Current Drug Metabolism

Michael Sinz
Bristol Myers Squibb
Wallingford, CT
USA

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Open Access Articles

Digestive Enzyme Supplementation in Gastrointestinal Diseases open Access plus

Volume: 17   Issue: 2
Pp: 187-193
Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota
DOI:10.2174/138920021702160114150137

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Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines open Access plus

Volume: 16   Issue: 6
Pp: 412-426
Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti
DOI:10.2174/1389200216888150915112039

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Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide open Access plus

Volume: 15   Issue: 10
Pp: 953-965
Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum
DOI:10.2174/1389200216666150206124424

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A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics? open Access plus

Volume: 15   Issue: 6
Pp: 581-598
Lorena Baietto, Silvia Corcione, Giovanni Pacini, Giovanni Di Perri, Antonio D’Avolio and Francesco Giuseppe De Rosa
DOI:10.2174/1389200215666140605130935

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Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process open Access plus

Volume: 15   Issue: 2
Pp: 209-217
Kelly E. Caudle, Teri E. Klein, James M. Hoffman, Daniel J. Muller, Michelle Whirl-Carrillo, Li Gong, Ellen M. McDonagh, Katrin Sangkuhl, Caroline F. Thorn, Matthias Schwab, Jose A.G. Agundez, Robert R. Freimuth, Vojtech Huser, Ming Ta Michael Lee, Otito F. Iwuchukwu, Kristine R. Crews, Stuart A. Scott, Mia Wadelius, Jesse J. Swen, Rachel F. Tyndale, C. Michael Stein, Dan Roden, Mary V. Relling, Marc S. Williams and Samuel G. Johnson
DOI:10.2174/1389200215666140130124910

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Prodrugs of Quercetin and Resveratrol: A Strategy Under Development open Access plus

Volume: 15   Issue: 1
Pp: 77-95
Lucia Biasutto and Mario Zoratti
DOI:10.2174/1389200214666131211160005

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Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily open Access plus

Volume: 14   Issue: 10
Pp: 1059-1069
Tomas Smutny, Sridhar Mani and Petr Pavek
DOI:10.2174/1389200214666131211153307

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Pathways for Ligand Activated Nuclear Receptors to Unravel the Genomic Responses Induced by Hepatotoxicants open Access plus

Volume: 14   Issue: 10
Pp: 1022-1028
R.R.R. Fijten, D.G.J. Jennen and J.H.M. van Delft
DOI:10.2174/1389200214666131118234138

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Hepatic Cell Lines for Drug Hepatotoxicity Testing: Limitations and Strategies to Upgrade their Metabolic Competence by Gene Engineering open Access plus

Volume: 14   Issue: 9
Pp: 946-968
M. Teresa Donato, Ramiro Jover and M. José Gómez-Lechón
DOI:10.2174/1389200211314090002

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Mechanism-based Inhibition of CYP450: An Indicator of Drug-induced Hepatotoxicity open Access plus

Volume: 14   Issue: 9
Pp: 921-945
Shan Feng and Xin He
DOI:10.2174/138920021131400114

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Neonatal Fc Receptor and its Role in the Absorption, Distribution, Metabolism and Excretion of Immunoglobulin G-Based Biotherapeutics open Access plus

Volume: 14   Issue: 7
Pp: 764-790
Craig Giragossian, Tracey Clark, Nicole Piché-Nicholas and Christopher J. Bowman
DOI:10.2174/13892002113149990099

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Nanoparticle- and Liposome-carried Drugs: New Strategies for Active Targeting and Drug Delivery Across Blood-brain Barrier open Access plus

Volume: 14   Issue: 6
Pp: 625-640
Martha Leonor Pinzon-Daza, Ivana Campia, Joanna Kopecka, Ruth Garzon, Dario Ghigo and Chiara Rigant
DOI:10.2174/1389200211314060001

