovascular system with simple modifications in our lifestyle thus offers a significant
promise in helping to counteract the impact of aging on our bodies. This small collection of reviews, encompasses the effects
of diet, exercise and physical activity on the ‘aging cardiovascular system’, and provides some novel insights into the
mechanisms by which these affect our vascular and cardiac tissues.
The first review  puts forward the argument that resistance exercise could affect vascular aging via modulation of arterial
stiffness and Matrix Metalloproteinases (MMP). Older individuals display elevated levels of arterial stiffness (as measured by
pulse wave technology) compared to younger individuals , with recent evidence supporting the view that exercise can reduce
arterial stiffness in humans . Dr. Knox demonstrates some data to suggest that arterial remodelling with exercise may be a
result of altered MMP regulation, but more work is needed to observe this link in humans.
The second review  discusses the role of aging on the body’s endogenous endothelial repair capacity, via the reduction
and dysfunction of endothelial progenitor cells, and how exercise and dietary behaviour modulate both the number and function
of these cells. The effects vary from improving bone marrow niche environment and pro-apoptotic stimuli to promoting our
own stem/progenitor cell repair mechanisms on our ageing vasculature.
The subsequent review by Beaumont et al.  uses masters athlete’s as a model of lifelong exercisers, and the differences
in cardiac structure and function between master’s athlete’s and inactive older people. We observe that masters athletes display
better diastolic function than sedentary age-matched controls, which appears to be maintained into the 8th decade of life. Interestingly,
the review does not demonstrate much evidence on differences in systolic function, and a much debated measure of
systolic function, ejection fraction, does not appear to be different between sedentary controls and masters athletes, being suggestive
that lifelong exercise does not improve cardiac health via modulations in ejection fraction.
The final review in our collection, by Peace et al. , provides an insight into carotid and coronary arterial function, with
subsequent focus on the role of advancing age on both, and the potential for exercise to act as a countermeasure for the agingassociated
deleterious effects. They also purport that, since coronary artery function is difficult and incredibly invasive to
measure and quantify, that we can use carotid artery function as a surrogate, as it appears to show similar structural and functional
changes with disease conditions, offering clinicians and researchers a non-invasive global measure of arterial function
that could be used to determine risk of myocardial infarction, stroke, and other atherosclerotic-mediated events.
Together, these reviews provide evidence for the importance of lifestyle modifications and behaviour change to treat ageassociated
cardiovascular problems, which could subsequently have significant effects on healthcare burden and quality of life
of patients. However, translation of such work into practice is often poor at best, and thus strategies must be put into place by
governing bodies, healthcare providers, and clinicians to encompass such lifestyle strategies to treat disease.
In this issue of Current Cardiology Reviews, a mini-thematic review of the important role of Interventional Cardiology and
the cardiac cath lab in the management of cardiac arrest has been presented. Cardiac arrest is becoming an ever important topic
for multiple reasons. Science is expanding regarding cardiac arrest, which includes the understanding of the processes involved,
the appropriate use of new techniques and innovative devices in the management of these patients. The role of Interventional
Cardiologists in the management of these patients is also expanding. Thus this mini-thematic review summarizes how
Interventional Cardiologists and the Catheterization laboratory can have a major impact in improving the care of these patients,
ultimately increasing the survival of those suffering cardiac arrest.
In this review, Rao P and Kern KB have outlined ways in which communities can improve their local outcomes from out of hospital
cardiac arrest . Articles by Reddy S, Lee K, Kumar K and Lotun K have outlined the management of cardiac arrest
patients with both ST elevation and Non ST elevation myocardial infarction [2, 3]. No review on cardiac arrest patients is complete
without addressing post resuscitation care with targeted temperature control and addressing arrhythmias. Taimoor H and
Shetty R have reviewed the current guidelines of targeted temperature management . Prakash G and Hutchinson M have
addressed the management of arrhythmias and defibrillator implantation in the survivors of cardiac arrest . There is ample
positive data regarding immediate cardiac catheterization of cardiac arrest patients with ST Elevation myocardial infarction.
The Pearl Trial is underway to define the optimal management of cardiac arrest patients with non ST elevation myocardial.
Yadav K and Truong T have reviewed the important considerations for patients who have cardiac arrest while undergoing cardiac
procedures in the catheterization laboratory. Sundaram and Lotun have addressed the issue of refractory out of hospital
cardiac arrest especially the use of mechanical CPR devices and Extracorporeal Cardiopulmonary Resuscitation (ECPR) .
They have summarized a potential new approach for these patients, by mechanical support and performing coronary intervention
This mini-thematic review provides a comprehensive overview of the perspective of Interventional Cardiologists in the
management of cardiac arrest patient’s along with the post resuscitation management.