Current Drug Metabolism

Editor-in-Chief:

Michael Sinz

Bristol Myers Squibb

Princeton, NJ

USA

 

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A Change in Bile Flow: Looking Beyond Transporter Inhibition in the Development of Drug-induced Cholestasis

Volume: 20   Issue: 8
Pp: 621-632
Brandy Garzel, Lei Zhang, Shiew-Mei Huang and Hongbing Wang*
DOI: 10.2174/1389200220666190709170256

Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients open access plus

Volume: 20   Issue: 7
Pp: 592-600
Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*
DOI: 10.2174/1389200220666190701094756

Interethnic Variations of UGT1A1 and UGT1A7 Polymorphisms in the Jordanian Population

Volume: 20   Issue: 5
Pp: 399-410
Sara Abudahab*, Nancy Hakooz, Yazun Jarrar, Mohammad Al Shahhab, Ahmad Saleh, Malek Zihlif and Rana Dajani
DOI: 10.2174/1389200220666190528085151

Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis open access plus

Volume: 20   Issue: 4
Pp: 266-274
Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*
DOI: 10.2174/1389200220666190111114146

Survey of Machine Learning Techniques for Prediction of the Isoform Specificity of Cytochrome P450 Substrates

Volume: 20   Issue: 3
Pp: 229-235
Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu* and Dong-Qing Wei*
DOI: 10.2174/1389200219666181019094526

The Impact of Carboxylesterases in Drug Metabolism and Pharmacokinetics open access plus

Volume: 20   Issue: 2
Pp: 91-102
Li Di*
DOI: 10.2174/1389200219666180821094502

Sodium Oxybate Therapy for Alcohol Withdrawal Syndrome and Keeping of Alcohol Abstinence

Volume: 19   Issue: 13
Pp: 1056-1064
Carmen Mannucci, Simona Pichini, Elvira Ventura Spagnolo, Fabrizio Calapai, Sebastiano Gangemi, Michele Navarra and Gioacchino Calapai*
DOI: 10.2174/1389200219666171207122227

Drug-induced Cholestasis: Mechanisms, Models, and Markers

Volume: 19   Issue: 10
Pp: 808-818
Sagnik Chatterjee* and Pieter Annaert
DOI: 10.2174/1389200219666180427165035

Formulations, Pharmacodynamic and Clinical Studies of Nanoparticles for Lung Cancer Therapy - An Overview

Volume: 19   Issue: 9
Pp: 759-767
Dandan Zheng, Jinglong Wang, Shengrong Guo, Zhongxi Zhao* and Feihu Wang*
DOI: 10.2174/1389200219666180305145345

Regulation of Mammalian UDP-Glucuronosyltransferases

Volume: 19   Issue: 6
Pp: 490-501
Hong Wang, Guoxiu Cao, Guangji Wang* and Haiping Hao*
DOI: 10.2174/1389200219666180307122945

Herb-Drug Interactions in Neurological Disorders: A Critical Appraisal

Volume: 19   Issue: 5
Pp: 443-453
Vinu Wilson and Subir Kumar Maulik*
DOI: 10.2174/1389200218666171031123738

Inter-individual Variability in Activity of the Major Drug Metabolizing Enzymes in Liver Homogenates of 20 Individuals

Volume: 19   Issue: 4
Pp: 370-381
Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Marc van Dijk, Yongjie Zhang, Stefan J. Dekker, Lukas Wijaya, Nico P.E. Vermeulen, Lysiane Richert, Jan N.M. Commandeur and J. Chris Vos*
DOI: 10.2174/1389200219666180108160046

Medicinal and Therapeutic Potential of Herbs and Plant Metabolites / Extracts Countering Viral Pathogens - Current Knowledge and Future Prospects

Volume: 19   Issue: 3
Pp: 236-263
Kuldeep Dhama*, Kumaragurubaran Karthik, Rekha Khandia, Ashok Munjal, Ruchi Tiwari, Rajneesh Rana, Sandip Kumar Khurana, Sana Ullah, Rifat Ullah Khan, Mahmoud Alagawany, Mayada Ragab Farag, Maryam Dadar and Sunil Kumar Joshi
DOI: 10.2174/1389200219666180129145252