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Insight into Tissue Unbound Concentration: Utility in Drug Discovery and Development open Access plus

Volume: 14   Issue: 3
Pp: 324-340
T. Thanga Mariappan, Sandhya Mandlekar and Punit Marathe
DOI:10.2174/1389200211314030008

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Drug Metabolizing Enzymes in the Perinatal and Neonatal Period: Differences in the Expression and Activity open Access plus

Volume: 14   Issue: 2
Pp: 167-173
Laura Cuzzolin
DOI:10.2174/1389200211314020003

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Yeast as a Humanized Model Organism for Biotransformation-Related Toxicity open Access plus

Volume: 13   Issue: 10
Pp: 1464-1475
Jolanda S. van Leeuwen, Nico P.E. Vermeulen and J. Chris Vos
DOI:10.2174/138920012803762783

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Peroxisomes, Peroxisomal Diseases, and the Hepatotoxicity Induced by Peroxisomal Metabolites open Access plus

Volume: 13   Issue: 10
Pp: 1401-1411
Ronald J.A. Wanders and Sacha Ferdinandusse
DOI:10.2174/138920012803762747

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Isotopic Labeling of Metabolites in Drug Discovery Applications open Access plus

Volume: 13   Issue: 9
Pp: 1213-1225
Jacobo Iglesias, Lekha Sleno and Dietrich A. Volmer
DOI:10.2174/138920012803341357

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Drug-induced Liver Steatosis and Phospholipidosis: Cell-Based Assays for Early Screening of Drug Candidates open Access plus

Volume: 13   Issue: 8
Pp: 1160-1173
M. Teresa Donato and M. Jose Gomez-Lechon
DOI:10.2174/138920012802850001

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Comparison of Cytochrome P450 2C Subfamily Members in Terms of Drug Oxidation Rates and Substrate Inhibition open Access plus

Volume: 13   Issue: 8
Pp: 1145-1159
Toshiro Niwa and Hiroshi Yamazaki
DOI:10.2174/138920012802850092

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Toxicological Profile of Therapeutic Nanodelivery Systems open Access plus

Volume: 13   Issue: 8
Pp: 1068-1086
Luis M. Bimbo, Leena Peltonen, Jouni Hirvonen and Helder A. Santos
DOI:10.2174/138920012802850047

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Animal Models for Evaluation of Drug-Drug Interaction Potential of Biotherapeutics open Access plus

Volume: 13   Issue: 7
Pp: 947-950
Eugenia Kraynov, Martin E. Dowty, Odette Odette A. Fahmi and Owen Fields
DOI:10.2174/138920012802138705

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Effects of Interleukin 1β (IL-1β) and IL-1β/Interleukin 6 (IL-6) Combinations on Drug Metabolizing Enzymes in Human Hepatocyte Culture open Access plus

Volume: 13   Issue: 7
Pp: 930-937
Leslie J. Dickmann, Sonal K. Patel, Larry C. Wienkers and J. Greg Slatter
DOI:10.2174/138920012802138642

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Active Metabolites Resulting from Decarboxylation, Reduction and Ester Hydrolysis of Parent Drugs open Access plus

Volume: 13   Issue: 6
Pp: 835-862
I. Hartyanszky, H. Kalasz, E. Adeghate, Zs. Gulyas, M. Y. Hasan, K. Tekes, A. Adem and P. Sotonyi
DOI:10.2174/138920012800840437

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Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics during Pregnancy: Achievements and Shortcomings open Access plus

Volume: 13   Issue: 6
Pp: 695-720
G. Lu, K. Abduljalil, M. Jamei, T. N. Johnson, H. Soltani and A. Rostami-Hodjegan
DOI:10.2174/138920012800840374

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Herb-Drug Interactions and Mechanistic and Clinical Considerations open Access plus