Development and Uses of Offline and Web-Searchable Metabolism Databases - The Case of Benzo[a]pyrene promotion: free to download

Volume: 19   Issue: 1
Pp: 3-46
Slobodan P. Rendic* and Frederick P. Guengerich
DOI: 10.2174/1389200219666171207123939

Differential Regulation of CYP3A4 and CYP3A5 and its Implication in Drug Discovery

Volume: 18   Issue: 12
Pp: 1095-1105
Ogheneochukome Lolodi, Yue-Ming Wang, William C. Wright and Taosheng Chen*
DOI: 10.2174/1389200218666170531112038

Virus-Host Interactions: New Insights and Advances in Drug Development Against Viral Pathogens

Volume: 18   Issue: 10
Pp: 942-970
Minakshi Prasad *, Koushlesh Ranjan , Basanti Brar , Ikbal Shah, Upendra Lalmbe , J. Manimegalai , Bhavya Vashisht, Madhusudan Gaury , Pawan Kumar , Sandip Kumar Khurana , Gaya Prasad , Jagveer Rawat , Vikas Yadav , Sunil Kumar and Rekha Rao
DOI: 10.2174/1389200218666170925115132

Strategies of Engineering Nanoparticles for Treating Neurodegenerative Disorders

Volume: 18   Issue: 9
Pp: 786-797
Khanh Tu Nguyen, Minh Nguyet Pham, Toi Van Vo, Wei Duan, Phuong Ha-Lien Tran* and Thao Truong-Dinh Tran*
DOI: 10.2174/1389200218666170125114751

A Review on Pharmacokinetics of Levetiracetam in Neonates

Volume: 18   Issue: 8
Pp: 727-734
Amit Agrawal* and Anita Banergee
DOI: 10.2174/1389200218666170607100054

Apixaban - Metabolism, Pharmacologic Properties and Drug Interactions

Volume: 18   Issue: 7
Pp: 609-621
Peter Kubisz, Lucia Stanciakova*, Miroslava Dobrotova, Matej Samos, Marian Mokan and Jan Stasko
DOI: 10.2174/1389200218666170424151551

Drug Metabolism in Preclinical Drug Development: A Survey of the Discovery Process, Toxicology, and Computational Tools

Volume: 18   Issue: 6
Pp: 556-565
Naiem T. Issa, Henri Wathieu, Abiola Ojo, Stephen W. Byers and Sivanesan Dakshanamurthy*
DOI: 10.2174/1389200218666170316093301

Transdermal Drug Delivery: Opportunities and Challenges for Controlled Delivery of Therapeutic Agents Using Nanocarriers

Volume: 18   Issue: 5
Pp: 481-495
Balak Das Kurmi, Pawan Tekchandani, Rishi Paliwal and Shivani Rai Paliwal*
DOI: 10.2174/1389200218666170222150555

Status Epilepticus: An Overview

Volume: 18   Issue: 3
Pp: 174-185
Venkata Ramesh Yasam, Venkatachalam Senthil, Satya Lavanya Jakki and Natarajan Jawahar
DOI: 10.2174/1389200218666170106091705

Nanoparticles as a Carrier System for Drug Delivery Across Blood Brain Barrier

Volume: 18   Issue: 2
Pp: 129-137
Alika Sarkar, Ismat Fatima, Qazi Mohammad Sajid Jamal, Usman Sayeed, Mohammad Kalim A. Khan, Salman Akhtar, Mohammad Amjad Kamal, Alvina Farooqui and Mohammad Haris Siddiqui
DOI: 10.2174/1389200218666170113125132

Bacteria From Marine Sponges: A Source of New Drugs

Volume: 18   Issue: 1
Pp: 11-15
Fehmida Bibi, Muhammad Faheem, Esam I. Azhar, Muhammad Yasir, Sana A. Alvi, Mohammad A. Kamal, Ikram Ullah and Muhammad I. Naseer
DOI: 10.2174/1389200217666161013090610

The Role of Drug Transporters in the Pharmacokinetics of Antibiotics

Volume: 17   Issue: 8
Pp: 799-805
Wen Jin Hua, Wei Xiao Hua, Zhou Jian, Peng Hong Wei, Lu Yan Ni, Li Yu Hua, Cao Duan Wen, Zhou Ying and Cao Li
DOI: 10.2174/1389200217666160629114449

A Comparison of Non-Human Primate Cytochrome P450 2D Members and the Implication in Drug Discovery

Volume: 17   Issue: 6
Pp: 520-527
Zhi-Xu He, Xiao-Wu Chen, Yinxue Yang and Shu-Feng Zhou
DOI: 10.2174/1389200217666160219114241

Drug Transporters and Multiple Drug Resistance in the Most Common Pediatric Solid Tumors

Volume: 17   Issue: 4
Pp: 308-316
Doriana Fruci, William C.S. Cho, Paolo Romania, Valerio Nobili, Franco Locatelli and Anna Alisi
DOI: 10.2174/1567205010666131212110948

Cannabinoids and Cytochrome P450 Interactions

Volume: 17   Issue: 3
Pp: 206-226
Ondřej Zendulka, Gabriela Dovrtělová, Kristýna Nosková, Miroslav Turjap, Alexandra Šulcová, Lumír Hanuš and Jan Juřica
DOI: 10.2174/1389200217666151210142051

UGT1A1 Mediated Drug Interactions and its Clinical Relevance

Volume: 17   Issue: 2
Pp: 100-106
Chong Ping Goon, Ling Zhi Wang, Fang Cheng Wong, Win Lwin Thuya, Paul Chi-Lui Ho and Boon Cher Goh
DOI: 10.2174/1389200216666151103121253

Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines open access plus

Volume: 16   Issue: 6
Pp: 412-426
Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti
DOI: 10.2174/1389200216888150915112039

Nucleic Acids Delivery Systems: A Challenge for Pharmaceutical Technologists promotion: free to download

Volume: 16   Issue: 1
Pp: 3-16
Ana C. Silva, Carla M. Lopes, Jose M. Sousa Lobo and M. Helena Amaral
DOI: 10.2174/1389200216666150401110211

Liposomes as siRNA Delivery Vectors

Volume: 15   Issue: 9
Pp: 882-892
Sabrina Bochicchio, Annalisa Dalmoro, Anna Angela Barba, Gabriele Grassi and Gaetano Lamberti
DOI: 10.2174/1389200216666150206124913

Quantitative Evaluation of Drug-Drug Interaction Potentials by in vivo Information- Guided Prediction Approach

Volume: 15   Issue: 8
Pp: 761-766
Feng Chen, Zhe-Yi Hu, Wei-Wei Jia, Jing-Tao Lu and Yuan-Sheng Zhao
DOI: 10.2174/1389200216666150223151758

Protein Engineering: A New Frontier for Biological Therapeutics

Volume: 15   Issue: 7
Pp: 743-756
Peter H. Tobin, David H. Richards, Randolph A. Callender and Corey J. Wilson
DOI: 10.2174/1389200216666141208151524

Galvez-Markov Network Transferability Indices: Review of Classic Theory and New Model for Perturbations in Metabolic Reactions

Volume: 15   Issue: 5
Pp: 557-564
Jorge Vergara-Galicia, Francisco J. Prado-Prado and Humberto Gonzalez-Diaz
DOI: 10.2174/1389200215666140605125827

Matrix Trace Operators: From Spectral Moments of Molecular Graphs and Complex Networks to Perturbations in Synthetic Reactions, Micelle Nanoparticles, and Drug ADME Processes

Volume: 15   Issue: 4
Pp: 470-488
Humberto Gonzalez-Diaz, Sonia Arrasate, Asier Gomez-San Juan, Nuria Sotomayor, Esther Lete, Alejandro Speck-Planche, Juan M. Ruso, Feng Luan and Maria Natalia Dias Soeiro Cordeiro
DOI: 10.2174/1389200215666140908101604