Volume: 13   Issue: 5
Pp: 640-651
Xiao-Wu Chen, Kevin B. Sneed, Si-Yuan Pan, Chuanhai Cao, Jagat R. Kanwar, Helen Chew and Shu- Feng Zhou
DOI:10.2174/1389200211209050640

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The Role of ABC and SLC Transporters in the Pharmacokinetics of Dietary and Herbal Phytochemicals and their Interactions with Xenobiotics open Access plus

Volume: 13   Issue: 5
Pp: 624-639
Yan Li, Jun Lu and James W. Paxton
DOI:10.2174/1389200211209050624

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Pharmacokinetics and Disposition of Various Drug Loaded Liposomes open Access plus

Volume: 13   Issue: 4
Pp: 372-395
Shuai Qian, Chenrui Li and Zhong Zuo
DOI:10.2174/138920012800166562

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Inherited Copper Transport Disorders: Biochemical Mechanisms, Diagnosis, and Treatment open Access plus

Volume: 13   Issue: 3
Pp: 237-250
Hiroko Kodama, Chie Fujisawa and Wattanaporn Bhadhprasit
DOI:10.2174/138920012799320455

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Is There a Relationship Between the Substrate Preferences and Structural Flexibility of Cytochromes P450? open Access plus

Volume: 13   Issue: 2
Pp: 130-142
Michal Otyepka, Karel Berka and Pavel Anzenbacher
DOI:10.2174/138920012798918372

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Impact of Genetic Polymorphisms and Drug – Drug Interactions on Clopidogrel and Prasugrel Response Variability open Access plus

Volume: 11   Issue: 8
Pp: 667-677
V. Ancrenaz, Y. Daali, P. Fontana, M. Besson, C. Samer, P. Dayer and J. Desmeules
DOI:10.2174/138920010794233521

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Systematic Evaluation of Dose Proportionality Studies in Clinical Pharmacokinetics open Access plus

Volume: 11   Issue: 6
Pp: 526-537
Yucheng Sheng, Yingchun He, Xiaohui Huang, Juan Yang, Kun Wang and Qingshan Zheng
DOI:10.2174/138920010791636185

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Atypical Antipsychotic Metabolism and Excretion open Access plus

Volume: 11   Issue: 6
Pp: 516-525
J.J. Sheehan, J.K. Sliwa, J.C. Amatniek, A. Grinspan and C.M. Canuso
DOI:10.2174/138920010791636202

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Bioavailability of Flavonoids: A Review of Their Membrane Transport and the Function of Bilitranslocase in Animal and Plant Organisms open Access plus

Volume: 10   Issue: 4
Pp: 369-394
Sabina Passamonti, Michela Terdoslavich, Raffaella Franca, Andreja Vanzo, Federica Tramer, Enrico Braidot, Elisa Petrussa and Angelo Vianello
DOI:10.2174/138920009788498950

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Biological Actions and Metabolism of Currently Used Pharmacological Agents for the Treatment of Congestive Heart Failure open Access plus

Volume: 10   Issue: 3
Pp: 206-219
Harjot K. Saini-Chohan and Grant M. Hatch
DOI:10.2174/138920009787846314

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Arylamine N-Acetyltransferases in Mycobacteria open Access plus

Volume: 9   Issue: 6
Pp: 510-519
Edith Sim, James Sandy, Dimitrios Evangelopoulos, Elizabeth Fullam, Sanjib Bhakta, Isaac Westwood, Anna Krylova, Nathan Lack and Martin Noble
DOI:10.2174/138920008784892100

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Lack of Interaction of the NMDA Receptor Antagonists Dextromethorphan and Dextrorphan with P-Glycoprotein open Access plus

Volume: 9   Issue: 2
Pp: 144-151
Jules Desmeules, M. Kanaan, Y. Daali and P. Dayer
DOI:10.2174/138920008783571765

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Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues open Access plus

Volume: 9   Issue: 2
Pp: 129-143
Petr Pavek and Zdenek Dvorak
DOI:10.2174/138920008783571774

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